Knowledge Provenance Management System for a Dropwise Additive Manufacturing System for Pharmaceutical Products

The Knowledge Provenance Management System, KProMS, can capture the complete provenance of the data, information, and knowledge of a structured activity by modeling the details of the associated data generation steps of that activity as workflows. Its unique workflow representation captures relationships between the processing steps, material and information flows, and data input and output. In this paper, we demonstrate the use of KProMS to manage and analyze the experimental data of an innovative system for manufacturing drug products using dropwise additive manufacturing. Dropwise additive manufacturing of pharmaceutical products (DAMPP) uses drop on demand printing technology for depositing various drug formulations onto edible substrates. DAMPP requires and generates a range of data types, including camera and IR images, spectra, and numerical parameter values, both of real-time and off-line natures, and thus provide a rich illustration of KProMS capabilities to serve as knowledge management framework.

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