Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology

[1]  D. Lazarević,et al.  Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress , 2022, Nature Immunology.

[2]  K. Yan,et al.  Haploinsufficiency of PSMD12 Causes Proteasome Dysfunction and Subclinical Autoinflammation , 2022, Arthritis & rheumatology.

[3]  F. Granucci,et al.  Inhibition of transcription factor NFAT activity in activated platelets enhances their aggregation and exacerbates gram-negative bacterial septicemia. , 2021, Immunity.

[4]  B. Walzog,et al.  Distinct transcription factor networks control neutrophil-driven inflammation , 2021, Nature Immunology.

[5]  G. Natoli,et al.  Induction of OCT2 contributes to regulate the gene expression program in human neutrophils activated via TLR8. , 2021, Cell reports.

[6]  A. Luft,et al.  Neutrophils Obstructing Brain Capillaries Are a Major Cause of No-Reflow in Ischemic Stroke. , 2020, Cell reports.

[7]  P. Foster,et al.  A Critical Role for the CXCL3/CXCL5/CXCR2 Neutrophilic Chemotactic Axis in the Regulation of Type 2 Responses in a Model of Rhinoviral-Induced Asthma Exacerbation , 2020, The Journal of Immunology.

[8]  I. Amit,et al.  Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19 , 2020, Cell.

[9]  Alexander Sczyrba,et al.  Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment , 2020, Cell.

[10]  Irving L. Weissman,et al.  A single-cell transcriptomic atlas characterizes ageing tissues in the mouse , 2020, Nature.

[11]  L. Bystrykh,et al.  A comprehensive transcriptome signature of murine hematopoietic stem cell aging , 2020, bioRxiv.

[12]  Robert A. Campbell,et al.  Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome , 2020, Blood.

[13]  F. Ginhoux,et al.  Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor. , 2020, Immunity.

[14]  T. Cheng,et al.  Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection , 2020, Nature Immunology.

[15]  J. Teruya-Feldstein,et al.  Hypersegmented granulocytes and COVID-19 infection , 2020, Blood.

[16]  D. Hoffmann,et al.  Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19 , 2020, Frontiers in Immunology.

[17]  B. Becher,et al.  Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes , 2020, Cell.

[18]  C. Iadecola,et al.  Immune responses to stroke: mechanisms, modulation, and therapeutic potential. , 2020, The Journal of clinical investigation.

[19]  M. Filippi,et al.  Leukocyte Counts and Ratios Are Predictive of Stroke Outcome and Hemorrhagic Complications Independently of Infections , 2020, Frontiers in Neurology.

[20]  Ronald R. Coifman,et al.  Visualizing structure and transitions in high-dimensional biological data , 2019, Nature Biotechnology.

[21]  D. Attwell,et al.  Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes , 2019, Science.

[22]  Paul J. Hoffman,et al.  Comprehensive Integration of Single-Cell Data , 2018, Cell.

[23]  Virginia Savova,et al.  Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species. , 2019, Immunity.

[24]  L. Ng,et al.  Heterogeneity of neutrophils , 2019, Nature Reviews Immunology.

[25]  G. Lenz,et al.  Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils , 2019, Nature Immunology.

[26]  B. Chong,et al.  Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia , 2019, Nature Communications.

[27]  C. Weber,et al.  A Neutrophil Timer Coordinates Immune Defense and Vascular Protection , 2019, Immunity.

[28]  Myriam Peyrounette,et al.  Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models , 2018, Nature Neuroscience.

[29]  Lai Guan Ng,et al.  Dimensionality reduction for visualizing single-cell data using UMAP , 2018, Nature Biotechnology.

[30]  The Gene Ontology Consortium,et al.  The Gene Ontology Resource: 20 years and still GOing strong , 2018, Nucleic Acids Res..

[31]  Leland McInnes,et al.  UMAP: Uniform Manifold Approximation and Projection , 2018, J. Open Source Softw..

[32]  A. Valencia,et al.  Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils , 2018, Cell reports.

[33]  A. Annoni,et al.  Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens , 2018, Nature Communications.

[34]  I. Amit,et al.  Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis , 2018, Nature Cell Biology.

[35]  P. Frenette,et al.  Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche , 2018, Nature Medicine.

[36]  F. Ginhoux,et al.  Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions , 2018, Immunity.

[37]  A. Arrick,et al.  Institutional Animal Care and Use Committee (IACUC) , 2018 .

[38]  Leland McInnes,et al.  UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction , 2018, ArXiv.

[39]  M. Sarazin,et al.  Neutrophil hyperactivation correlates with Alzheimer's disease progression , 2018, Annals of neurology.

[40]  G. Comi,et al.  Neural precursor cell–secreted TGF-&bgr;2 redirects inflammatory monocyte-derived cells in CNS autoimmunity , 2017, The Journal of clinical investigation.

[41]  Hannah A. Pliner,et al.  Reversed graph embedding resolves complex single-cell trajectories , 2017, Nature Methods.

[42]  S. Gabriel,et al.  Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease , 2017, The New England journal of medicine.

[43]  J. Aerts,et al.  SCENIC: Single-cell regulatory network inference and clustering , 2017, Nature Methods.

[44]  Yves Dauvilliers,et al.  High-dimensional single-cell analysis reveals the immune signature of narcolepsy , 2016, The Journal of experimental medicine.

[45]  D. Centonze,et al.  Neural Stem Cell Transplantation Induces Stroke Recovery by Upregulating Glutamate Transporter GLT-1 in Astrocytes , 2016, The Journal of Neuroscience.

[46]  J. Cowland,et al.  Granulopoiesis and granules of human neutrophils , 2016, Immunological reviews.

[47]  H. Geiger,et al.  Aging, Clonality, and Rejuvenation of Hematopoietic Stem Cells. , 2016, Trends in molecular medicine.

[48]  Adeeb H. Rahman,et al.  Heparin reduces nonspecific eosinophil staining artifacts in mass cytometry experiments , 2016, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[49]  H. Maecker,et al.  Platinum‐conjugated antibodies for application in mass cytometry , 2016, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[50]  C. Harris,et al.  Flow cytometric assay for direct quantification of neutrophil extracellular traps in blood samples , 2015, American journal of hematology.

[51]  J. Faith,et al.  Neutrophil ageing is regulated by the microbiome , 2015, Nature.

[52]  Piet Demeester,et al.  FlowSOM: Using self‐organizing maps for visualization and interpretation of cytometry data , 2015, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[53]  M. Moskowitz,et al.  Ischemic Stroke Activates Hematopoietic Bone Marrow Stem Cells , 2015, Circulation research.

[54]  Eli R. Zunder,et al.  Palladium-based mass tag cell barcoding with a doublet-filtering scheme and single-cell deconvolution algorithm , 2015, Nature Protocols.

[55]  M. McCarthy,et al.  Age-related clonal hematopoiesis associated with adverse outcomes. , 2014, The New England journal of medicine.

[56]  A. Adewoyin,et al.  PERIPHERAL BLOOD FILM - A REVIEW , 2014, Annals of Ibadan postgraduate medicine.

[57]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[58]  C. Weber,et al.  Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance , 2013, Cell.

[59]  Sean C. Bendall,et al.  Normalization of mass cytometry data with bead standards , 2013, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[60]  S. Wong,et al.  SNX3 recruits to phagosomes and negatively regulates phagocytosis in dendritic cells , 2013, Immunology.

[61]  L. Koenderman,et al.  Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences , 2013, Cellular and Molecular Life Sciences.

[62]  Justin Guinney,et al.  GSVA: gene set variation analysis for microarray and RNA-Seq data , 2013, BMC Bioinformatics.

[63]  D. Centonze,et al.  Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. , 2012, Brain : a journal of neurology.

[64]  C. Di Serio,et al.  Brain conditioning is instrumental for successful microglia reconstitution following hematopoietic stem cell transplantation , 2012, Proceedings of the National Academy of Sciences.

[65]  Sean C. Bendall,et al.  Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum , 2011, Science.

[66]  W. Huber,et al.  which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets , 2011 .

[67]  Turgay Dalkara,et al.  Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery , 2009, Nature Medicine.

[68]  G. Comi,et al.  Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. , 2009, Brain : a journal of neurology.

[69]  F. Burzotta,et al.  Myocardial no-reflow in humans. , 2009, Journal of the American College of Cardiology.

[70]  Christian Gerloff,et al.  Temporal and spatial dynamics of cerebral immune cell accumulation in stroke. , 2009, Stroke.

[71]  A. Persson,et al.  The tetraspanin CD63 is involved in granule targeting of neutrophil elastase. , 2008, Blood.

[72]  F. Peale,et al.  Bv8 regulates myeloid-cell-dependent tumour angiogenesis , 2007, Nature.

[73]  Hong Sun,et al.  Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPepsilon gene. , 2007, Blood.

[74]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[75]  B. Bain,et al.  Diagnosis from the blood smear. , 2005, The New England journal of medicine.

[76]  I. Weissman,et al.  Cell intrinsic alterations underlie hematopoietic stem cell aging. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[77]  P. Allen,et al.  Inflammatory arthritis requires Foxo3a to prevent Fas ligand–induced neutrophil apoptosis , 2005, Nature Medicine.

[78]  J. Cowland,et al.  The in vivo profile of transcription factors during neutrophil differentiation in human bone marrow. , 2003, Blood.

[79]  V. Feigin,et al.  Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century , 2003, The Lancet Neurology.

[80]  B. Houwen Blood film preparation and staining procedures. , 2002, Clinics in laboratory medicine.

[81]  J. Vinten-johansen,et al.  The role of neutrophils in myocardial ischemia-reperfusion injury. , 1999, Cardiovascular research.

[82]  D. Tenen,et al.  Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[83]  P. Bonini,et al.  Effect of clot-detection methods and reagents on activated partial thromboplastin time (APTT). Implications in heparin monitoring by APTT. , 1990, American journal of clinical pathology.

[84]  A. D’Angelo,et al.  Evaluation of Coagulometric Assays in the Assessment of Protein C Anticoagulant Activity; Variable Sensitivity of Commercial APTT Reagents to the Cofactor Effect of Protein S , 1989, Thrombosis and Haemostasis.

[85]  M. Greter,et al.  Isolation of leukocytes from mouse central nervous system. , 2014, Methods in molecular biology.

[86]  H. Hemker,et al.  Data management in thrombin generation. , 2013, Thrombosis research.