Leuprolide Acetate, a GnRH Agonist, Improves Experimental Autoimmune Encephalomyelitis: A Possible Therapy for Multiple Sclerosis

[1]  M. Kamasak,et al.  Protein biomarkers for multiple sclerosis: semi-quantitative analysis of cerebrospinal fluid candidate protein biomarkers in different forms of multiple sclerosis , 2012, Multiple sclerosis.

[2]  D. Centonze,et al.  Interleukin‐1β causes synaptic hyperexcitability in multiple sclerosis , 2012, Annals of neurology.

[3]  B. Xiao,et al.  Targeting CB(2) receptor as a neuroinflammatory modulator in experimental autoimmune encephalomyelitis. , 2011, Molecular immunology.

[4]  B. Castellano,et al.  Increase in Th17 and T-reg Lymphocytes and Decrease of IL22 Correlate with the Recovery Phase of Acute EAE IN Rat , 2011, PloS one.

[5]  F. Tchantchou,et al.  Arachidonyl trifluoromethyl ketone ameliorates experimental autoimmune encephalomyelitis via blocking peroxynitrite formation in mouse spinal cord white matter , 2011, Experimental Neurology.

[6]  Xiongwei Zhu,et al.  Neurofilamentopathy in Neurodegenerative Diseases , 2011, The open neurology journal.

[7]  A. Toulouse,et al.  Neurotrophic factors for the treatment of Parkinson's disease. , 2011, Cytokine & growth factor reviews.

[8]  J. Quintanar,et al.  Gonadotropin-releasing hormone reduces the severity of experimental autoimmune encephalomyelitis, a model of multiple sclerosis , 2011, Neuropeptides.

[9]  H. Butzkueven,et al.  Neurofilament Proteins as Body Fluid Biomarkers of Neurodegeneration in Multiple Sclerosis , 2011, Multiple sclerosis international.

[10]  J. Chuckowree,et al.  Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system , 2009, Brain Research Bulletin.

[11]  J. Quintanar,et al.  Gonadotropin-releasing hormone receptor in spinal cord neurons of embryos and adult rats , 2009, Neuroscience Letters.

[12]  R. Arnon,et al.  Neuroprotection and neurogeneration in MS and its animal model EAE effected by glatiramer acetate , 2009, Journal of Neural Transmission.

[13]  S. Sadiq,et al.  Disease biomarkers in multiple sclerosis: potential for use in therapeutic decision making. , 2009, Molecular diagnosis & therapy.

[14]  J. Goverman.  Autoimmune T cell responses in the central nervous system , 2009, Nature Reviews Immunology.

[15]  Manuel A. Friese,et al.  From genes to function: the next challenge to understanding multiple sclerosis , 2009, Nature Reviews Immunology.

[16]  D. Mirowska-Guzel.  The role of neurotrophic factors in the pathology and treatment of multiple sclerosis , 2009, Immunopharmacology and immunotoxicology.

[17]  Quentin Liu,et al.  Overexpression of CNTF in Mesenchymal Stem Cells reduces demyelination and induces clinical recovery in experimental autoimmune encephalomyelitis mice , 2009, Journal of Neuroimmunology.

[18]  R. Berges,et al.  Review of the Multiple Aspects of Neurofilament Functions, and their Possible Contribution to Neurodegeneration , 2008, Molecular Neurobiology.

[19]  C. Bever,et al.  Brain derived neurotrophic factor treatment reduces inflammation and apoptosis in experimental allergic encephalomyelitis , 2008, Journal of the Neurological Sciences.

[20]  E. Crawford,et al.  Leuprorelin depot injection: patient considerations in the management of prostatic cancer , 2008, Therapeutics and clinical risk management.

[21]  D. Nathan,et al.  Adipocytokines, obesity, and insulin resistance during combined androgen blockade for prostate cancer. , 2008, Urology.

[22]  Michael Schoen,et al.  Gonadotropin-releasing hormone regulates spine density via its regulatory role in hippocampal estrogen synthesis , 2008, The Journal of cell biology.

[23]  A. Baxter,et al.  The origin and application of experimental autoimmune encephalomyelitis , 2007, Nature Reviews Immunology.

[24]  C. Atwood,et al.  Leuprolide acetate: a drug of diverse clinical applications , 2007, Expert opinion on investigational drugs.

[25]  C. Atwood,et al.  The role of hypothalamic-pituitary-gonadal hormones in the normal structure and functioning of the brain. , 2005, Cellular and molecular life sciences : CMLS.

[26]  V. Perry,et al.  Cytokine‐induced enhancement of autoimmune inflammation in the brain and spinal cord: implications for multiple sclerosis , 2004, Neuropathology and applied neurobiology.

[27]  A. Bar-Or,et al.  Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions , 2003, Journal of Neuroimmunology.

[28]  I. Goshen,et al.  Experimental autoimmune encephalomyelitis-associated behavioral syndrome as a model of ‘depression due to multiple sclerosis’ , 2002, Brain, Behavior, and Immunity.

[29]  P. Wise.  Estrogens and neuroprotection , 2002, Trends in Endocrinology & Metabolism.

[30]  B. Becher,et al.  The Clinical Course of Experimental Autoimmune Encephalomyelitis and Inflammation Is Controlled by the Expression of Cd40 within the Central Nervous System , 2001, The Journal of experimental medicine.

[31]  M. Schwartz,et al.  Production of neurotrophins by activated T cells: implications for neuroprotective autoimmunity. , 2000, Journal of autoimmunity.

[32]  Y. Barde.  Help from within for damaged axons , 1997, Nature.

[33]  H. Thoenen.  Neurotrophins and Neuronal Plasticity , 1995, Science.

[34]  W. Banks,et al.  Bidirectional saturable transport of LHRH across the blood-brain barrier. , 1991, The American journal of physiology.

[35]  P. Carnegie,et al.  Concomitant detection of changes in myelin basic protein and permeability of blood-spinal cord barrier in acute experimental autoimmune encephalomyelitis by electroimmunoblotting , 1985, Journal of Neuroimmunology.

[36]  A. Kastin,et al.  Dissociation of effects of LH-RH analogs on pituitary regulation and reproductive behavior , 1980, Pharmacology Biochemistry and Behavior.

[37]  M. Fujino,et al.  Synthetic analogs of luteinizing hormone releasing hormone (LH-RH) substituted in position 6 and 10. , 1974, Biochemical and biophysical research communications.

[38]  J. Quintanar,et al.  Neurotrophic Effects of GnRH on Neurite Outgrowth and Neurofilament Protein Expression in Cultured Cerebral Cortical Neurons of Rat Embryos , 2007, Neurochemical Research.

[39]  K. Kovacs,et al.  Neurointermediate pituitary lobectomy decreases the incidence and severity of experimental autoimmune encephalomyelitis in Lewis rats. , 2005, The Journal of endocrinology.

[40]  J. Mussini,et al.  [Immunology of multiple sclerosis]. , 1982, La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris.