Enterobacter cloacae producing an uncommon class A carbapenemase, IMI-1, from Singapore.

In this study, we describe the characterization of an infrequently encountered class A carbapenemase, IMI-1, from a clinical Enterobacter cloacae isolate. The isolate had high levels of resistance to carbapenems but retained susceptibility to expanded-spectrum cephalosporins. The blaIMI-1 gene was chromosomally encoded. Detection of the IMI-1 producer highlights the diversity of carbapenemases in a local clinical setting.

[1]  R. Lin,et al.  Molecular characterization of NDM-1 producing Enterobacteriaceae isolates in Singapore hospitals. , 2012, Western Pacific surveillance and response journal : WPSAR.

[2]  P. Nordmann,et al.  First Identification of blaIMI-1 in an Enterobacter cloacae Clinical Isolate from France , 2011, Antimicrobial Agents and Chemotherapy.

[3]  C. Torres,et al.  First Detection of blaIMI-2 Gene in a Clinical Escherichia coli Strain , 2011, Antimicrobial Agents and Chemotherapy.

[4]  Thierry Naas,et al.  Global Spread of Carbapenemase-producing Enterobacteriaceae , 2011, Emerging infectious diseases.

[5]  M. Chu,et al.  Carbapenemases in Enterobacteria, Hong Kong, China, 2009 , 2011, Emerging infectious diseases.

[6]  N. Woodford,et al.  Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. , 2006, International journal of antimicrobial agents.

[7]  P. Nordmann,et al.  Carbapenemase-producing Enterobacteriaceae, U.S. Rivers , 2005, Emerging infectious diseases.

[8]  A. Medeiros,et al.  Characterization of IMI-1 beta-lactamase, a class A carbapenem-hydrolyzing enzyme from Enterobacter cloacae , 1996, Antimicrobial agents and chemotherapy.

[9]  G. P. Harding,et al.  A general method for detecting and sizing large plasmids. , 1995, Analytical biochemistry.