The biosynthesis and genetic engineering of bioactive indole alkaloids in plants
暂无分享,去创建一个
Y. Diao | Lei Zhang | Hexin Tan | Xunxun Wu | Yuxiang Huang | Zhiying Guo | Qinglei Zhang
[1] C. Peebles,et al. Engineering overexpression of ORCA3 and strictosidine glucosidase in Catharanthus roseus hairy roots increases alkaloid production , 2016, Protoplasma.
[2] H. Koh,et al. The anti-hypertensive drug reserpine induces neuronal cell death through inhibition of autophagic flux. , 2015, Biochemical and biophysical research communications.
[3] T. Kawasaki,et al. DMSO/Tf2O-mediated cross-coupling of tryptamine with substituted aniline to access C3a-N1'-linked pyrroloindoline alkaloids. , 2015, Organic & biomolecular chemistry.
[4] S. Glatt,et al. Interaction effects between the 5-hydroxy tryptamine transporter-linked polymorphic region (5-HTTLPR) genotype and family conflict on adolescent alcohol use and misuse. , 2015, Addiction.
[5] V. Srivastava,et al. Hairy root biotechnology of Rauwolfia serpentina: a potent approach for the production of pharmaceutically important terpenoid indole alkaloids , 2015, Biotechnology Letters.
[6] P. Tudzynski,et al. Biosynthetic Pathways of Ergot Alkaloids , 2014, Toxins.
[7] Z. Zhang,et al. A novel method for the evaluation of virus-induced gene silencing efficiency. , 2014, Genetics and molecular research : GMR.
[8] Sung-Joon Lee,et al. Multidrug and toxic compound extrusion protein-1 (MATE1/SLC47A1) is a novel flavonoid transporter. , 2014, Journal of agricultural and food chemistry.
[9] Y. Moriyama,et al. Involvement of the Leaf-Specific Multidrug and Toxic Compound Extrusion (MATE) Transporter Nt-JAT2 in Vacuolar Sequestration of Nicotine in Nicotiana tabacum , 2014, PloS one.
[10] W. Kreis,et al. Iridoid synthase activity is common among the plant progesterone 5β-reductase family. , 2014, Molecular plant.
[11] R. Verpoorte,et al. Jasmonic Acid Effect on the Fatty Acid and Terpenoid Indole Alkaloid Accumulation in Cell Suspension Cultures of Catharanthus roseus , 2014, Molecules.
[12] Ling Yuan,et al. Analyses of Catharanthus roseus and Arabidopsis thaliana WRKY transcription factors reveal involvement in jasmonate signaling , 2014, BMC Genomics.
[13] J. Peiris,et al. Anti-inflammatory and antiviral effects of indirubin derivatives in influenza A (H5N1) virus infected primary human peripheral blood-derived macrophages and alveolar epithelial cells. , 2014, Antiviral research.
[14] V. De Luca,et al. Making iridoids/secoiridoids and monoterpenoid indole alkaloids: progress on pathway elucidation. , 2014, Current opinion in plant biology.
[15] H. Bouwmeester,et al. The seco-iridoid pathway from Catharanthus roseus , 2014, Nature Communications.
[16] Dongping Cheng,et al. Anti-Proliferative and Apoptosis-Inducing Effects of Camptothecin-20(s)-O-(2-pyrazolyl-1)acetic Ester in Human Breast Tumor MCF-7 Cells , 2014, Molecules.
[17] Wansheng Chen,et al. Biosynthesis of the active compounds of Isatis indigotica based on transcriptome sequencing and metabolites profiling , 2013, BMC Genomics.
[18] V. De Luca,et al. Virus-induced gene silencing identifies Catharanthus roseus 7-deoxyloganic acid-7-hydroxylase, a step in iridoid and monoterpene indole alkaloid biosynthesis. , 2013, The Plant journal : for cell and molecular biology.
[19] J. Pickett,et al. Responses of Herbivore and Predatory Mites to Tomato Plants Exposed to Jasmonic Acid Seed Treatment , 2013, Journal of Chemical Ecology.
[20] B. Halkier,et al. De novo genetic engineering of the camalexin biosynthetic pathway. , 2013, Journal of biotechnology.
[21] Y. Zu,et al. Enzyme Inhibitor Studies Reveal Complex Control of Methyl-D-Erythritol 4-Phosphate (MEP) Pathway Enzyme Expression in Catharanthus roseus , 2013, PloS one.
[22] Natalia Dudareva,et al. Biosynthesis, function and metabolic engineering of plant volatile organic compounds. , 2013, The New phytologist.
[23] L. Almagro,et al. Synergistic and cytotoxic action of indole alkaloids produced from elicited cell cultures of Catharanthus roseus , 2013, Pharmaceutical biology.
[24] Yuan Li,et al. Reply: Complexity in Camalexin Biosynthesis , 2013, Plant Cell.
[25] B. Halkier,et al. Assigning Gene Function in Biosynthetic Pathways: Camalexin and Beyond , 2013, Plant Cell.
[26] Dongwoo Nam,et al. Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. , 2013, Journal of ethnopharmacology.
[27] C. Buell,et al. Development of Transcriptomic Resources for Interrogating the Biosynthesis of Monoterpene Indole Alkaloids in Medicinal Plant Species , 2012, PloS one.
[28] K. Dou,et al. Swainsonine inhibits growth and potentiates the cytotoxic effect of paclitaxel in hepatocellular carcinoma in vitro and in vivo. , 2012, Oncology reports.
[29] L. Ellis,et al. Nanosponge-encapsulated camptothecin exerts anti-tumor activity in human prostate cancer cells. , 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[30] Yong Huang,et al. Swainsonine promotes apoptosis in human oesophageal squamous cell carcinoma cells in vitro and in vivo through activation of mitochondrial pathway , 2012, Journal of Biosciences.
[31] H. Dai,et al. Indole Alkaloids from Kopsia hainanensis and Evaluation of Their Antimicrobial Activity , 2012, Planta Medica.
[32] Wansheng Chen,et al. Overexpression of allene oxide cyclase promoted tanshinone/phenolic acid production in Salvia miltiorrhiza , 2012, Plant Cell Reports.
[33] Kexuan Tang,et al. Overexpression of ORCA3 and G10H in Catharanthus roseus Plants Regulated Alkaloid Biosynthesis and Metabolism Revealed by NMR-Metabolomics , 2012, PloS one.
[34] K. Berthelot,et al. Isopentenyl diphosphate isomerase: A checkpoint to isoprenoid biosynthesis. , 2012, Biochimie.
[35] J. Mach. No More Free Lunch: Using RNA Interference in the Host to Reduce Growth of a Parasitic Plant , 2012, Plant Cell.
[36] T. Winzer,et al. A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine , 2012, Science.
[37] V. De Luca,et al. Mining the Biodiversity of Plants: A Revolution in the Making , 2012, Science.
[38] J. Hartley,et al. Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells. , 2012, Phytomedicine : international journal of phytotherapy and phytopharmacology.
[39] W. Boland,et al. Plant defense against herbivores: chemical aspects. , 2012, Annual review of plant biology.
[40] P. Facchini,et al. Transcript and metabolite profiling in cell cultures of 18 plant species that produce benzylisoquinoline alkaloids. , 2012, Phytochemistry.
[41] V. Courdavault,et al. Molecular cloning and functional characterization of Catharanthus roseus hydroxymethylbutenyl 4-diphosphate synthase gene promoter from the methyl erythritol phosphate pathway , 2012, Molecular Biology Reports.
[42] Jin-Kyung Kim,et al. Indirubin-3-monoxime exhibits anti-inflammatory properties by down-regulating NF-κB and JNK signaling pathways in lipopolysaccharide-treated RAW264.7 cells , 2012, Inflammation Research.
[43] Yong Huang,et al. Swainsonine Activates Mitochondria-mediated Apoptotic Pathway in Human Lung Cancer A549 Cells and Retards the Growth of Lung Cancer Xenografts , 2012, International journal of biological sciences.
[44] I. Dubery,et al. Activation of camalexin biosynthesis in Arabidopsis thaliana in response to perception of bacterial lipopolysaccharides: a gene-to-metabolite study , 2012, Planta.
[45] Min Chen,et al. Tryptophan decarboxylase plays an important role in ajmalicine biosynthesis in Rauvolfia verticillata , 2012, Planta.
[46] S. O’Connor,et al. A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus. , 2011, Phytochemistry.
[47] Y. Li,et al. Pyrosequencing of the Camptotheca acuminata transcriptome reveals putative genes involved in camptothecin biosynthesis and transport , 2011, BMC Genomics.
[48] D. Gardner,et al. Increased antitumor efficacy by the combined administration of swainsonine and cisplatin in vivo. , 2011, Phytomedicine : international journal of phytotherapy and phytopharmacology.
[49] Jijin Gu,et al. Enhanced anti-tumor effect of 9-nitro-camptothecin complexed by hydroxypropyl-β-cyclodextrin and safety evaluation. , 2011, International journal of pharmaceutics.
[50] Yasuhiro Yamamoto,et al. 15-Deoxy-Δ12,14-prostaglandin J2 enhanced the anti-tumor activity of camptothecin against renal cell carcinoma independently of topoisomerase-II and PPARγ pathways. , 2011, Biochemical and biophysical research communications.
[51] P. Gantet,et al. The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus. , 2011, The Plant journal : for cell and molecular biology.
[52] Wanqi Liang,et al. Defective Pollen Wall Is Required for Anther and Microspore Development in Rice and Encodes a Fatty Acyl Carrier Protein Reductase[C][W][OA] , 2011, Plant Cell.
[53] C. Kuhlemeier,et al. Pollinator Choice in Petunia Depends on Two Major Genetic Loci for Floral Scent Production , 2011, Current Biology.
[54] I. Baldwin,et al. Trichome-derived O-acyl sugars are a first meal for caterpillars that tags them for predation , 2011, Proceedings of the National Academy of Sciences.
[55] A. Crozier,et al. Plant Metabolism and Biotechnology: Ashihara/Plant Metabolism and Biotechnology , 2011 .
[56] C. Buell,et al. A Stereoselective Hydroxylation Step of Alkaloid Biosynthesis by a Unique Cytochrome P450 in Catharanthus roseus* , 2011, The Journal of Biological Chemistry.
[57] Shu‐Ming Li,et al. Ergot alkaloids: structure diversity, biosynthetic gene clusters and functional proof of biosynthetic genes. , 2011, Natural product reports.
[58] Yuan Li,et al. Glutathione-Indole-3-Acetonitrile Is Required for Camalexin Biosynthesis in Arabidopsis thaliana[W][OA] , 2011, Plant Cell.
[59] D. Schriemer,et al. Integration of deep transcriptome and proteome analyses reveals the components of alkaloid metabolism in opium poppy cell cultures , 2010, BMC Plant Biology.
[60] G. Xia,et al. Cloning and Functional Analysis of Geraniol 10-Hydroxylase, a Cytochrome P450 from Swertia mussotii Franch , 2010, Bioscience, biotechnology, and biochemistry.
[61] E. Vranová,et al. The Arabidopsis thaliana FPP synthase isozymes have overlapping and specific functions in isoprenoid biosynthesis, and complete loss of FPP synthase activity causes early developmental arrest. , 2010, The Plant journal : for cell and molecular biology.
[62] H. Klee. Improving the flavor of fresh fruits: genomics, biochemistry, and biotechnology. , 2010, The New phytologist.
[63] R. Braz-Filho,et al. Rauvolfia Grandiflora (Apocynaceae) Extract Interferes With Staphylococcal Density, Enterotoxin Production And Antimicrobial Activity , 2010, Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology].
[64] M. J. Harrison,et al. Two Medicago truncatula Half-ABC Transporters Are Essential for Arbuscule Development in Arbuscular Mycorrhizal Symbiosis[W] , 2010, Plant Cell.
[65] G. Pasqua,et al. Cell-specific expression of tryptophan decarboxylase and 10-hydroxygeraniol oxidoreductase, key genes involved in camptothecin biosynthesis in Camptotheca acuminata Decne (Nyssaceae) , 2010, BMC Plant Biology.
[66] C. Ammer,et al. Targeted metabolite and transcript profiling for elucidating enzyme function: isolation of novel N-methyltransferases from three benzylisoquinoline alkaloid-producing species. , 2009, The Plant journal : for cell and molecular biology.
[67] Jiong Cai,et al. [Antineoplastic effect of koumine in mice bearing H22 solid tumor]. , 2009, Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
[68] D. Scheel,et al. The Multifunctional Enzyme CYP71B15 (PHYTOALEXIN DEFICIENT3) Converts Cysteine-Indole-3-Acetonitrile to Camalexin in the Indole-3-Acetonitrile Metabolic Network of Arabidopsis thaliana[W][OA] , 2009, The Plant Cell Online.
[69] K. San,et al. Transcriptional response of the terpenoid indole alkaloid pathway to the overexpression of ORCA3 along with jasmonic acid elicitation of Catharanthus roseus hairy roots over time. , 2009, Metabolic engineering.
[70] Yonghong Wang,et al. Arabidopsis indole synthase, a homolog of tryptophan synthase alpha, is an enzyme involved in the Trp-independent indole-containing metabolite biosynthesis. , 2008, Journal of integrative plant biology.
[71] F. Abdullaev,et al. Cytotoxicity of the beta-carboline alkaloids harmine and harmaline in human cell assays in vitro. , 2008, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
[72] Eve Syrkin Wurtele,et al. Articulation of three core metabolic processes in Arabidopsis: Fatty acid biosynthesis, leucine catabolism and starch metabolism , 2008, BMC Plant Biology.
[73] C. Pugliesi,et al. Alpha-tryptophan synthase of Isatis tinctoria: gene cloning and expression. , 2008, Plant physiology and biochemistry : PPB.
[74] G. Grynkiewicz,et al. Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugs. , 2008, Pharmacological reports : PR.
[75] A. Sinz. Die Bedeutung der Mutterkorn‐Alkaloide als Arzneistoffe. Weit mehr als nur α‐Blocker , 2008 .
[76] E. Fukusaki,et al. Overexpression of 1-Deoxy-D-xylulose-5-phosphate reductoisomerase gene in chloroplast contributes to increment of isoprenoid production. , 2008, Journal of bioscience and bioengineering.
[77] P. Facchini,et al. Alkaloid biosynthesis: metabolism and trafficking. , 2008, Annual review of plant biology.
[78] David G. I. Kingston,et al. Tubulin-interactive natural products as anticancer agents. , 2008, Journal of natural products.
[79] V. De Luca,et al. The Leaf Epidermome of Catharanthus roseus Reveals Its Biochemical Specialization[W][OA] , 2008, The Plant Cell Online.
[80] J. Koepke,et al. Molecular Architecture of Strictosidine Glucosidase: The Gateway to the Biosynthesis of the Monoterpenoid Indole Alkaloid Family[W] , 2007, The Plant Cell Online.
[81] Lin Li,et al. [Koumine-induced apoptosis of human colonic adenocarcinoma cells: the cell biological mechanism]. , 2007, Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
[82] G. Pasquali,et al. Identification of a Bipartite Jasmonate-Responsive Promoter Element in the Catharanthus roseus ORCA3 Transcription Factor Gene That Interacts Specifically with AT-Hook DNA-Binding Proteins1[W] , 2007, Plant Physiology.
[83] E. Glawischnig,et al. Regulatory variability of camalexin biosynthesis. , 2007, Journal of plant physiology.
[84] Anlong Xu,et al. β-Carboline Alkaloids: Biochemical and Pharmacological Functions , 2007 .
[85] K. Tang,et al. Molecular cloning and characterization of Crmdr1, a novel MDR-type ABC transporter gene from Catharanthus roseus , 2007, DNA sequence : the journal of DNA sequencing and mapping.
[86] E. Glawischnig,et al. The role of cytochrome P450 enzymes in the biosynthesis of camalexin. , 2006, Biochemical Society transactions.
[87] P. Schiff. Ergot and its alkaloids. , 2006, American journal of pharmaceutical education.
[88] Ji-Yun Kim,et al. Antimicrobial activity and cytotoxicity of bis(indole) alkaloids from the sponge Spongosorites sp. , 2006, Biological & pharmaceutical bulletin.
[89] F. Sato,et al. Characterization of Vacuolar Transport of the Endogenous Alkaloid Berberine in Coptis japonica1 , 2005, Plant Physiology.
[90] K. Yazaki. Transporters of secondary metabolites. , 2005, Current opinion in plant biology.
[91] K. Wakasa,et al. Identification of three shikimate kinase genes in rice: characterization of their differential expression during panicle development and of the enzymatic activities of the encoded proteins , 2005, Planta.
[92] P. Gantet,et al. CaaX-prenyltransferases are essential for expression of genes involvedin the early stages of monoterpenoid biosynthetic pathwayin Catharanthus roseus cells , 2005, Plant Molecular Biology.
[93] S. Moochhala,et al. Biologically active components of Physostigma venenosum. , 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[94] K. San,et al. Metabolic engineering of the indole pathway in Catharanthus roseus hairy roots and increased accumulation of tryptamine and serpentine. , 2004, Metabolic engineering.
[95] Dirk Inzé,et al. Plant cell factories in the post-genomic era: new ways to produce designer secondary metabolites. , 2004, Trends in plant science.
[96] B. G. Hansen,et al. Camalexin is synthesized from indole-3-acetaldoxime, a key branching point between primary and secondary metabolism in Arabidopsis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[97] V. Burlat,et al. Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid-derived primary metabolites. , 2004, The Plant journal : for cell and molecular biology.
[98] P. Broun. Transcription factors as tools for metabolic engineering in plants. , 2004, Current opinion in plant biology.
[99] Pascal Gantet,et al. Transcription factors: tools to engineer the production of pharmacologically active plant metabolites. , 2002, Trends in pharmacological sciences.
[100] L. Angenot,et al. Apoptosis of HL-60 leukemia cells induced by the bisindole alkaloids sungucine and isosungucine from Strychnos icaja. , 2002, Planta medica.
[101] J. Memelink,et al. Geraniol 10‐hydroxylase1, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis , 2001, FEBS letters.
[102] J. Tewksbury,et al. Seed dispersal: Directed deterrence by capsaicin in chillies , 2001, Nature.
[103] J. Memelink,et al. ORCAnization of jasmonate-responsive gene expression in alkaloid metabolism. , 2001, Trends in plant science.
[104] M. Clastre,et al. Cloning and expression of cDNAs encoding two enzymes of the MEP pathway in Catharanthus roseus. , 2000, Biochimica et biophysica acta.
[105] L. van der Fits,et al. ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism. , 2000, Science.
[106] D. Szymanski,et al. Progress in the molecular genetic analysis of trichome initiation and morphogenesis in Arabidopsis. , 2000, Trends in plant science.
[107] E. Martinoia,et al. A membrane-potential dependent ABC-like transporter mediates the vacuolar uptake of rye flavone glucuronides: regulation of glucuronide uptake by glutathione and its conjugates. , 2000, The Plant journal : for cell and molecular biology.
[108] Eugen C. Buehler,et al. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana , 1999, Nature.
[109] R. Last,et al. Characterization of tryptophan synthase alpha subunit mutants of Arabidopsis thaliana , 1996, Molecular and General Genetics MGG.
[110] K. Herrmann. The Shikimate Pathway: Early Steps in the Biosynthesis of Aromatic Compounds. , 1995, The Plant cell.
[111] G. Schröder,et al. Molecular Analysis and Heterologous Expression of an Inducible Cytochrome P-450 Protein from Periwinkle (Catharanthus roseus L.). , 1992, Plant physiology.
[112] D. McCaskill,et al. Characterization of Alkaloid Uptake by Catharanthus roseus (L.) G. Don Protoplasts. , 1988, Plant physiology.
[113] S. I. Kandel,et al. Biosynthesis of Ergot Alkaloids , 1960, Nature.
[114] J. B. Hanson,et al. Biosynthesis of Ergot Alkaloids1 , 1958 .
[115] Chen I-Chen,et al. Biosynthesis of fungal indole alkaloids , 2017 .
[116] M. Udvardi,et al. A high-throughput RNA interference (RNAi)-based approach using hairy roots for the study of plant-rhizobia interactions. , 2015, Methods in molecular biology.
[117] J. Lloyd,et al. Virus-induced gene silencing as a scalable tool to study drought tolerance in plants. , 2015, Methods in molecular biology.
[118] Z. Minić,et al. The phytoalexin camalexin induces fundamental changes in the proteome of Alternaria brassicicola different from those caused by brassinin. , 2014, Fungal biology.
[119] T. Shoji. ATP-binding cassette and multidrug and toxic compound extrusion transporters in plants: a common theme among diverse detoxification mechanisms. , 2014, International review of cell and molecular biology.
[120] A. Sugiyama,et al. Functional analysis of jasmonic acid-responsive secondary metabolite transporters. , 2013, Methods in molecular biology.
[121] K. Leung,et al. Indirubin-3'-oxime induces mitochondrial dysfunction and triggers growth inhibition and cell cycle arrest in human neuroblastoma cells. , 2013, Oncology reports.
[122] V. Salim,et al. Towards Complete Elucidation of Monoterpene Indole Alkaloid Biosynthesis Pathway: Catharanthus roseus as a Pioneer System , 2013 .
[123] Springer Basel Ag. Indirubin-3-monoxime exhibits anti-inflammatory properties by down-regulating NF-jB and JNK signaling pathways in lipopolysaccharide-treated RAW264.7 cells , 2012 .
[124] E. Glawischnig,et al. Inducible expression of a Nep1-like protein serves as a model trigger system of camalexin biosynthesis. , 2009, Phytochemistry.
[125] A. Sinz. [The development of ergot alkaloids as drugs]. , 2008, Pharmazie in unserer Zeit.
[126] A. Xu,et al. beta-Carboline alkaloids: biochemical and pharmacological functions. , 2007, Current medicinal chemistry.
[127] T. Hibino,et al. Na+/H+ antiporter from Synechocystis species PCC 6803, homologous to SOS1, contains an aspartic residue and long C-terminal tail important for the carrier activity. , 2001, Plant physiology.
[128] P. L. Quesne,et al. Biomimetic synthesis of the bisindole alkaloids villalstonine and alstonisidine , 1973 .