The evaluation of radioactive microsphere data: remarks on the use of the BMDP and SAS statistical software packages.

We investigated the suitability of BMDP and SAS as an integrated tool for the evaluation of regional blood flow data obtained from the radioactive microsphere technique. Both packages were applied to a recent study on muscle blood flow with a 3-factorial design. The organization of data and files, the strategy of data reduction, and the evaluation by means of statistical and graphical techniques are shown. The method may be applied to any microsphere study design. A considerable amount of time can be saved and data integrity may be improved. The statistical quality of the results may benefit from the broad spectrum of statistical tests available.

[1]  C. Hofacker.  Abuse of statistical packages: the case of the general linear model. , 1983, The American journal of physiology.

[2]  R. Blantz,et al.  Geometric error in tissue gamma-counting: methods for minimization. , 1972, Journal of applied physiology.

[3]  A M Rudolph,et al.  The Circulation of the Fetus in Utero: Methods For Studying Distribution of Blood Flow, Cardiac Output And Organ Blood Flow , 1967, Circulation research.

[4]  J B Bassingthwaighte,et al.  Stability of heterogeneity of myocardial blood flow in normal awake baboons. , 1985, Circulation research.

[5]  Wayne A. Woodward,et al.  A survey of statistical packages on microcomputers , 1983 .

[6]  W. P. Dixon,et al.  BMPD statistical software manual , 1988 .

[7]  Ivor Francis,et al.  A survey of statistical software , 1983 .

[8]  K. Messmer,et al.  MIC-II - a program for the determination of cardiac output, arterio-venous shunt and regional blood flow using the radioactive microsphere method. , 1979, Computer programs in biomedicine.

[9]  J I Hoffman,et al.  Blood flow measurements with radionuclide-labeled particles. , 1977, Progress in cardiovascular diseases.

[10]  G. Vlahakes,et al.  Increased number of myocardial blood flow measurements with radionuclide-labeled microspheres. , 1984, The American journal of physiology.

[11]  J. Fleiss,et al.  Some Statistical Methods Useful in Circulation Research , 1980, Circulation research.

[12]  J I Hoffman,et al.  Some sources of error in measuring regional blood flow with radioactive microspheres. , 1971, Journal of applied physiology.

[13]  V. Denenberg.  Some statistical and experimental considerations in the use of the analysis-of-variance procedure. , 1984, The American journal of physiology.

[14]  S. Glantz.  Biostatistics: how to detect, correct and prevent errors in the medical literature. , 1980, Circulation.

[15]  K. Messmer,et al.  Tissue pO2 and Transcutaneous pO2 as Guidelines in Experimental and Clinical Drug Evaluation , 1981, Angiology.

[16]  Multiple cerebral and spinal cord blood flow measurements using the radioactive microsphere method. , 1979, Bibliotheca anatomica.