Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway.
暂无分享,去创建一个
Bing-Hua Jiang | Y. Rojanasakul | B. Jiang | Jing Fang | Q. Meng | Yon Rojanasakul | Jing Fang | Qiao Meng | Chang Xia | Chang Xia
[1] Mario Mellado,et al. Role of the Pi3k Regulatory Subunit in the Control of Actin Organization and Cell Migration , 2000, The Journal of cell biology.
[2] M. Crouch,et al. Cellular function of p70S6K: A role in regulating cell motility , 2000, Immunology and cell biology.
[3] M. Waterfield,et al. Signaling by distinct classes of phosphoinositide 3-kinases. , 1999, Experimental cell research.
[4] A. Okamoto,et al. Allelic imbalance and mutations of the PTEN gene in ovarian cancer , 2000, International journal of cancer.
[5] M. Crouch,et al. Nitric oxide induces polarization of actin in encephalitogenic T cells and inhibits their in vitro transendothelial migration in a p70S6 kinase‐independent manner , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[6] D. Roymans,et al. Phosphatidylinositol 3-kinases in tumor progression. , 2001, European journal of biochemistry.
[7] A. Toker,et al. Signalling through the lipid products of phosphoinositide-3-OH kinase , 1997, Nature.
[8] Taylor Murray,et al. Cancer Statistics, 2001 , 2001, CA: a cancer journal for clinicians.
[9] G. Macino,et al. Post-transcriptional gene silencing across kingdoms. , 2000, Current opinion in genetics & development.
[10] D. Engelke,et al. Effective expression of small interfering RNA in human cells , 2002, Nature Biotechnology.
[11] J. Woodgett,et al. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. , 1998, The Biochemical journal.
[12] J. Cheng,et al. Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas , 1995, International journal of cancer.
[13] J. Slingerland,et al. The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer. , 1999, Annual review of medicine.
[14] Andrew K Godwin,et al. AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth , 2004, Oncogene.
[15] G. Mills,et al. Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models. , 2002, Cancer research.
[16] R. Pearson,et al. Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k , 1997, The EMBO journal.
[17] S. Rudikoff,et al. Insulin-like growth factor I induces migration and invasion of human multiple myeloma cells. , 2004, Blood.
[18] D. Lauffenburger,et al. Cell Migration: A Physically Integrated Molecular Process , 1996, Cell.
[19] U. Puistola,et al. Ovarian cancer cell invasion is inhibited by paclitaxel , 1997, Clinical & Experimental Metastasis.
[20] G. Mills,et al. In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002). , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[21] Jiahuai Han,et al. Myogenic differentiation requires signalling through both phosphatidylinositol 3-kinase and p38 MAP kinase. , 2000, Cellular signalling.
[22] T. Tuschl,et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells , 2001, Nature.
[23] R. Ozols,et al. Ovarian cancer biology. , 1991, Seminars in oncology.
[24] M. Andjelkovic,et al. Phosphorylation and activation of p70s6k by PDK1. , 1998, Science.
[25] D. Tindall,et al. Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer. , 1998, International journal of oncology.
[26] Amy A. Caudy,et al. Post-transcriptional gene silencing by double-stranded RNA , 2001, Nature Reviews Genetics.
[27] J. Hauser,et al. Autocrine Transforming Growth Factor α Regulates Cell Adhesion by Multiple Signaling via Specific Phosphorylation Sites of p70S6 Kinase in Colon Cancer Cells* , 2004, Journal of Biological Chemistry.
[28] J. Ptak,et al. High Frequency of Mutations of the PIK3CA Gene in Human Cancers , 2004, Science.
[29] C. Sawyers,et al. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer , 2002, Nature Reviews Cancer.
[30] K. Taira,et al. U6 promoter–driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells , 2002, Nature Biotechnology.
[31] Joe W. Gray,et al. PIK3CA is implicated as an oncogene in ovarian cancer , 1999, Nature Genetics.
[32] J. Blenis,et al. Nuclear localization and regulation of erk- and rsk-encoded protein kinases , 1992, Molecular and cellular biology.
[33] Yan Shi,et al. Rapamycin inhibits Akt-mediated oncogenic transformation and tumor growth. , 2004, Anticancer research.
[34] J E Paciga,et al. AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. , 2001, The American journal of pathology.
[35] J. Blenis,et al. The p70S6K signalling pathway: a novel signalling system involved in growth regulation. , 1996, Cancer surveys.
[36] G. Mills,et al. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. , 1997, Cancer research.