Dissemination of New Methicillin-Resistant Staphylococcus aureus Clones in the Community

ABSTRACT Multiple methicillin-resistant Staphylococcus aureus (MRSA) clones carrying type IV staphylococcal cassette chromosome mec were identified in the community-acquired MRSA strains of both the United States and Australia. They multiplied much faster than health-care-associated MRSA and were resistant to fewer non-beta-lactam antibiotics. They seem to have been derived from more diverse S. aureus populations than health-care-associated MRSA strains.

[1]  B. Jalaludin,et al.  Non‐multiresistant and multiresistant methicillin‐resistant Staphylococcus aureus in community‐acquired infections , 2001, The Medical journal of Australia.

[2]  Robert S. Daum,et al.  Novel Type of Staphylococcal Cassette Chromosome mec Identified in Community-Acquired Methicillin-Resistant Staphylococcus aureus Strains , 2002, Antimicrobial Agents and Chemotherapy.

[3]  M. Kuroda,et al.  The emergence and evolution of methicillin-resistant Staphylococcus aureus. , 2001, Trends in microbiology.

[4]  P. Gerhardt,et al.  Methods for general and molecular bacteriology , 1994 .

[5]  K. Chant,et al.  COMMUNITY‐ACQUIRED, NON‐MULTIRESISTANT OXACILLIN‐RESISTANT STAPHYLOCOCCUS AUREUS (NORSA) IN SOUTH WESTERN SYDNEY , 2001, Pathology.

[6]  T. Riley,et al.  Community Strain of Methicillin-Resistant Staphylococcus aureus Involved in a Hospital Outbreak , 1999, Journal of Clinical Microbiology.

[7]  B. Cookson,et al.  Dominance of EMRSA-15 and -16 among MRSA causing nosocomial bacteraemia in the UK: analysis of isolates from the European Antimicrobial Resistance Surveillance System (EARSS). , 2001, The Journal of antimicrobial chemotherapy.

[8]  K. Hiramatsu,et al.  Analysis of Borderline‐Resistant Strains of Methicillin‐Resistant Staphylococcus aureus Using Polymerase Chain Reaction , 1992, Microbiology and immunology.

[9]  A. Alghaithy,et al.  Nasal carriage and antibiotic resistance of Staphylococcus aureus isolates from hospital and non-hospital personnel in Abha, Saudi Arabia. , 2000, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[10]  Y. Fukuchi,et al.  Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin , 1997, The Lancet.

[11]  W. Schaffner,et al.  An outbreak of community-acquired foodborne illness caused by methicillin-resistant Staphylococcus aureus. , 2002, Emerging infectious diseases.

[12]  K. Hiramatsu,et al.  New trends in Staphylococcus aureus infections: glycopeptide resistance in hospital and methicillin resistance in the community , 2002, Current opinion in infectious diseases.

[13]  CDC definitions for nosocomial infections, 1988. , 1989, The American review of respiratory disease.

[14]  Teruyo Ito,et al.  A New Class of Genetic Element, Staphylococcus Cassette Chromosome mec, Encodes Methicillin Resistance in Staphylococcus aureus , 2000, Antimicrobial Agents and Chemotherapy.

[15]  Teruyo Ito,et al.  Genetic Organization of the Chromosome Region Surrounding mecA in Clinical Staphylococcal Strains: Role of IS431-Mediated mecI Deletion in Expression of Resistance in mecA-Carrying, Low-Level Methicillin- Resistant Staphylococcus haemolyticus , 2001, Antimicrobial Agents and Chemotherapy.

[16]  J M Hughes,et al.  CDC definitions for nosocomial infections, 1988. , 1988, American journal of infection control.

[17]  H. Chambers,et al.  The changing epidemiology of Staphylococcus aureus? , 2001, Emerging infectious diseases.

[18]  Teruyo Ito,et al.  Structural Comparison of Three Types of Staphylococcal Cassette Chromosome mec Integrated in the Chromosome in Methicillin-Resistant Staphylococcus aureus , 2001, Antimicrobial Agents and Chemotherapy.

[19]  D. Lauderdale,et al.  Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk. , 1998, JAMA.

[20]  K. Hiramatsu Molecular Evolution of MRSA , 1995, Microbiology and immunology.

[21]  J. Bell,et al.  Methicillin-resistant Staphylococcal aureus evolution in Australia over 35 years. , 2000, Microbial drug resistance.

[22]  Amy V. Groom,et al.  Epidemiology and clonality of community-acquired methicillin-resistant Staphylococcus aureus in Minnesota, 1996-1998. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[23]  H. Kuroda-Murakami [Mechanisms of methicillin and vancomycin resistance in Staphylococcus aureus]. , 2001, Nihon rinsho. Japanese journal of clinical medicine.

[24]  C. Walsh,et al.  The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA) , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[25]  D H Persing,et al.  Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing , 1995, Journal of clinical microbiology.

[26]  Y. Nagai,et al.  Genome and virulence determinants of high virulence community-acquired MRSA , 2002, The Lancet.

[27]  G. Nimmo,et al.  Community Acquisition of Gentamicin-Sensitive Methicillin-Resistant Staphylococcus aureus in Southeast Queensland, Australia , 2000, Journal of Clinical Microbiology.