HnRNP K reduces viral gene expression by targeting cytosine-rich sequences in porcine reproductive and respiratory syndrome virus-2 genome to dampen the viral growth.

[1]  Jinhao Li,et al.  Epidemiological investigation and genetic evolutionary analysis of PRRSV-1 on a pig farm in China , 2022, Frontiers in Microbiology.

[2]  S. Xiao,et al.  Porcine Reproductive and Respiratory Syndrome Virus nsp1β Stabilizes HIF-1α to Enhance Viral Replication , 2022, Microbiology spectrum.

[3]  Cuiqin Huang,et al.  Molecular Characteristics and Pathogenicity of a Novel Recombinant Porcine Reproductive and Respiratory Syndrome Virus Strain from NADC30-, NADC34-, and JXA1-Like Strains That Emerged in China , 2022, Microbiology spectrum.

[4]  Wu Tong,et al.  hnRNP K Degrades Viral Nucleocapsid Protein and Induces Type I IFN Production to Inhibit Porcine Epidemic Diarrhea Virus Replication , 2022, Journal of virology.

[5]  H. Nauwynck,et al.  A New Long Noncoding RNA, MAHAT, Inhibits Replication of Porcine Reproductive and Respiratory Syndrome Virus by Recruiting DDX6 To Bind to ZNF34 and Promote an Innate Immune Response , 2022, Journal of virology.

[6]  Yongning Zhang,et al.  Viral evasion of PKR restriction by reprogramming cellular stress granules , 2022, Proceedings of the National Academy of Sciences of the United States of America.

[7]  Jue Liu,et al.  Seneca Valley Virus 3Cpro Cleaves Heterogeneous Nuclear Ribonucleoprotein K to Facilitate Viral Replication , 2022, Frontiers in Microbiology.

[8]  G. Zhu,et al.  Identification of MYH9 Key Domain Involved in the Entry of PRRSV Into Permissive Cells , 2022, Frontiers in Microbiology.

[9]  Yan Zhang,et al.  Interaction of HnRNP F with the guanine-rich segments in viral antigenomic RNA enhances porcine reproductive and respiratory syndrome virus-2 replication , 2022, Virology journal.

[10]  Feng Wen,et al.  A novel amino acid site of N protein could affect the PRRSV-2 replication by regulating the viral RNA transcription , 2022, BMC Veterinary Research.

[11]  W. Yuan,et al.  cGAS Restricts PRRSV Replication by Sensing the mtDNA to Increase the cGAMP Activity , 2022, Frontiers in Immunology.

[12]  Jing Yang,et al.  Recombination between NADC34-like and QYYZ-like strain of Porcine Reproductive and Respiratory Syndrome virus with high pathogenicity for piglets in China. , 2022, Transboundary and emerging diseases.

[13]  Rui Li,et al.  Tumor Susceptibility Gene 101 (TSG101) Contributes to Virion Formation of Porcine Reproductive and Respiratory Syndrome Virus via Interaction with the Nucleocapsid (N) Protein along with the Early Secretory Pathway , 2022, Journal of virology.

[14]  Jian-Piao Cai,et al.  hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs , 2022, Emerging microbes & infections.

[15]  Lilin Zhang,et al.  The C/EBPβ-Dependent Induction of TFDP2 Facilitates Porcine Reproductive and Respiratory Syndrome Virus Proliferation , 2021, Virologica Sinica.

[16]  A. Firth,et al.  A swine arterivirus deubiquitinase stabilizes two major envelope proteins and promotes production of viral progeny , 2021, PLoS pathogens.

[17]  M. Murtaugh,et al.  Isolation of Porcine Reproductive and Respiratory Syndrome Virus GP5-Specific, Neutralizing Monoclonal Antibodies From Hyperimmune Sows , 2021, Frontiers in Immunology.

[18]  I. Brierley,et al.  Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression , 2019, bioRxiv.

[19]  Lilin Zhang,et al.  RBM39 Alters Phosphorylation of c-Jun and Binds to Viral RNA to Promote PRRSV Proliferation , 2020, bioRxiv.

[20]  Trushar R. Patel,et al.  Molecular characterization of the RNA-protein complex directing −2/−1 programmed ribosomal frameshifting during arterivirus replicase expression , 2020, The Journal of Biological Chemistry.

[21]  R. Batey,et al.  hnRNPK recognition of the B motif of Xist and other biological RNAs , 2020, Nucleic acids research.

[22]  P. Fratta,et al.  The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis , 2020, Acta Neuropathologica.

[23]  A. Herbert.  Simple Repeats as Building Blocks for Genetic Computers. , 2020, Trends in genetics : TIG.

[24]  Decheng Yang,et al.  hnRNP K Is a Novel Internal Ribosomal Entry Site-Transacting Factor That Negatively Regulates Foot-and-Mouth Disease Virus Translation and Replication and Is Antagonized by Viral 3C Protease , 2020, Journal of Virology.

[25]  S. Cherry,et al.  Viral-induced alternative splicing of host genes promotes influenza replication , 2020, bioRxiv.

[26]  Hongbin He,et al.  Cell apoptosis regulated by interaction between viral gene alpha 3 and host heterogeneous nuclear ribonucleoprotein K facilitates bovine ephemeral fever virus replication. , 2020, Veterinary microbiology.

[27]  J. Plavec,et al.  A dynamic i-motif with a duplex stem-loop in the long terminal repeat promoter of the HIV-1 proviral genome modulates viral transcription , 2019, Nucleic acids research.

[28]  Wenting Ke,et al.  Nuclear localization signal in TRIM22 is essential for inhibition of type 2 porcine reproductive and respiratory syndrome virus replication in MARC-145 cells , 2019, Virus Genes.

[29]  Jianchao Wei,et al.  Porcine reproductive and respiratory syndrome virus counteracts type I interferon-induced early antiviral state by interfering IRF7 activity. , 2019, Veterinary microbiology.

[30]  H. Gautrey,et al.  Regulation of Mcl-1 alternative splicing by hnRNP F, H1 and K in breast cancer cells , 2018, RNA biology.

[31]  Matthew R. Gazzara,et al.  Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing , 2018, Nature Communications.

[32]  H. Schwalbe,et al.  Interaction of the N‐Terminal Tandem Domains of hnRNP LL with the BCL2 Promoter i‐Motif DNA Sequence , 2017, Chembiochem : a European journal of chemical biology.

[33]  H. Mao,et al.  A Mechanosensor Mechanism Controls the G-Quadruplex/i-Motif Molecular Switch in the MYC Promoter NHE III1. , 2016, Journal of the American Chemical Society.

[34]  Hyun-Jin Kang,et al.  Interaction of Individual Structural Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA. , 2016, Journal of the American Chemical Society.

[35]  S. Napthine,et al.  A novel role for poly(C) binding proteins in programmed ribosomal frameshifting , 2016, Nucleic acids research.

[36]  Z. Li,et al.  Identification of a nucleotide in 5′ untranslated region contributing to virus replication and virulence of Coxsackievirus A16 , 2016, Scientific Reports.

[37]  E. Pedersen,et al.  GC-elements controlling HRAS transcription form i-motif structures unfolded by heterogeneous ribonucleoprotein particle A1 , 2015, Scientific Reports.

[38]  V. Castilla,et al.  The heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a host factor required for dengue virus and Junín virus multiplication. , 2015, Virus research.

[39]  Heng Zhu,et al.  A Human Proteome Microarray Identifies that the Heterogeneous Nuclear Ribonucleoprotein K (hnRNP K) Recognizes the 5′ Terminal Sequence of the Hepatitis C Virus RNA* , 2013, Molecular & Cellular Proteomics.

[40]  L. Arike,et al.  Magnetic Fractionation and Proteomic Dissection of Cellular Organelles Occupied by the Late Replication Complexes of Semliki Forest Virus , 2013, Journal of Virology.

[41]  A. Pattnaik,et al.  Heterogeneous Nuclear Ribonucleoprotein K Supports Vesicular Stomatitis Virus Replication by Regulating Cell Survival and Cellular Gene Expression , 2013, Journal of Virology.

[42]  E. Remmerswaal,et al.  Granzyme M targets host cell hnRNP K that is essential for human cytomegalovirus replication , 2012, Cell Death and Differentiation.

[43]  F. Osorio,et al.  An interactome map of the nucleocapsid protein from a highly pathogenic North American porcine reproductive and respiratory syndrome virus strain generated using SILAC‐based quantitative proteomics , 2012, Proteomics.

[44]  C. Szeto,et al.  Contribution of the first K-homology domain of poly(C)-binding protein 1 to its affinity and specificity for C-rich oligonucleotides , 2012, Nucleic acids research.

[45]  P. Vidalain,et al.  Mapping of Chikungunya Virus Interactions with Host Proteins Identified nsP2 as a Highly Connected Viral Component , 2012, Journal of Virology.

[46]  Wei Zhang,et al.  Cytidine deaminase APOBEC3B interacts with heterogeneous nuclear ribonucleoprotein K and suppresses hepatitis B virus expression , 2007, Cellular microbiology.

[47]  R. Hardy,et al.  Heterogeneous nuclear ribonuclear protein K interacts with Sindbis virus nonstructural proteins and viral subgenomic mRNA. , 2007, Virology.

[48]  E. Ren,et al.  Host Heterogeneous Ribonucleoprotein K (hnRNP K) as a Potential Target to Suppress Hepatitis B Virus Replication , 2005, PLoS Medicine.

[49]  J. Ostrowski,et al.  Characterization of hnRNP K protein-RNA interactions. , 2004, Journal of molecular biology.

[50]  G. Zachos,et al.  CK2 Protein Kinase Is Stimulated and Redistributed by Functional Herpes Simplex Virus ICP27 Protein , 2003, Journal of Virology.

[51]  M. Hentze,et al.  c-Src-Mediated Phosphorylation of hnRNP K Drives Translational Activation of Specifically Silenced mRNAs , 2002, Molecular and Cellular Biology.

[52]  S. H. Wang,et al.  The heterogeneous nuclear ribonucleoprotein K (hnRNP K) interacts with dengue virus core protein. , 2001, DNA and cell biology.

[53]  D. L. Lyakhov,et al.  Optimized RNA Targets of Two Closely Related Triple KH Domain Proteins, Heterogeneous Nuclear Ribonucleoprotein K and αCP-2KL, Suggest Distinct Modes of RNA Recognition* , 2001, The Journal of Biological Chemistry.

[54]  R. Everett,et al.  The Multifunctional Herpes Simplex Virus IE63 Protein Interacts with Heterogeneous Ribonucleoprotein K and with Casein Kinase 2* , 1999, The Journal of Biological Chemistry.

[55]  M. Lai,et al.  Hepatitis C Virus Core Protein Interacts with Heterogeneous Nuclear Ribonucleoprotein K* , 1998, The Journal of Biological Chemistry.