Studies on the mechanism of kinin formation in inflammation

1. Injection of autologous plasma into the subcutaneous space leads to kinin formation in man. Kinin formation was also observed after similar injections of homologous plasma in the rat, dog and guinea‐pig. The material withdrawn from the subcutaneous tissue following the injection of plasma was characterized as kinin by inhibition of its formation with trasylol, by inactivation with chymotrypsin and by its pharmacologic effects.