Facile synthesis of 2-C-methyl-d-arabino-γ-1,4-lactones and mechanism study

[1]  J. Bilello,et al.  The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-α-chloro-2'-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors. , 2017, Bioorganic & medicinal chemistry letters.

[2]  Xiangrui Jiang,et al.  Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review. , 2016, Current drug targets.

[3]  R. Reddi,et al.  Regioselective Oxo-Amination of Alkenes and Enol Ethers with N-Bromosuccinimide-Dimethyl Sulfoxide Combination: A Facile Synthesis of α-Amino-Ketones and Esters. , 2016, Organic letters.

[4]  M. Norkin,et al.  Sapacitabine in the treatment of acute myeloid leukemia , 2015, Expert review of anticancer therapy.

[5]  Xiangrui Jiang,et al.  A neighboring group participation strategy: facile synthesis of 3,5-di-O-benzoyl-2-C-methyl-d-arabino-γ-lactone , 2015 .

[6]  Jie Wu,et al.  Synthesis and biological evaluation of 4-substituted fluoronucleoside analogs for the treatment of hepatitis B virus infection. , 2015, Journal of medicinal chemistry.

[7]  Liming Zhang.  A Non-Diazo Approach to α-Oxo Gold Carbenes via Gold-Catalyzed Alkyne Oxidation , 2014, Accounts of chemical research.

[8]  M. Rodríguez-Torres.  Sofosbuvir (GS-7977), a pan-genotype, direct-acting antiviral for hepatitis C virus infection , 2013, Expert review of anti-infective therapy.

[9]  Fabien Zoulim,et al.  Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases , 2013, Nature Reviews Drug Discovery.

[10]  M. Sofia,et al.  Stereoselective synthesis of PSI-352938: a β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methyl-3',5'-cyclic phosphate nucleotide prodrug for the treatment of HCV. , 2011, The Journal of organic chemistry.

[11]  M. Otto,et al.  Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. , 2010, Journal of medicinal chemistry.

[12]  Liming Zhang,et al.  Gold-catalyzed intramolecular redox reaction of sulfinyl alkynes: efficient generation of alpha-oxo gold carbenoids and application in insertion into R--CO bonds. , 2007, Angewandte Chemie.

[13]  P. D. Cook,et al.  Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication. , 2004, Journal of medicinal chemistry.

[14]  V. P. Dutta,et al.  Bromohydrin formation in dimethyl sulfoxide , 1968 .

[15]  R. Hodge.  Meeting report: 29th International Conference on Antiviral Research in La Jolla, CA, USA. , 2017 .