Meta-analysis identifies seven susceptibility loci involved in the atopic march

[1]  Michael Q. Zhang,et al.  Integrative analysis of 111 reference human epigenomes , 2015, Nature.

[2]  Judith A. Blake,et al.  The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease , 2014, Nucleic Acids Res..

[3]  P. Aubert,et al.  Food allergy enhances allergic asthma in mice , 2014, Respiratory Research.

[4]  K. Wanner,et al.  Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2. , 2014, Journal of medicinal chemistry.

[5]  D. Leung,et al.  Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches. , 2014, The Journal of allergy and clinical immunology.

[6]  Takashi Sasaki,et al.  Application of moisturizer to neonates prevents development of atopic dermatitis. , 2014, The Journal of allergy and clinical immunology.

[7]  H. Williams,et al.  Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention , 2014, The Journal of allergy and clinical immunology.

[8]  Iain Buchan,et al.  Developmental Profiles of Eczema , Wheeze , and Rhinitis : Two Population-Based Birth Cohort Studies , 2014 .

[9]  Mei Li Current evidence of epidermal barrier dysfunction and thymic stromal lymphopoietin in the atopic march , 2014, European Respiratory Review.

[10]  Manuel A. R. Ferreira,et al.  Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. , 2014, The Journal of allergy and clinical immunology.

[11]  M. Kubo,et al.  Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis. , 2014, The Journal of allergy and clinical immunology.

[12]  F. Nestle,et al.  Mechanisms regulating skin immunity and inflammation , 2014, Nature Reviews Immunology.

[13]  Kristina M. Giorda,et al.  TMTC1 and TMTC2 Are Novel Endoplasmic Reticulum Tetratricopeptide Repeat-containing Adapter Proteins Involved in Calcium Homeostasis* , 2014, The Journal of Biological Chemistry.

[14]  Cesare Furlanello,et al.  A promoter-level mammalian expression atlas , 2015 .

[15]  M. Wickman,et al.  Infantile eczema: Prognosis and risk of asthma and rhinitis in preadolescence. , 2014, The Journal of allergy and clinical immunology.

[16]  J. Silverberg,et al.  Allergic disease is associated with epilepsy in childhood: a US population‐based study , 2014, Allergy.

[17]  A. Lowe,et al.  Atopic dermatitis and the atopic march revisited , 2014, Allergy.

[18]  Peggy Hall,et al.  The NHGRI GWAS Catalog, a curated resource of SNP-trait associations , 2013, Nucleic Acids Res..

[19]  Egidio Barbi,et al.  IgE-mediated food allergy in children , 2013, The Lancet.

[20]  G. Uhl,et al.  Involvement of the Neutral Amino Acid Transporter SLC6A15 and Leucine in Obesity-Related Phenotypes , 2013, PloS one.

[21]  Pedro G. Ferreira,et al.  Transcriptome and genome sequencing uncovers functional variation in humans , 2013, Nature.

[22]  Chuong B. Do,et al.  A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci , 2013, Nature Genetics.

[23]  L. Kemény,et al.  Toll-like receptors link atopic march to the hygiene hypothesis. , 2013, The Journal of investigative dermatology.

[24]  M. Wickman,et al.  Eczema severity in preadolescent children and its relation to sex, filaggrin mutations, asthma, rhinitis, aggravating factors and topical treatment: a report from the BAMSE birth cohort , 2013, The British journal of dermatology.

[25]  W. Maier,et al.  A variant of the neuronal amino acid transporter SLC6A15 is associated with ACTH and cortisol responses and cognitive performance in unipolar depression. , 2013, The international journal of neuropsychopharmacology.

[26]  P. Romundstad,et al.  Early eczema and the risk of childhood asthma: a prospective, population-based study , 2012, BMC Pediatrics.

[27]  Å. Svensson,et al.  Eczema in early childhood is strongly associated with the development of asthma and rhinitis in a prospective cohort , 2012, BMC Dermatology.

[28]  ENCODEConsortium,et al.  An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.

[29]  H. Mizuno,et al.  Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice. , 2012, The Journal of allergy and clinical immunology.

[30]  Christian Gieger,et al.  META-ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIES IDENTIFIES THREE NEW RISK LOCI FOR ATOPIC DERMATITIS , 2011, Nature Genetics.

[31]  David J Balding,et al.  A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. , 2011, The Journal of allergy and clinical immunology.

[32]  S. Lau,et al.  The eczema risk variant on chromosome 11q13 (rs7927894) in the population-based ALSPAC cohort: a novel susceptibility factor for asthma and hay fever. , 2011, Human molecular genetics.

[33]  G. Giles,et al.  Childhood eczema and rhinitis predict atopic but not nonatopic adult asthma: a prospective cohort study over 4 decades. , 2011, The Journal of allergy and clinical immunology.

[34]  A. Hofman,et al.  The Neuronal Transporter Gene SLC6A15 Confers Risk to Major Depression , 2011, Neuron.

[35]  G. Abecasis,et al.  MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes , 2010, Genetic epidemiology.

[36]  C. Brightling,et al.  Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma. , 2010, The Journal of allergy and clinical immunology.

[37]  Florence Demenais,et al.  A large-scale, consortium-based genomewide association study of asthma. , 2010, The New England journal of medicine.

[38]  J. Spergel Epidemiology of atopic dermatitis and atopic march in children. , 2010, Immunology and allergy clinics of North America.

[39]  J. Spergel,et al.  From atopic dermatitis to asthma: the atopic march. , 2010, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[40]  Yun Li,et al.  METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..

[41]  Vandana Sundaram,et al.  Diagnosing and managing common food allergies: a systematic review. , 2010, JAMA.

[42]  D. Postma,et al.  A sequence variant on 17q21 is associated with age at onset and severity of asthma , 2010, European Journal of Human Genetics.

[43]  S. Willich,et al.  The multinational birth cohort of EuroPrevall: background, aims and methods , 2010, Allergy.

[44]  D. Postma,et al.  Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure , 2009, Allergy.

[45]  A. Sheikh,et al.  Establishing the sequential progression of multiple allergic diagnoses in a UK birth cohort using the General Practice Research Database , 2009, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[46]  P. Donnelly,et al.  A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies , 2009, PLoS genetics.

[47]  S. Heath,et al.  A common variant on chromosome 11q13 is associated with atopic dermatitis , 2009, Nature Genetics.

[48]  T. Tsumoto,et al.  Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility. , 2009, Human molecular genetics.

[49]  Cecilia Kim,et al.  Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood. , 2009, American journal of respiratory and critical care medicine.

[50]  Andrew D. Johnson,et al.  SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap , 2008, Bioinform..

[51]  M. T. Medina,et al.  Novel mutations in Myoclonin1/EFHC1 in sporadic and familial juvenile myoclonic epilepsy , 2008, Neurology.

[52]  M. Pembrey,et al.  The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study. , 2008, The Journal of allergy and clinical immunology.

[53]  D. Margolis,et al.  The prevalence of atopic triad in children with physician-confirmed atopic dermatitis. , 2008, Journal of the American Academy of Dermatology.

[54]  Colin Summers,et al.  The prevalence of food allergy: a meta-analysis. , 2007, The Journal of allergy and clinical immunology.

[55]  P. Striano,et al.  Mutational Analysis of EFHC1 Gene in Italian Families with Juvenile Myoclonic Epilepsy , 2007, Epilepsia.

[56]  G. Marks,et al.  Early predictors for developing allergic disease and asthma: examining separate steps in the ‘allergic march’ , 2007, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[57]  H. Klip,et al.  Risk of developing asthma in young children with atopic eczema: a systematic review. , 2007, The Journal of allergy and clinical immunology.

[58]  Gonçalo R. Abecasis,et al.  Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma , 2007, Nature.

[59]  Colin N A Palmer,et al.  Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema , 2007, Nature Genetics.

[60]  C Baumgartner,et al.  Idiopathic generalized epilepsy phenotypes associated with different EFHC1 mutations , 2006, Neurology.

[61]  D. Reich,et al.  Population Structure and Eigenanalysis , 2006, PLoS genetics.

[62]  E. Baldi,et al.  Long-term follow-up of atopic dermatitis: retrospective analysis of related risk factors and association with concomitant allergic diseases. , 2006, Journal of the American Academy of Dermatology.

[63]  T. Keil,et al.  Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march. , 2006, The Journal of allergy and clinical immunology.

[64]  P. Hedera,et al.  Mutations in the GABRA1 and EFHC1 genes are rare in familial juvenile myoclonic epilepsy , 2006, Epilepsy Research.

[65]  Colin N A Palmer,et al.  Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis , 2006, Nature Genetics.

[66]  M. Hirono,et al.  The mouse ortholog of EFHC1 implicated in juvenile myoclonic epilepsy is an axonemal protein widely conserved among organisms with motile cilia and flagella , 2005, FEBS letters.

[67]  M. T. Medina,et al.  Mutations in EFHC1 cause juvenile myoclonic epilepsy , 2004, Nature Genetics.

[68]  S. Gabriel,et al.  Assessing the impact of population stratification on genetic association studies , 2004, Nature Genetics.

[69]  R L Williams,et al.  A Note on Robust Variance Estimation for Cluster‐Correlated Data , 2000, Biometrics.

[70]  R. Geha,et al.  Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. , 1998, The Journal of clinical investigation.

[71]  Joshua Lederberg,et al.  Children's Hospital of Philadelphia. , 1975, The Australasian nurses journal.

[72]  Albert,et al.  THE CHILDREN'S HOSPITAL OF PHILADELPHIA , 1955 .