Serine beta-lactamases and penicillin-binding proteins.

The Penicillin-Interactive, Active-Site Serine Protein Family . . . . . .... . . . . .. . . . . . . . . . . . . . 37 The Low-Mr PBPs . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . .... . . . . . . ... . . . . . . . . .. . . . . . . . . . . . . .. . . . . . . . . . . . 45 The (3-Lactamases and the Penicillin Sensory-Transducer BLAR ...... . . 47 The Atomic-Level Enzyme-Ligand Interactions . . . . . .. . . . . . . . . . .. . . . . . . . .. . . . . . . . . . .. . . . . . . . . 50 The High-Mr PBPs of Class A and B .... . . . . . . . ...... . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . .. . . . . . . . 54 Intrinsic Resistance by Emergence of Altered High-Mr PBPs . .. . . . . . . . . . . . . . . . . .. . .. . . . 58