Ocular manifestations of hypercupremia associated with multiple myeloma.

Extensive copper infiltration of Descemet membrane of the central cornea and of the anterior and posterior surfaces of the lens is associated with marked hypercupremia related to an abnormal immunoglobulin. Observation of this spectrum of ophthalmic changes in an apparently well middle-aged woman heralded the diagnosis of a unique variety of multiple myeloma.

[1]  K. Hambidge,et al.  Wilson's Disease: Identification of an Abnormal Copper-Binding Protein , 1973, Science.

[2]  G. W. Evans.  Copper homeostasis in the mammalian system. , 1973, Physiological reviews.

[3]  B. J. Stevens,et al.  Menkes' steely-hair (kinky-hair) disease. , 1973, Lancet.

[4]  B. J. Stevens,et al.  Menkes' kinky-hair syndrome. , 1972, Lancet.

[5]  P. Ellis.  Ocular deposition of copper in hypercupremia. , 1969, American journal of ophthalmology.

[6]  J. E. Cairns,et al.  "Sunflower cataract" in Wilson's disease. , 1969, British medical journal.

[7]  D. Rodgerson,et al.  Hypercupremia in a patient with multiple myeloma. , 1967, The Journal of laboratory and clinical medicine.