Potentials and emerging trends in nanopharmacology.

Nanopharmacology is a relatively newer branch of pharmacology which investigates interaction of a nanomedicine with living systems at the nanoscale level. Modern medicine is increasingly concerned with various surface modified nanocarriers, such as dendrimers, nanoparticles, carbon based nanomaterials, polymer-drug nanoconjugates, etc., which have immense therapeutic potential by target specific drug delivery, using nanoscaffolding and nanocontainers, owing to the specific physical, chemical and biological properties of these moieties that is related to their nanoscale size range. Nanopharmacology could have potential medical and pharmaceutical benefits via applications of nanotechnology in the delivery of therapeutic and diagnostic agents. Nanomaterials may be expected to find application in the cardiovascular, as well as, renal arena, in the near future.

[1]  Wanshan Ma,et al.  PEGylated Multi-Walled Carbon Nanotubes for Encapsulation and Sustained Release of Oxaliplatin , 2013, Pharmaceutical Research.

[2]  S. Feng,et al.  Nanopharmacology of liposomes developed for cancer therapy. , 2010, Nanomedicine.

[3]  P. Kesharwani,et al.  Dendrimer toxicity: Let's meet the challenge. , 2010, International journal of pharmaceutics.

[4]  Keerti Jain,et al.  Alginate coated chitosan core shell nanoparticles for oral delivery of enoxaparin: in vitro and in vivo assessment. , 2013, International journal of pharmaceutics.

[5]  M. Abdollahi,et al.  Different biokinetics of nanomedicines linking to their toxicity; an overview , 2013, DARU Journal of Pharmaceutical Sciences.

[6]  S. Logothetidis,et al.  Novel nanostructured biomaterials: implications for coronary stent thrombosis , 2012, International journal of nanomedicine.

[7]  N. Škalko-Basnet,et al.  New applications of phospholipid vesicle-based permeation assay: permeation model mimicking skin barrier. , 2013, Journal of pharmaceutical sciences.

[8]  H. Car,et al.  Nanoparticles as drug delivery systems , 2012, Pharmacological reports : PR.

[9]  L. Meng,et al.  Folate-conjugated PEG on single walled carbon nanotubes for targeting delivery of Doxorubicin to cancer cells. , 2013, Macromolecular bioscience.

[10]  T. Someya,et al.  Organic transistors with high thermal stability for medical applications , 2012, Nature Communications.

[11]  H. Lee,et al.  Stable and efficient delivery of docetaxel by micelle-encapsulation using a tripodal cyclotriphosphazene amphiphile. , 2012, International journal of pharmaceutics.

[12]  F. Zaini,et al.  Overexpression of aldo-keto-reductase in azole-resistant clinical isolates of Candida glabrata determined by cDNA-AFLP , 2013, DARU Journal of Pharmaceutical Sciences.

[13]  F. Greco,et al.  Janus PEG-based dendrimers for use in combination therapy: controlled multi-drug loading and sequential release. , 2013, Biomacromolecules.

[14]  A. Nel,et al.  Interlaboratory Evaluation of Rodent Pulmonary Responses to Engineered Nanomaterials: The NIEHS Nano GO Consortium , 2013, Environmental health perspectives.

[15]  Mingwu Shen,et al.  Folic acid-modified dendrimer-entrapped gold nanoparticles as nanoprobes for targeted CT imaging of human lung adencarcinoma. , 2013, Biomaterials.

[16]  S. Gambhir,et al.  A novel clinically translatable fluorescent nanoparticle for targeted molecular imaging of tumors in living subjects. , 2012, Nano letters.

[17]  M. Herrero,et al.  Enhanced docetaxel-mediated cytotoxicity in human prostate cancer cells through knockdown of cofilin-1 by carbon nanohorn delivered siRNA. , 2012, Biomaterials.

[18]  Baorui Liu,et al.  Enhanced antitumor efficacy, biodistribution and penetration of docetaxel-loaded biodegradable nanoparticles. , 2012, International journal of pharmaceutics.

[19]  N. Jain,et al.  Development of nanostructured lipid carriers for controlled delivery of mefenamic acid , 2012 .

[20]  Sarit S. Agasti,et al.  Controlled and Sustained Release of Drugs from Dendrimer–Nanoparticle Composite Films , 2011, Advanced materials.

[21]  Xin Gao,et al.  Dual docetaxel/superparamagnetic iron oxide loaded nanoparticles for both targeting magnetic resonance imaging and cancer therapy. , 2011, Biomaterials.

[22]  Seunghun Hong,et al.  "Chemical-pain sensor" based on nanovesicle-carbon nanotube hybrid structures. , 2013, Biosensors & bioelectronics.

[23]  A. Herrmann,et al.  DNA block copolymers: functional materials for nanoscience and biomedicine. , 2012, Accounts of chemical research.

[24]  Nanopharmacology: for the future-think small. , 2010, Clinical nurse specialist CNS.

[25]  U. Jana,et al.  Preparation and characterization of nebivolol nanoparticles using Eudragit® RS100. , 2014, Colloids and surfaces. B, Biointerfaces.

[26]  Dieter Haemmerich,et al.  Mild hyperthermia triggered doxorubicin release from optimized stealth thermosensitive liposomes improves intratumoral drug delivery and efficacy. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[27]  M. Prato,et al.  Translocation mechanisms of chemically functionalised carbon nanotubes across plasma membranes. , 2012, Biomaterials.

[28]  Sanyog Jain,et al.  Hyaluronate tethered, "smart" multiwalled carbon nanotubes for tumor-targeted delivery of doxorubicin. , 2012, Bioconjugate chemistry.

[29]  A. Zimmer,et al.  Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) for pulmonary application: a review of the state of the art. , 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[30]  L. Basabe‐Desmonts,et al.  From particle to platelet: optimization of a stable, high brightness fluorescent nanoparticle based cell detection platform. , 2013, Nanomedicine : nanotechnology, biology, and medicine.

[31]  W. Li,et al.  Surface-engineered gold nanorods: promising DNA vaccine adjuvant for HIV-1 treatment. , 2012, Nano letters.

[32]  Udita Agrawal,et al.  Hyperbranched dendritic nano-carriers for topical delivery of dithranol , 2013, Journal of drug targeting.

[33]  N. K. Jain,et al.  Development, characterization and cancer targeting potential of surface engineered carbon nanotubes , 2013, Journal of drug targeting.

[34]  C. Destache,et al.  A review of nanotechnological approaches for the prophylaxis of HIV/AIDS. , 2013, Biomaterials.

[35]  N. K. Jain,et al.  Novel therapeutic strategies for treatment of visceral leishmaniasis. , 2013, Drug discovery today.

[36]  R. Misra,et al.  A new family of folate-decorated and carbon nanotube-mediated drug delivery system: synthesis and drug delivery response. , 2011, Advanced drug delivery reviews.

[37]  Min Li,et al.  Synergistic enhancement of cancer therapy using a combination of docetaxel and photothermal ablation induced by single-walled carbon nanotubes , 2011, International journal of nanomedicine.

[38]  Walter Kolch,et al.  Big signals from small particles: regulation of cell signaling pathways by nanoparticles. , 2013, Chemical reviews.

[39]  Yu-Lan Hu,et al.  Glioma targeting and blood-brain barrier penetration by dual-targeting doxorubincin liposomes. , 2013, Biomaterials.

[40]  Xiaoling Fang,et al.  Anti-glioblastoma efficacy and safety of paclitaxel-loading Angiopep-conjugated dual targeting PEG-PCL nanoparticles. , 2012, Biomaterials.

[41]  Si-Shen Feng,et al.  Vitamin E TPGS coated liposomes enhanced cellular uptake and cytotoxicity of docetaxel in brain cancer cells. , 2011, International journal of pharmaceutics.

[42]  Michael E. Davis,et al.  Functionalized dendrimer-based delivery of angiotensin type 1 receptor siRNA for preserving cardiac function following infarction. , 2013, Biomaterials.

[43]  J. Ljubimova,et al.  Nanomedicine therapeutic approaches to overcome cancer drug resistance. , 2013, Advanced drug delivery reviews.

[44]  H. Gu,et al.  Fabrication of a novel polymer-free nanostructured drug-eluting coating for cardiovascular stents. , 2013, ACS applied materials & interfaces.

[45]  N. K. Jain,et al.  Paclitaxel loaded PEGylated gleceryl monooleate based nanoparticulate carriers in chemotherapy. , 2012, Biomaterials.

[46]  F Atyabi,et al.  Increased paclitaxel cytotoxicity against cancer cell lines using a novel functionalized carbon nanotube , 2011, International journal of nanomedicine.

[47]  Alexander T Florence,et al.  "Targeting" nanoparticles: the constraints of physical laws and physical barriers. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[48]  N. K. Jain,et al.  A review of ligand tethered surface engineered carbon nanotubes. , 2014, Biomaterials.

[49]  Keerti Jain,et al.  Lipoproteins tethered dendrimeric nanoconstructs for effective targeting to cancer cells , 2013, Journal of Nanoparticle Research.

[50]  N. Jain,et al.  Surface engineered dendrimers as antiangiogenic agent and carrier for anticancer drug: dual attack on cancer. , 2014, Journal of nanoscience and nanotechnology.