Does evening exposure to mobile phone radiation affect subsequent melatonin production?

Purpose: To test whether exposure to the emissions from a digital mobile phone handset prior to sleep alters the secretion of melatonin. Materials and methods: In a double-blind cross-over design, 55 adult volunteers were both actively exposed or sham-exposed (in random order on successive Sunday nights) to mobile phone emissions for 30 min (0.25 W average power). Urine collection occurred immediately prior to retiring to bed and on rising the next morning. Melatonin output was estimated from principal metabolite concentrations (6-sulphatoxymelatonin (aMT6s) via radioimmunoassay), urine volumes and creatinine concentrations. Results: Total melatonin metabolite output (concentration×urine volume) was unchanged between the two exposure conditions (active 14.1±1.1 μg; sham 14.6±1.3 μg). The pre- and post-bedtime outputs considered separately were also not significantly different, although the pre-bedtime value was less for active versus sham exposure. When melatonin metabolite output was estimated from the ratio of aMT6s to creatinine concentrations, the pre-bedtime value was significantly less (p = 0.037) for active compared to sham. Examination of individual responses is suggestive of a small group of ‘responders’. Conclusions: Total nighttime melatonin output is unchanged by mobile phone handset emissions, but there could be an effect on melatonin onset time.

[1]  J. Reif,et al.  Melatonin metabolite excretion among cellular telephone users , 2002, International journal of radiation biology.

[2]  H. A. Sadafi,et al.  Neuropsychological sequelae of 50 Hz magnetic fields , 2001, International journal of radiation biology.

[3]  Fehmi Ozguner,et al.  Prevention of mobile phone induced skin tissue changes by melatonin in rat: an experimental study , 2004, Toxicology and industrial health.

[4]  C. Czeisler,et al.  A mathematical model of diurnal variations in human plasma melatonin levels. , 1997, The American journal of physiology.

[5]  Fehmi Ozguner,et al.  Oxidative Stress‐Mediated Skin Damage in an Experimental Mobile Phone Model Can Be Prevented by Melatonin , 2004, The Journal of dermatology.

[6]  R. de Seze,et al.  GSM radiocellular telephones do not disturb the secretion of antepituitary hormones in humans. , 1998, Bioelectromagnetics.

[7]  A W Wood,et al.  Changes in human plasma melatonin profiles in response to 50 Hz magnetic field exposure , 1998, Journal of pineal research.

[8]  C. Lynch,et al.  Role of the matrixin MMP-2 in multicellular organization of adipocytes cultured in basement membrane components. , 1997, The American journal of physiology.

[9]  Fehmi Ozguner,et al.  No effects of 900 MHz and 1800 MHz electromagnetic field emitted from cellular phone on nocturnal serum melatonin levels in rats , 2005, Toxicology and industrial health.

[10]  R. Reiter,et al.  Do magnetic fields cause increased risk of childhood leukemia via melatonin disruption? , 2005, Bioelectromagnetics.

[11]  J. Reif,et al.  Geomagnetic disturbances are associated with reduced nocturnal excretion of a melatonin metabolite in humans , 1999, Neuroscience Letters.

[12]  H. Tokura,et al.  Effects of the 1900 MHz electromagnetic field emitted from cellular phone on nocturnal melatonin secretion. , 2003, Journal of physiological anthropology and applied human science.

[13]  Con Stough,et al.  The effect of electromagnetic fields emitted by mobile phones on human sleep , 2005, Neuroreport.

[14]  Fehmi Ozguner,et al.  Oxidative damage in the kidney induced by 900-MHz-emitted mobile phone: protection by melatonin. , 2005, Archives of medical research.

[15]  Joachim Röschke,et al.  Effects of Pulsed High-Frequency Electromagnetic Fields on the Neuroendocrine System , 1998, Neuroendocrinology.

[16]  S. Markey,et al.  The correlation between human plasma melatonin levels and urinary 6-hydroxymelatonin excretion. , 1985, Clinica chimica acta; international journal of clinical chemistry.

[17]  J. Redman,et al.  THE CORRELATION BETWEEN SERUM AND SALIVARY MELATONIN CONCENTRATIONS AND URINARY 6‐HYDROXYMELATONIN SULPHATE EXCRETION RATES: TWO NON‐INVASIVE TECHNIQUES FOR MONITORING HUMAN CIRCADIAN RHYTHMICITY , 1987, Clinical endocrinology.

[18]  R. Seze,et al.  Evaluation in humans of the effects of radiocellular telephones on the circadian patterns of melatonin secretion, a chronobiological rhythm marker , 1999, Journal of pineal research.

[19]  F. Waldhauser,et al.  Measurement of urinary melatonin: a useful tool for monitoring serum melatonin after its oral administration. , 2000, The Journal of clinical endocrinology and metabolism.

[20]  S. Steinlechner,et al.  Creatinine is an appropriate reference for urinary sulphatoxymelatonin of laboratory animals and humans , 1997, Journal of pineal research.

[21]  R. Reiter,et al.  Pineal gland “magnetosensitivity” to static magnetic fields is a consequence of induced electric currents (eddy currents) , 1991, Journal of pineal research.

[22]  K Radon,et al.  No effects of pulsed radio frequency electromagnetic fields on melatonin, cortisol, and selected markers of the immune system in man , 2001, Bioelectromagnetics.

[23]  K. Jokela,et al.  ASSESSMENT OF THE MAGNETIC FIELD EXPOSURE DUE TO THE BATTERY CURRENT OF DIGITAL MOBILE PHONES , 2004, Health physics.