Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification.

[1]  Olivier Pourquié,et al.  Making muscle: skeletal myogenesis in vivo and in vitro , 2017, Development.

[2]  V. Papaioannou,et al.  Cell lineage of timed cohorts of Tbx6-expressing cells in wild-type and Tbx6 mutant embryos , 2017, Biology Open.

[3]  N. Matsumoto,et al.  Compound Heterozygosity for Null Mutations and a Common Hypomorphic Risk Haplotype in TBX6 Causes Congenital Scoliosis , 2017, Human mutation.

[4]  Pang Wei Koh,et al.  Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types , 2016, Cell.

[5]  Nicola K. Wilson,et al.  Resolving Early Mesoderm Diversification through Single Cell Expression Profiling , 2016, Nature.

[6]  Sebastian A. Leidel,et al.  Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs. , 2016, Cell stem cell.

[7]  R. Stewart,et al.  Development of Bipotent Cardiac/Skeletal Myogenic Progenitors from MESP1+ Mesoderm , 2016, Stem cell reports.

[8]  T. Furukawa,et al.  Fibroblast Growth Factors and Vascular Endothelial Growth Factor Promote Cardiac Reprogramming under Defined Conditions , 2015, Stem cell reports.

[9]  Olivier Tassy,et al.  Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy , 2015, Nature Biotechnology.

[10]  S. Yamanaka,et al.  Direct cardiac reprogramming: progress and challenges in basic biology and clinical applications. , 2015, Circulation research.

[11]  S. Yuasa,et al.  A Massive Suspension Culture System With Metabolic Purification for Human Pluripotent Stem Cell‐Derived Cardiomyocytes , 2014, Stem cells translational medicine.

[12]  J. Kleinjung,et al.  In Vitro Generation of Neuromesodermal Progenitors Reveals Distinct Roles for Wnt Signalling in the Specification of Spinal Cord and Paraxial Mesoderm Identity , 2014, PLoS biology.

[13]  Keiichi Fukuda,et al.  MiR‐133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures , 2014, The EMBO journal.

[14]  B. Cui,et al.  Chemically Defined and Small Molecule-Based Generation of Human Cardiomyocytes , 2014, Nature methods.

[15]  P. Gunaratne,et al.  Mesp1 Marked Cardiac Progenitor Cells Repair Infarcted Mouse Hearts , 2013, Scientific Reports.

[16]  David A. Scott,et al.  Genome engineering using the CRISPR-Cas9 system , 2013, Nature Protocols.

[17]  M. Kyba,et al.  TBX3 Directs Cell-Fate Decision toward Mesendoderm , 2013, Stem cell reports.

[18]  B. Alman,et al.  Specification of chondrocytes and cartilage tissues from embryonic stem cells , 2013, Development.

[19]  Daniel J Garry,et al.  Mesp1 patterns mesoderm into cardiac, hematopoietic, or skeletal myogenic progenitors in a context-dependent manner. , 2013, Cell Stem Cell.

[20]  Le Cong,et al.  Multiplex Genome Engineering Using CRISPR/Cas Systems , 2013, Science.

[21]  Alexander R. Pico,et al.  Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage , 2012, Cell.

[22]  Sean Thomas,et al.  A Temporal Chromatin Signature in Human Embryonic Stem Cells Identifies Regulators of Cardiac Development , 2012, Cell.

[23]  C. Mummery,et al.  Tbx6 is a determinant of cardiac and neural cell fate decisions in multipotent P19CL6 cells. , 2012, Differentiation; research in biological diversity.

[24]  R. Schwartz,et al.  Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors , 2012, Proceedings of the National Academy of Sciences.

[25]  Yukio Nakamura,et al.  Establishment of Immortalized Human Erythroid Progenitor Cell Lines Able to Produce Enucleated Red Blood Cells , 2012, PloS one.

[26]  Sean P. Palecek,et al.  Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling , 2012, Proceedings of the National Academy of Sciences.

[27]  E. Bikoff,et al.  The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation , 2011, Nature Cell Biology.

[28]  Gordon Keller,et al.  Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. , 2011, Cell stem cell.

[29]  Donald M. Bell,et al.  Tbx6-dependent Sox2 regulation determines neural vs mesodermal fate in axial stem cells , 2010, Nature.

[30]  M. Levine,et al.  Spatio-temporal intersection of Lhx3 and Tbx6 defines the cardiac field through synergistic activation of Mesp. , 2009, Developmental biology.

[31]  V. Papaioannou,et al.  Teasing out T-box targets in early mesoderm. , 2008, Current opinion in genetics & development.

[32]  B. Doble,et al.  The ground state of embryonic stem cell self-renewal , 2008, Nature.

[33]  Gordon Keller,et al.  Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development , 2008, Cell.

[34]  Patrick J. Paddison,et al.  Wnt and TGF-β signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells , 2006, Proceedings of the National Academy of Sciences.

[35]  S. Kattman,et al.  Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. , 2006, Developmental cell.

[36]  Richard A Young,et al.  Chromatin immunoprecipitation and microarray-based analysis of protein location , 2006, Nature Protocols.

[37]  M. Frasch,et al.  The Dorsocross T-box genes are key components of the regulatory network controlling early cardiogenesis in Drosophila , 2005, Development.

[38]  N. Satoh,et al.  The ascidian Mesp gene specifies heart precursor cells , 2004, Development.

[39]  V. Papaioannou,et al.  Critical role for Tbx6 in mesoderm specification in the mouse embryo , 2003, Mechanisms of Development.

[40]  J. Miyazaki,et al.  A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre‐mediated recombination , 2000, FEBS letters.

[41]  J. Miyazaki,et al.  MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube. , 1999, Development.

[42]  Virginia E. Papaioannou,et al.  Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6 , 1998, Nature.

[43]  L. Silver,et al.  Tbx6, a mouse T-Box gene implicated in paraxial mesoderm formation at gastrulation. , 1996, Developmental biology.

[44]  Masaki Ieda,et al.  Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. , 2010, Cell.