Biofunctional magnetic nanoparticles for protein separation and pathogen detection.

Recent successful syntheses of monodispersed magnetic nanoparticles have offered a unique opportunity to control and probe biological interactions using magnetic force. This paper highlights a general strategy to generate biofunctional magnetic nanoparticles, illustrates applications for these nanoparticles in protein separation and pathogen detection, and analyzes the high sensitivity and high selectivity achieved by this system.

[1]  Jin-Sil Choi,et al.  In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals. , 2005, Journal of the American Chemical Society.

[2]  Bing Xu,et al.  Multivalent vancomycins and related antibiotics against infectious diseases. , 2005, Current pharmaceutical design.

[3]  Bing Xu,et al.  Synthesis and cellular uptake of porphyrin decorated iron oxide nanoparticles-a potential candidate for bimodal anticancer therapy. , 2005, Chemical communications.

[4]  I. Willner,et al.  Hydrophobic magnetic nanoparticles induce selective bioelectrocatalysis. , 2005, Chemical communications.

[5]  V. Rotello,et al.  Surface PEGylation and Ligand Exchange Chemistry of FePt Nanoparticles for Biological Applications , 2005 .

[6]  Jinwoo Cheon,et al.  Surface modulation of magnetic nanocrystals in the development of highly efficient magnetic resonance probes for intracellular labeling. , 2005, Journal of the American Chemical Society.

[7]  X. Fang,et al.  Twinning‐Mediated Growth of Al2O3 Nanobelts and Their Enhanced Dielectric Responses , 2005 .

[8]  John S. O. Evans,et al.  A synthetic route to size-controlled fcc and fct FePt nanoparticles. , 2005, Journal of the American Chemical Society.

[9]  Hao Zeng,et al.  Bio-functionalization of monodisperse magnetic nanoparticles and their use as biomolecular labels in a magnetic tunnel junction based sensor. , 2005, The journal of physical chemistry. B.

[10]  Ajay Kumar Gupta,et al.  Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. , 2005, Biomaterials.

[11]  Igor L. Medintz,et al.  Quantum dot bioconjugates for imaging, labelling and sensing , 2005, Nature materials.

[12]  Robert L. White,et al.  Towards a magnetic microarray for sensitive diagnostics , 2005 .

[13]  Jinwoo Cheon,et al.  Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging. , 2005, Journal of the American Chemical Society.

[14]  Chad A Mirkin,et al.  Methods for fabricating microarrays of motile bacteria. , 2005, Small.

[15]  Chad A Mirkin,et al.  Nanostructures in biodiagnostics. , 2005, Chemical reviews.

[16]  Marcos Pita,et al.  Functionalization of thioctic acid-capped gold nanoparticles for specific immobilization of histidine-tagged proteins. , 2005, Journal of the American Chemical Society.

[17]  Jinkyu Lee,et al.  Multifunctional nanoparticles possessing a "magnetic motor effect" for drug or gene delivery. , 2005, Angewandte Chemie.

[18]  Yu-Chie Chen,et al.  Affinity capture using vancomycin-bound magnetic nanoparticles for the MALDI-MS analysis of bacteria. , 2005, Analytical chemistry.

[19]  F. Marshall,et al.  In vivo molecular and cellular imaging with quantum dots. , 2005, Current opinion in biotechnology.

[20]  George M Whitesides,et al.  Nanoscience, nanotechnology, and chemistry. , 2005, Small.

[21]  Bing Xu,et al.  Heterodimers of nanoparticles: formation at a liquid-liquid interface and particle-specific surface modification by functional molecules. , 2005, Journal of the American Chemical Society.

[22]  V. Rotello,et al.  Surface recognition of biomacromolecules using nanoparticle receptors. , 2005, Chemical communications.

[23]  Tim Liedl,et al.  On the development of colloidal nanoparticles towards multifunctional structures and their possible use for biological applications. , 2004, Small.

[24]  Xiaosheng Fang,et al.  Temperature‐Controlled Catalytic Growth of ZnS Nanostructures by the Evaporation of ZnS Nanopowders , 2005 .

[25]  Yu-Chie Chen,et al.  Using biofunctionalized nanoparticles to probe pathogenic bacteria. , 2004, Analytical chemistry.

[26]  S. Nie,et al.  Quantum Dot Nanocrystals for In Vivo Molecular and Cellular Imaging¶ , 2004 .

[27]  C. Cao,et al.  A facile synthesis of single-crystal mullite nanobelts. , 2004, Chemical communications.

[28]  Itamar Willner,et al.  Magnetic field effects on cytochrome c-mediated bioelectrocatalytic transformations. , 2004, Journal of the American Chemical Society.

[29]  S. Nie,et al.  In vivo cancer targeting and imaging with semiconductor quantum dots , 2004, Nature Biotechnology.

[30]  Bing Xu,et al.  Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles. , 2004, Journal of the American Chemical Society.

[31]  É. Duguet,et al.  Magnetic nanoparticle design for medical diagnosis and therapy , 2004 .

[32]  Min Gyu Kim,et al.  Characterization of superparamagnetic "core-shell" nanoparticles and monitoring their anisotropic phase transition to ferromagnetic "solid solution" nanoalloys. , 2004, Journal of the American Chemical Society.

[33]  Bing Xu,et al.  Facile one-pot synthesis of bifunctional heterodimers of nanoparticles: a conjugate of quantum dot and magnetic nanoparticles. , 2004, Journal of the American Chemical Society.

[34]  Bing Xu,et al.  Nitrilotriacetic acid-modified magnetic nanoparticles as a general agent to bind histidine-tagged proteins. , 2004, Journal of the American Chemical Society.

[35]  I. Willner,et al.  Magneto-mechanical detection of nucleic acids and telomerase activity in cancer cells. , 2004, Journal of the American Chemical Society.

[36]  Jan Grimm,et al.  Novel Nanosensors for Rapid Analysis of Telomerase Activity , 2004, Cancer Research.

[37]  Hao Zeng,et al.  Monodisperse MFe2O4 (M = Fe, Co, Mn) nanoparticles. , 2004, Journal of the American Chemical Society.

[38]  George Georgiou,et al.  Virus-Based Toolkit for the Directed Synthesis of Magnetic and Semiconducting Nanowires , 2004, Science.

[39]  Ralph Weissleder,et al.  Peroxidase Substrate Nanosensors for MR Imaging , 2004 .

[40]  T. Mihaljevic,et al.  Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping , 2004, Nature Biotechnology.

[41]  Xin Fang,et al.  Temperature-controlled growth of α-Al2O3 nanobelts and nanosheets , 2003 .

[42]  Bing Xu,et al.  Using biofunctional magnetic nanoparticles to capture vancomycin-resistant enterococci and other gram-positive bacteria at ultralow concentration. , 2003, Journal of the American Chemical Society.

[43]  Bing Xu,et al.  Multivalent antibiotics via metal complexes: potent divalent vancomycins against vancomycin-resistant enterococci. , 2003, Journal of medicinal chemistry.

[44]  Bing Xu,et al.  Presenting Vancomycin on Nanoparticles to Enhance Antimicrobial Activities , 2003 .

[45]  Young Woon Kim,et al.  Generalized and facile synthesis of semiconducting metal sulfide nanocrystals. , 2003, Journal of the American Chemical Society.

[46]  Bing Xu,et al.  Self-assembled multivalent vancomycin on cell surfaces against vancomycin-resistant enterococci (VRE). , 2003, Chemical communications.

[47]  Ralph Weissleder,et al.  Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media. , 2003, Journal of the American Chemical Society.

[48]  Bing Xu,et al.  Using biofunctional magnetic nanoparticles to capture gram-negative bacteria at an ultra-low concentration. , 2003, Chemical communications.

[49]  Q. Pankhurst,et al.  TOPICAL REVIEW: Applications of magnetic nanoparticles in biomedicine , 2003 .

[50]  C. Bárcena,et al.  APPLICATIONS OF MAGNETIC NANOPARTICLES IN BIOMEDICINE , 2003 .

[51]  Chemical synthesis of narrowly dispersed SmCo5 nanoparticles , 2003 .

[52]  Taeghwan Hyeon,et al.  Chemical synthesis of magnetic nanoparticles. , 2003, Chemical communications.

[53]  Itamar Willner,et al.  Amplified DNA sensing and immunosensing by the rotation of functional magnetic particles. , 2003, Journal of the American Chemical Society.

[54]  D. Kass,et al.  Novel regulation of cardiac force‐frequency relation by CREM (cAMP response element modulator) , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[55]  Younan Xia,et al.  Shape-Controlled Synthesis of Gold and Silver Nanoparticles , 2002, Science.

[56]  A. R. Bausch,et al.  Colloidosomes: Selectively Permeable Capsules Composed of Colloidal Particles , 2002, Science.

[57]  T. Rajh,et al.  Fe2O3 Nanoparticle Structures Investigated by X-ray Absorption Near-Edge Structure, Surface Modifications, and Model Calculations , 2002 .

[58]  Ralph Weissleder,et al.  Magnetic relaxation switches capable of sensing molecular interactions , 2002, Nature Biotechnology.

[59]  Hao Zeng,et al.  Size-controlled synthesis of magnetite nanoparticles. , 2002, Journal of the American Chemical Society.

[60]  A. Alivisatos,et al.  Synthesis of hcp-Co Nanodisks. , 2002, Journal of the American Chemical Society.

[61]  Ralph Weissleder,et al.  DNA-based magnetic nanoparticle assembly acts as a magnetic relaxation nanoswitch allowing screening of DNA-cleaving agents. , 2002, Journal of the American Chemical Society.

[62]  C. Mirkin,et al.  Array-Based Electrical Detection of DNA with Nanoparticle Probes , 2002, Science.

[63]  S. Nie,et al.  Luminescent quantum dots for multiplexed biological detection and imaging. , 2002, Current opinion in biotechnology.

[64]  J. E. Mattson,et al.  A Group-IV Ferromagnetic Semiconductor: MnxGe1−x , 2002, Science.

[65]  Taeghwan Hyeon,et al.  Synthesis of highly crystalline and monodisperse maghemite nanocrystallites without a size-selection process. , 2001, Journal of the American Chemical Society.

[66]  J. Cheon,et al.  Synthesis of "solid solution" and "core-shell" type cobalt--platinum magnetic nanoparticles via transmetalation reactions. , 2001, Journal of the American Chemical Society.

[67]  Nicholas A. Kotov,et al.  Albumin−CdTe Nanoparticle Bioconjugates: Preparation, Structure, and Interunit Energy Transfer with Antenna Effect , 2001 .

[68]  Zhong Lin Wang,et al.  Nanobelts of Semiconducting Oxides , 2001, Science.

[69]  J. Matthew Mauro,et al.  Self-Assembly of CdSe−ZnS Quantum Dot Bioconjugates Using an Engineered Recombinant Protein , 2000 .

[70]  C. Mirkin,et al.  Scanometric DNA array detection with nanoparticle probes. , 2000, Science.

[71]  T. Hyeon,et al.  Synthesis and Magnetic Studies of Uniform Iron Nanorods and Nanospheres , 2000 .

[72]  Younan Xia,et al.  Monodispersed Colloidal Spheres: Old Materials with New Applications , 2000 .

[73]  Sun,et al.  Monodisperse FePt nanoparticles and ferromagnetic FePt nanocrystal superlattices , 2000, Science.

[74]  Weidong Yang,et al.  Shape control of CdSe nanocrystals , 2000, Nature.

[75]  Moungi G. Bawendi,et al.  Organometallic Synthesis and Spectroscopic Characterization of Manganese-Doped CdSe Nanocrystals , 2000 .

[76]  A. Moser,et al.  Thermal effect limits in ultrahigh-density magnetic recording , 1999 .

[77]  S. Nie,et al.  Quantum dot bioconjugates for ultrasensitive nonisotopic detection. , 1998, Science.

[78]  D. Balding,et al.  HLA Sequence Polymorphism and the Origin of Humans , 2006 .

[79]  Chad A. Mirkin,et al.  One-Pot Colorimetric Differentiation of Polynucleotides with Single Base Imperfections Using Gold Nanoparticle Probes , 1998 .

[80]  A. Campion,et al.  Surface-enhanced Raman scattering , 1998 .

[81]  J. Storhoff,et al.  Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles. , 1997, Science.

[82]  Steven R. Emory,et al.  Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering , 1997, Science.

[83]  J. Griffin,et al.  Novel Vancomycin Dimers with Activity against Vancomycin-Resistant Enterococci , 1996 .

[84]  M. Nirmal,et al.  Fluorescence intermittency in single cadmium selenide nanocrystals , 1996, Nature.

[85]  J. Storhoff,et al.  A DNA-based method for rationally assembling nanoparticles into macroscopic materials , 1996, Nature.

[86]  A. Alivisatos.  Semiconductor Clusters, Nanocrystals, and Quantum Dots , 1996, Science.

[87]  Cherie R. Kagan,et al.  Self-Organization of CdSe Nanocrystallites into Three-Dimensional Quantum Dot Superlattices , 1995, Science.

[88]  R N Zare,et al.  Probing individual molecules with confocal fluorescence microscopy. , 1994, Science.

[89]  M. Bawendi,et al.  Synthesis and characterization of nearly monodisperse CdE (E = sulfur, selenium, tellurium) semiconductor nanocrystallites , 1993 .