Novel insights into the role of cardiotrophin-1 in cardiovascular diseases.

[1]  Juan Liu,et al.  Simvastatin prevents cardiac hypertrophy in vitro and in vivo via JAK/STAT pathway. , 2008, Life sciences.

[2]  Baofeng Yang,et al.  Novel functional role of heat shock protein 90 in ATP-sensitive K+ channel-mediated hypoxic preconditioning. , 2008, Cardiovascular research.

[3]  C. Hengstenberg,et al.  Head-to-head comparison of BNP and IL-6 as markers of clinical and experimental heart failure: Superiority of BNP. , 2007, Cytokine.

[4]  J. Castellano,et al.  Association of Increased Plasma Cardiotrophin-1 With Inappropriate Left Ventricular Mass in Essential Hypertension , 2007, Hypertension.

[5]  M. Horie,et al.  Plasma level of cardiotrophin‐1 as a prognostic predictor in patients with chronic heart failure , 2007, European journal of heart failure.

[6]  C. Pemberton Hypertension, cardiotrophin-1 and gp130: three points to heart failure? , 2007, Journal of hypertension.

[7]  J. Díez,et al.  Mechanisms of Cardiac Fibrosis in Hypertension , 2007, Journal of clinical hypertension.

[8]  M. He,et al.  Heat shock protein 70 gene transfection protects rat myocardium cell against anoxia-reoxygeneration injury. , 2007, Chinese medical journal.

[9]  J. Prieto,et al.  Cardiotrophin‐1 is an essential factor in the natural defense of the liver against apoptosis , 2007, Hepatology.

[10]  K. Sliwa,et al.  A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy , 2007, Cell.

[11]  P. Collinson,et al.  Biomarkers of cardiovascular damage and dysfunction--an overview. , 2007, Heart, lung & circulation.

[12]  R. Vasan,et al.  Biomarkers of Cardiovascular Disease: Molecular Basis and Practical Considerations , 2006, Circulation.

[13]  Paul M Ridker,et al.  C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients. , 2006, Journal of the American College of Cardiology.

[14]  M. Sabatine,et al.  Inflammatory Biomarkers in Acute Coronary Syndromes: Part IV: Matrix Metalloproteinases and Biomarkers of Platelet Activation , 2006, Circulation.

[15]  B. Llamas,et al.  A Genetic Locus Accentuates the Effect of Volume Overload on Adverse Left Ventricular Remodeling in Male and Female Rats , 2006, Hypertension.

[16]  Bing Lang,et al.  Simvastatin attenuates hypertrophic responses induced by cardiotrophin-1 via JAK–STAT pathway in cultured cardiomyocytes , 2006, Molecular and Cellular Biochemistry.

[17]  Arantxa González,et al.  Usefulness of plasma cardiotrophin-1 in assessment of left ventricular hypertrophy regression in hypertensive patients , 2005, Journal of hypertension.

[18]  V. Cameron,et al.  Plasma cardiotrophin-1 is elevated in human hypertension and stimulated by ventricular stretch. , 2005, Cardiovascular research.

[19]  M. Fortuño,et al.  Characterization of the protective effects of cardiotrophin-1 against non-ischemic death stimuli in adult cardiomyocytes. , 2005, Cytokine.

[20]  F. Muenzel,et al.  Chronic cardiotrophin-1 stimulation impairs contractile function in reconstituted heart tissue. , 2005, American journal of physiology. Endocrinology and metabolism.

[21]  J. Lasarte,et al.  Is plasma cardiotrophin-1 a marker of hypertensive heart disease? , 2005, Journal of hypertension.

[22]  K. Nakao,et al.  Hypertrophic responses to cardiotrophin-1 are not mediated by STAT3, but via a MEK5-ERK5 pathway in cultured cardiomyocytes. , 2005, Journal of molecular and cellular cardiology.

[23]  J. Randon,et al.  Increased expression of IL-6 and LIF in the hypertrophied left ventricle of TGR(mRen2)27 and SHR rats , 2005, Molecular and Cellular Biochemistry.

[24]  J. Stephens,et al.  Effects of Cardiotrophin on Adipocytes* , 2004, Journal of Biological Chemistry.

[25]  Michael D. Schneider,et al.  Signal Transducer and Activator of Transcription 3 Is Required for Myocardial Capillary Growth, Control of Interstitial Matrix Deposition, and Heart Protection From Ischemic Injury , 2004, Circulation research.

[26]  T. Bai,et al.  Cardiotrophin-1 alters airway smooth muscle structure and mechanical properties in airway explants. , 2004, American journal of physiology. Lung cellular and molecular physiology.

[27]  Stephen C. Jones,et al.  Cardiotrophin-1: Expression in experimental myocardial infarction and potential role in post-MI wound healing , 2003, Molecular and Cellular Biochemistry.

[28]  I. Dixon,et al.  Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways. , 2003, Cardiovascular research.

[29]  R. Oppenheim,et al.  Cardiotrophin-Like Cytokine/Cytokine-Like Factor 1 is an Essential Trophic Factor for Lumbar and Facial Motoneurons In Vivo , 2003, The Journal of Neuroscience.

[30]  A. Luchner,et al.  Ventricular cardiotrophin-1 activation precedes BNP in experimental heart failure , 2003, Peptides.

[31]  A. Clerico The Increasing Impact of Laboratory Medicine on Clinical Cardiology , 2003, Clinical chemistry and laboratory medicine.

[32]  K. Yamauchi-Takihara Gp130-mediated pathway and left ventricular remodeling. , 2002, Journal of cardiac failure.

[33]  M. Weyand,et al.  Augmented Expression of Cardiotrophin-1 in Failing Human Hearts Is Accompanied by Diminished Glycoprotein 130 Receptor Protein Abundance , 2002, Circulation.

[34]  D. Latchman,et al.  Cardiotrophin-1 (CT-1) can protect the adult heart from injury when added both prior to ischaemia and at reperfusion. , 2002, Cardiovascular research.

[35]  D. Latchman,et al.  Cardiotrophin-1 and urocortin cause protection by the same pathway and hypertrophy via distinct pathways in cardiac myocytes. , 2002, Cytokine.

[36]  J. Burnett,et al.  Cardiotrophin-1 Stimulation of Cardiac Fibroblast Growth: Roles for Glycoprotein 130/Leukemia Inhibitory Factor Receptor and the Endothelin Type A Receptor , 2002, Circulation research.

[37]  I. Squire,et al.  Plasma cardiotrophin-1 following acute myocardial infarction: relationship with left ventricular systolic dysfunction , 2002 .

[38]  Leong L Ng,et al.  Plasma cardiotrophin-1 following acute myocardial infarction: relationship with left ventricular systolic dysfunction. , 2002, Clinical science.

[39]  K. Nakao,et al.  Relationship between plasma level of cardiotrophin-1 and left ventricular mass index in patients with dilated cardiomyopathy. , 2001, Journal of the American College of Cardiology.

[40]  D. Latchman,et al.  CT-1 mediated cardioprotection against ischaemic re-oxygenation injury is mediated by PI3 kinase, Akt and MEK1/2 pathways. , 2001, Cytokine.

[41]  D. Latchman Heat shock proteins and cardiac protection. , 2001, Cardiovascular research.

[42]  Y. Fujio,et al.  Activation of Signal Transducer and Activator of Transcription 3 Protects Cardiomyocytes from Hypoxia/Reoxygenation-Induced Oxidative Stress Through the Upregulation of Manganese Superoxide Dismutase , 2001, Circulation.

[43]  D. Yellon,et al.  Cardiotrophin-1 can protect cardiac myocytes from injury when added both prior to simulated ischaemia and at reoxygenation. , 2001, Cardiovascular research.

[44]  R. Oppenheim,et al.  Cardiotrophin-1, a Muscle-Derived Cytokine, Is Required for the Survival of Subpopulations of Developing Motoneurons , 2001, The Journal of Neuroscience.

[45]  Y. Fujio,et al.  Glycoprotein 130 Regulates Cardiac Myocyte Survival in Doxorubicin-Induced Apoptosis Through Phosphatidylinositol 3-Kinase/Akt Phosphorylation and Bcl-xL/Caspase-3 Interaction , 2001, Circulation.

[46]  D. Barnett,et al.  Plasma N‐terminal pro BNP and cardiotrophin‐1 are elevated in aortic stenosis , 2001, European journal of heart failure.

[47]  I. Kishimoto,et al.  The heart is a source of circulating cardiotrophin-1 in humans. , 2000, Biochemical and biophysical research communications.

[48]  I. Squire,et al.  The effect of valvular regurgitation on plasma Cardiotrophin‐1 in patients with normal left ventricular systolic function , 2000, European journal of heart failure.

[49]  I. Squire,et al.  Plasma N terminal pro-brain natriuretic peptide and cardiotrophin 1 are raised in unstable angina , 2000, Heart.

[50]  T. Kishimoto,et al.  Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction. , 2000, Cardiovascular research.

[51]  I. Kishimoto,et al.  Cardiotrophin-1 phosphorylates akt and BAD, and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes. , 2000, Journal of molecular and cellular cardiology.

[52]  A. M. Richards Cardiotrophin-1: a new cardiac marker? , 2000, Clinical science.

[53]  L. Ng,et al.  Elevated circulating cardiotrophin-1 in heart failure: relationship with parameters of left ventricular systolic dysfunction. , 2000, Clinical science.

[54]  I. Masuda,et al.  Effects of cardiotrophin-1 on hemodynamics and endocrine function of the heart. , 2000, American journal of physiology. Heart and circulatory physiology.

[55]  M. Okabe,et al.  Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[56]  M. Redfield,et al.  Augmented cardiac cardiotrophin-1 in experimental congestive heart failure. , 2000, Circulation.

[57]  D. Latchman Cardiotrophin-1: a novel cytokine and its effects in the heart and other tissues. , 2000, Pharmacology & therapeutics.

[58]  D. Latchman Cardiotrophin‐1 (CT‐1): a novel hypertrophic and cardioprotective agent , 1999, International journal of experimental pathology.

[59]  P. Heinrich,et al.  Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. , 1998, The Biochemical journal.

[60]  Y. Fujio,et al.  Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes. , 1998, Circulation.

[61]  B. Brar,et al.  Cardiotrophin-1 induces heat shock protein accumulation in cultured cardiac cells and protects them from stressful stimuli. , 1998, Journal of molecular and cellular cardiology.

[62]  W. Wood,et al.  Effects of cardiotrophin-1 on haemodynamics and cardiac function in conscious rats. , 1998, Cytokine.

[63]  K. Chien,et al.  Cardiotrophin 1 (CT-1) Inhibition of Cardiac Myocyte Apoptosis via a Mitogen-activated Protein Kinase-dependent Pathway , 1997, The Journal of Biological Chemistry.

[64]  H. Itoh,et al.  Role of cardiac nonmyocytes in cyclic mechanical stretch-induced myocyte hypertrophy. , 1997, Heart and vessels.

[65]  W. Wood,et al.  In vivo effects of cardiotrophin-1. , 1996, Cytokine.

[66]  J. Heath,et al.  Cardiotrophin-1 Activates a Distinct Form of Cardiac Muscle Cell Hypertrophy , 1996, The Journal of Biological Chemistry.

[67]  W. Wood,et al.  Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization. , 1996, Cytokine.

[68]  K. Chien,et al.  Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival. , 1996, Development.

[69]  S. Akira,et al.  Interleukin-6 family of cytokines and gp130. , 1995, Blood.

[70]  W. Wood,et al.  Cardiotrophin-1 , 1995, The Journal of Biological Chemistry.

[71]  K. Chien,et al.  Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[72]  S. Akira,et al.  Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway , 1994, Cell.

[73]  S. Akira,et al.  Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[74]  P. Heinrich,et al.  Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level , 1993, Molecular and cellular biology.

[75]  M. Hibi,et al.  Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo. , 1992, Journal of immunology.