Visualizing and enhancing axial resolution in nonconfocal adaptive optics ophthalmoscopy

We propose a study to better understand the impact of dynamic ocular aberrations in the axial resolution of nonconfocal adaptive optics (AO) ophthalmoscopes via a simulation of the 3D PSF in the retina for various AO-loop rates. We then use Optical Incoherence Tomography (OIT), a method enabling the generation of tomographic retinal cross-sections in incoherent imaging systems, to evaluate the benefits of a fast AO-loop rate on axial resolution and consequently on AO-corrected retinal image quality. We used the PARIS AO flood- illumination ophthalmoscope (FIO) for this study, where retinal images from different focal planes at an AO-loop rate of 10 Hz and 50 Hz were acquired.

[1]  Jennifer J. Hunter,et al.  Vision science and adaptive optics, the state of the field , 2017, Vision Research.

[2]  Jennifer J. Hunter,et al.  Imaging individual neurons in the retinal ganglion cell layer of the living eye , 2017, Proceedings of the National Academy of Sciences.

[3]  Stephen A. Burns,et al.  Infrared imaging of sub-retinal structures in the human ocular fundus , 1996, Vision Research.

[4]  A. Dubra,et al.  In vivo dark-field imaging of the retinal pigment epithelium cell mosaic. , 2013, Biomedical optics express.

[5]  T. Dryja,et al.  Understanding the etiology of Stargardt's disease. , 2002, Ophthalmology clinics of North America.

[6]  Austin Roorda,et al.  Adaptive optics retinal imaging: emerging clinical applications. , 2010, Optometry and vision science : official publication of the American Academy of Optometry.

[7]  Deeba Husain,et al.  Mechanisms of age-related macular degeneration. , 2002, Ophthalmology clinics of North America.

[8]  Omer P. Kocaoglu,et al.  The cellular origins of the outer retinal bands in optical coherence tomography images. , 2014, Investigative ophthalmology & visual science.

[9]  Alexander Meadway,et al.  High-speed adaptive optics for imaging of the living human eye. , 2015, Optics express.

[10]  W B Amos,et al.  Re‐evaluation of differential phase contrast (DPC) in a scanning laser microscope using a split detector as an alternative to differential interference contrast (DIC) optics , 2003, Journal of microscopy.

[11]  Jerome Mertz,et al.  Wide-field fluorescence sectioning with hybrid speckle and uniform-illumination microscopy. , 2008, Optics letters.

[12]  Laurent M. Mugnier,et al.  Sub-pixel image registration with a maximum likelihood estimator. Application to the first adaptive optics observations of Arp 220 in the L' band , 2005 .

[13]  Krishnakumar Venkateswaran,et al.  Optical slicing of human retinal tissue in vivo with the adaptive optics scanning laser ophthalmoscope. , 2005, Applied optics.

[14]  F. Rossant,et al.  Adaptive optics ophthalmoscopy: Application to age-related macular degeneration and vascular diseases , 2018, Progress in Retinal and Eye Research.

[15]  Toco Y P Chui,et al.  The use of forward scatter to improve retinal vascular imaging with an adaptive optics scanning laser ophthalmoscope , 2012, Biomedical optics express.

[16]  D R Williams,et al.  Supernormal vision and high-resolution retinal imaging through adaptive optics. , 1997, Journal of the Optical Society of America. A, Optics, image science, and vision.

[17]  Andrew B Metha,et al.  Reactivity in the human retinal microvasculature measured during acute gas breathing provocations , 2017, Scientific Reports.

[18]  T. Hebert,et al.  Adaptive optics scanning laser ophthalmoscopy. , 2002, Optics express.

[19]  A Roorda,et al.  What can adaptive optics do for a scanning laser ophthalmoscope ? , 2006, Bulletin de la Societe belge d'ophtalmologie.

[20]  A. Yoshida,et al.  Radiating retinal folds detected by scanning laser ophthalmoscopy using a diode laser in a dark-field mode in idiopathic macular holes , 1998, Graefe's Archive for Clinical and Experimental Ophthalmology.

[21]  J. Schuman,et al.  Optical coherence tomography. , 2000, Science.

[22]  ESSICA,et al.  High temporal resolution aberrometry in a 50-eye population and implications for adaptive optics error budget , 2017 .

[23]  Serge Meimon,et al.  Fixational eye movement: a negligible source of dynamic aberration. , 2018, Biomedical optics express.

[24]  A. Roorda,et al.  Adaptive optics ophthalmoscopy. , 2015, Annual review of vision science.

[25]  Ece.,et al.  High loop rate Adaptive Optics Flood Illumination Ophthalmoscope with structured illumination capability , 2018 .

[26]  David Alonso-Caneiro,et al.  Use of focus measure operators for characterization of flood illumination adaptive optics ophthalmoscopy image quality. , 2018, Biomedical optics express.

[27]  Austin Roorda,et al.  Disruption of the retinal parafoveal capillary network in type 2 diabetes before the onset of diabetic retinopathy. , 2011, Investigative ophthalmology & visual science.