3-Oxo-3-(piperidin-1-yl)propanenitrile

In the title compound, C8H12N2O, the piperidine ring exhibits a chair conformation and its least-squares plane (all atoms) makes a dihedral angle of 32.88 (12)° with the propanenitrile unit (r.m.s. deviation = 0.001 Å). In the crystal, molecules are linked by C—H⋯O hydrogen bonds, forming chains along [001].

[1]  E. Tiekink,et al.  1-[(Z)-2-Phenylhydrazin-1-ylidene]-1-(piperidin-1-yl)propan-2-one , 2011, Acta crystallographica. Section E, Structure reports online.

[2]  H. Abdel‐Aziz,et al.  Synthesis and anti-arrhythmic activity of some piperidine-based 1,3-thiazole, 1,3,4-thiadiazole, and 1,3-thiazolo[2,3-c]-1,2,4-triazole derivatives , 2009 .

[3]  Anthony L. Spek,et al.  Structure validation in chemical crystallography , 2009, Acta crystallographica. Section D, Biological crystallography.

[4]  C. A. Roberts,et al.  Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors. , 2008, Bioorganic & medicinal chemistry letters.

[5]  D. Cremer,et al.  General definition of ring puckering coordinates , 1975 .

[6]  C. W. Whitehead,et al.  Synthesis of Cytosines , 1955 .

[7]  G. Sheldrick.  A short history of SHELX. , 2008, Acta crystallographica. Section A, Foundations of crystallography.