Bioluminescence and its impact on bioanalysis.

There is an increasing need for versatile yet sensitive labels, posed by the demands for low detection in bioanalysis. Bioluminescent proteins have many desirable characteristics, including the ability to be detected at extremely low concentrations; no background interference from autofluorescent compounds present in samples; and compatibility with many miniaturized platforms, such as lab-on-a-chip and lab-on-a-CD systems. Bioluminescent proteins have found a plethora of analytical applications in intracellular monitoring, genetic regulation and detection, immuno- and binding assays, and whole-cell biosensors, among others. As new bioluminescent organisms are discovered and new bioluminescence proteins are characterized, use of these proteins will continue to dramatically improve our understanding of molecular and cellular events, as well as their applications for detection of environmental and biomedical samples.

[1]  J. Rolain,et al.  New insights into the antibacterial mechanism of action of squalamine. , 2010, The Journal of antimicrobial chemotherapy.

[2]  S. Daunert,et al.  Packaging sensing cells in spores for long-term preservation of sensors: a tool for biomedical and environmental analysis. , 2010, Analytical chemistry.

[3]  J. Rao,et al.  Near-infrared light emitting luciferase via biomineralization. , 2010, Journal of the American Chemical Society.

[4]  S. Daunert,et al.  Modulating the bioluminescence emission of photoproteins by in vivo site-directed incorporation of non-natural amino acids. , 2010, ACS chemical biology.

[5]  E. Widder,et al.  Bioluminescence in the Ocean: Origins of Biological, Chemical, and Ecological Diversity , 2010, Science.

[6]  K. Fuxe,et al.  Cocaine produces D2R-mediated conformational changes in the adenosine A(2A)R-dopamine D2R heteromer. , 2010, Biochemical and biophysical research communications.

[7]  K. Miura,et al.  Rapid and high-sensitivity cell-based assays of protein-protein interactions using split click beetle luciferase complementation: an approach to the study of G-protein-coupled receptors. , 2010, Analytical chemistry.

[8]  Jennifer A. Prescher,et al.  Guided by the light: visualizing biomolecular processes in living animals with bioluminescence. , 2010, Current Opinion in Chemical Biology.

[9]  S. Daunert,et al.  Engineering bioluminescent proteins: expanding their analytical potential. , 2009, Analytical chemistry.

[10]  D. Lerner,et al.  Optimization of bacterial whole cell bioreporters for toxicity assay of environmental samples. , 2009, Environmental science & technology.

[11]  Hui Chen,et al.  Immunomagnetic separation and rapid detection of bacteria using bioluminescence and microfluidics. , 2009, Talanta.

[12]  Abhijit De,et al.  BRET3: a red‐shifted bioluminescence resonance energy transfer (BRET)‐based integrated platform for imaging protein‐protein interactions from single live cells and living animals , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[13]  P. Krogsgaard‐Larsen,et al.  Detecting Protein–Protein Interactions in Living Cells: Development of a Bioluminescence Resonance Energy Transfer Assay to Evaluate the PSD-95/NMDA Receptor Interaction , 2009, Neurochemical Research.

[14]  S. Daunert,et al.  Aequorin variants with improved bioluminescence properties. , 2009, Protein engineering, design & selection : PEDS.

[15]  Elisa Michelini,et al.  Bioluminescence in analytical chemistry and in vivo imaging , 2009 .

[16]  Jianghong Rao,et al.  Biosensing and imaging based on bioluminescence resonance energy transfer. , 2009, Current opinion in biotechnology.

[17]  A. Kuroda,et al.  Detection of living Salmonella cells using bioluminescence , 2009, Biotechnology Letters.

[18]  Shimshon Belkin,et al.  Modeling and measurement of a whole-cell bioluminescent biosensor based on a single photon avalanche diode. , 2008, Biosensors & bioelectronics.

[19]  M. Brini.  Calcium-sensitive photoproteins. , 2008, Methods.

[20]  P. Weiss.  2008 Nobel Prize in Chemistry: green fluorescent protein, its variants and implications. , 2008, ACS nano.

[21]  S. Daunert,et al.  Genetically modified semisynthetic bioluminescent photoprotein variants: simultaneous dual-analyte assay in a single well employing time resolution of decay kinetics. , 2008, Analytical chemistry.

[22]  John G. Lee.  Bioluminescence: the First 3000 Years (Review) , 2008 .

[23]  F. Nagatsugi,et al.  Synthesis and Evaluation of the Luciferase‐Oligodeoxynucleotide for the Sequence‐Selective Detection of Nucleic Acids , 2008, Archiv der Pharmazie.

[24]  M. Maeda,et al.  Development of bioluminescent pyrophosphate assay using pyruvate phosphate dikinase and its application to single-nucleotide polymorphism analysis. , 2008, Analytical biochemistry.

[25]  T. K. Christopoulos,et al.  Dry‐reagent disposable biosensor for visual genotyping of single nucleotide polymorphisms by oligonucleotide ligation reaction: application to pharmacogenetic analysis , 2008, Human mutation.

[26]  S. Deo.  Jacquie T. Keer and Lyndsey Birch (Eds.): Essentials of nucleic acid analysis. A robust approach , 2008 .

[27]  S. Markova,et al.  Violet and greenish photoprotein obelin mutants for reporter applications in dual-color assay , 2008, Analytical and bioanalytical chemistry.

[28]  S. Inouye,et al.  Recombinant aequorin with a reactive cysteine residue for conjugation with maleimide-activated antibody. , 2008, Analytical biochemistry.

[29]  S. Deo,et al.  Rapid, single-step nucleic acid detection , 2008, Analytical and bioanalytical chemistry.

[30]  N. Elman,et al.  Towards toxicity detection using a lab-on-chip based on the integration of MOEMS and whole-cell sensors. , 2008, Biosensors & bioelectronics.

[31]  M. Bouvier,et al.  Bioluminescence Resonance Energy Transfer Assays Reveal Ligand-specific Conformational Changes within Preformed Signaling Complexes Containing δ-Opioid Receptors and Heterotrimeric G Proteins* , 2008, Journal of Biological Chemistry.

[32]  S. Daunert,et al.  A bioluminescent molecular switch for glucose. , 2008, Angewandte Chemie.

[33]  Indraneel Ghosh,et al.  A general and rapid cell-free approach for the interrogation of protein-protein, protein-DNA, and protein-RNA interactions and their antagonists utilizing split-protein reporters. , 2008, Journal of the American Chemical Society.

[34]  B. Polyak,et al.  Bioluminescent Whole-Cell Optical Fiber Sensors , 2008 .

[35]  A. Ivask,et al.  Recombinant whole-cell bioreporter systems based on beetle luciferases , 2008 .

[36]  A. Roda,et al.  Luminescent Proteins in Binding Assays , 2008 .

[37]  Despina P Kalogianni,et al.  Advances in molecular techniques for the detection and quantification of genetically modified organisms , 2008, Analytical and bioanalytical chemistry.

[38]  H. Fraga.  Firefly luminescence: A historical perspective and recent developments , 2008, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[39]  S. Daunert,et al.  Bioluminescence immunoassay for angiotensin II using aequorin as a label. , 2007, Analytical biochemistry.

[40]  Sylvia Daunert,et al.  Construction of spores for portable bacterial whole-cell biosensing systems. , 2007, Analytical chemistry.

[41]  Kendrick B. Turner,et al.  Hydroxylated polychlorinated biphenyl detection based on a genetically engineered bioluminescent whole-cell sensing system. , 2007, Analytical chemistry.

[42]  S. Deo,et al.  MicroRNA Detection: Challenges for the Analytical Chemist , 2007 .

[43]  S. Daunert,et al.  Bioluminescence DNA hybridization assay for Plasmodium falciparum based on the photoprotein aequorin. , 2007, Analytical chemistry.

[44]  S. Inouye,et al.  Highly sensitive and rapid tandem bioluminescent immunoassay using aequorin labeled Fab fragment and biotinylated firefly luciferase. , 2007, Analytica chimica acta.

[45]  S. Hecht,et al.  Site-specific incorporation of glycosylated serine and tyrosine derivatives into proteins. , 2007, Journal of the American Chemical Society.

[46]  Y. Ohmiya,et al.  Preparation of biotinylated cypridina luciferase and its use in bioluminescent enzyme immunoassay. , 2007, Analytical chemistry.

[47]  Sylvia Daunert,et al.  Biosensing systems for the detection of bacterial quorum signaling molecules. , 2006, Analytical chemistry.

[48]  Sanjiv S Gambhir,et al.  Creating self-illuminating quantum dot conjugates , 2006, Nature Protocols.

[49]  S. Daunert,et al.  PHOTOPROTEINS IN BIOANALYSIS , 2006 .

[50]  S. Daunert,et al.  Luminescent Proteins: Applications in Microfluidics and Miniaturized Analytical Systems , 2006 .

[51]  E. Karplus.  Advances in Instrumentation for Detecting Low‐level Bioluminescence and Fluorescence , 2006 .

[52]  Y. Ohmiya,et al.  Beetle Luciferases: Colorful Lights on Biological Processes and Diseases , 2006 .

[53]  A. Roda,et al.  Bioluminescent Biosensors Based on Genetically Engineered Living Cells in Environmental and Food Analysis , 2006 .

[54]  Adrian Saldanha,et al.  Structural basis for the spectral difference in luciferase bioluminescence , 2006, Nature.

[55]  T. K. Christopoulos,et al.  Photoprotein aequorin as a novel reporter for SNP genotyping by primer extension–application to the variants of mannose‐binding lectin gene , 2006, Human mutation.

[56]  Sanjiv S Gambhir,et al.  Self-illuminating quantum dot conjugates for in vivo imaging , 2006, Nature Biotechnology.

[57]  Elisa Michelini,et al.  Red- and green-emitting firefly luciferase mutants for bioluminescent reporter applications. , 2005, Analytical biochemistry.

[58]  Sanjiv S Gambhir,et al.  Novel fusion protein approach for efficient high-throughput screening of small molecule-mediating protein-protein interactions in cells and living animals. , 2005, Cancer research.

[59]  Ronald W. Davis,et al.  Bioluminescence regenerative cycle (BRC) system: theoretical considerations for nucleic acid quantification assays. , 2005, Biophysical chemistry.

[60]  C. Oxvig,et al.  Real-time measurement in living cells of insulin-like growth factor activity using bioluminescence resonance energy transfer. , 2005, Biochemical pharmacology.

[61]  T. Ozawa.  Methods of Analysis for Protein Dynamics in Living Cells Based on Protein Splicing , 2005 .

[62]  E. N. Harvey,et al.  A History of Luminescence: From the Earliest Times Until 1900 , 2005 .

[63]  E. Vysotski,et al.  CALCIUM-REGULATED PHOTOPROTEIN OBELIN AS A LABEL IN IMMUNOASSAY: AN OUTLOOK FOR APPLICATIONS , 2005 .

[64]  R. Weissleder,et al.  Codon-optimized Gaussia luciferase cDNA for mammalian gene expression in culture and in vivo. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

[65]  Qingming Luo,et al.  Microfluidic chip toward cellular ATP and ATP-conjugated metabolic analysis with bioluminescence detection. , 2005, Analytical chemistry.

[66]  R. Tsien,et al.  Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein , 2004, Nature Biotechnology.

[67]  S. Sarter,et al.  Chemiluminescent and bioluminescent assays as innovative prospects for mycotoxin determination in food and feed. , 2004, Luminescence : the journal of biological and chemical luminescence.

[68]  Y. Umezawa,et al.  High-throughput sensing and noninvasive imaging of protein nuclear transport by using reconstitution of split Renilla luciferase. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[69]  S. Ghoshal,et al.  Characterization of a new solvent-responsive gene locus in Pseudomonas putida F1 and its functionalization as a versatile biosensor. , 2003, Environmental microbiology.

[70]  M. L. Simpson,et al.  Bioluminescent bioreporter integrated-circuit sensing of microbial volatile organic compounds , 2003, Journal of Industrial Microbiology and Biotechnology.

[71]  Y. Umezawa,et al.  Locating a protein-protein interaction in living cells via split Renilla luciferase complementation. , 2003, Analytical chemistry.

[72]  S. Belkin.  Microbial whole-cell sensing systems of environmental pollutants. , 2003, Current opinion in microbiology.

[73]  Sylvia Daunert,et al.  Luminescence-based whole-cell-sensing systems for cadmium and lead using genetically engineered bacteria , 2003, Analytical and bioanalytical chemistry.

[74]  M. Dollard,et al.  Assessment of heavy metal bioavailability using Escherichia colizntAp::lux and copAp::lux-based biosensors , 2001, Applied Microbiology and Biotechnology.

[75]  A. Kenworthy,et al.  Imaging protein-protein interactions using fluorescence resonance energy transfer microscopy. , 2001, Methods.

[76]  Y. Umezawa,et al.  Split luciferase as an optical probe for detecting protein-protein interactions in mammalian cells based on protein splicing. , 2001, Analytical chemistry.

[77]  K E Fogarty,et al.  Recombinant aequorin and green fluorescent protein as valuable tools in the study of cell signalling. , 2001, The Biochemical journal.

[78]  K Slater,et al.  Cytotoxicity tests for high-throughput drug discovery. , 2001, Current opinion in biotechnology.

[79]  S. Sørensen,et al.  Detection and quantification of tetracyclines by whole cell biosensors. , 2000, FEMS microbiology letters.

[80]  S. Forsythe,et al.  Adenylate kinase amplification of ATP bioluminescence for hygiene monitoring in the food and beverage industry , 2000, Letters in applied microbiology.

[81]  F. Prendergast.  Structural biology: Bioluminescence illuminated , 2000, Nature.

[82]  J. Kendall,et al.  Aequorea victoria bioluminescence moves into an exciting new era. , 1998, Trends in biotechnology.

[83]  M. Muccini,et al.  Construction of a Bioluminescent Reporter Strain To Detect Polychlorinated Biphenyls , 1998, Applied and Environmental Microbiology.

[84]  M Virta,et al.  Luminescent bacterial sensor for cadmium and lead. , 1998, Biosensors & bioelectronics.

[85]  S. Daunert,et al.  Sensing antimonite and arsenite at the subattomole level with genetically engineered bioluminescent bacteria. , 1997, Analytical chemistry.

[86]  P E Stanley,et al.  Commercially available luminometers and imaging devices for low-light level measurements and kits and reagents utilizing bioluminescence or chemiluminescence: survey update 2. , 1996, Journal of bioluminescence and chemiluminescence.

[87]  M. Chalfie,et al.  Green fluorescent protein as a marker for gene expression. , 1994, Science.

[88]  R. Burlage,et al.  Bioluminescent sensors for detection of bioavailable Hg(II) in the environment , 1993, Applied and environmental microbiology.

[89]  E. Meighen,et al.  Bacterial bioluminescence: organization, regulation, and application of the lux genes , 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[90]  T. Rink.  Receptor‐mediated calcium entry , 1990, FEBS letters.

[91]  O. Shimomura,et al.  Semi-synthetic aequorin. An improved tool for the measurement of calcium ion concentration. , 1988, The Biochemical journal.

[92]  O. Shimomura,et al.  Extraction, purification and properties of aequorin, a bioluminescent protein from the luminous hydromedusan, Aequorea. , 1962, Journal of cellular and comparative physiology.

[93]  M. Moline,et al.  Bioluminescence in the sea. , 2010, Annual review of marine science.

[94]  J. Brunel,et al.  A comparison of three rapid and accurate bioluminescent antibiotic susceptibility tests. , 2010, Journal of pharmacological and toxicological methods.

[95]  J. García-Sancho,et al.  Bioluminescence imaging of calcium oscillations inside intracellular organelles. , 2009, Methods in molecular biology.

[96]  A. Roda,et al.  Luminescent probes and visualization of bioluminescence. , 2009, Methods in molecular biology.

[97]  S. Deo,et al.  Resonance energy transfer methods of RNA detection , 2009, Analytical and bioanalytical chemistry.

[98]  A. Roda,et al.  Nanobioanalytical luminescence: Förster-type energy transfer methods , 2009, Analytical and bioanalytical chemistry.

[99]  Sung Bae Kim,et al.  Split Gaussia luciferase-based bioluminescence template for tracing protein dynamics in living cells. , 2009, Analytical chemistry.

[100]  C. Jonsson,et al.  A cell-based luminescence assay is effective for high-throughput screening of potential influenza antivirals. , 2007, Antiviral research.

[101]  J. W. Hastings.  Biological diversity, chemical mechanisms, and the evolutionary origins of bioluminescent systems , 2005, Journal of Molecular Evolution.

[102]  J. W. Hastings,et al.  Chemistries and colors of bioluminescent reactions: a review. , 1996, Gene.