Immobilization device for in vivo and in vitro multimodality image registration of rodent tumors.

Biological image-guided radiotherapy requires that PET accurately identifies biologically relevant sub-volumes within a tumor. In this framework, an immobilization device was developed to study multi-imaging (CT, micro-MRI, micro-PET, and autoradiography) registration of mouse tumors. The registration accuracy assessed by calculating the average minimal distance between two skew lines was in the order of 0.2-0.3 mm.

[1]  H. Withers,et al.  Immunological resistance to pulmonary metastases in C3Hf-Bu mice bearing syngeneic fibrosarcoma of different sizes. , 1974, Cancer research.

[2]  Roee S. Lazebnik,et al.  Three-Dimensional Registration of Magnetic Resonance Image Data to Histological Sections with Model-Based Evaluation , 2005, Annals of Biomedical Engineering.

[3]  John Humm,et al.  Animal-specific positioning molds for registration of repeat imaging studies: comparative microPET imaging of F18-labeled fluoro-deoxyglucose and fluoro-misonidazole in rodent tumors. , 2006, Nuclear medicine and biology.

[4]  Keh-Shih Chuang,et al.  A three-dimensional registration method for automated fusion of micro PET-CT-SPECT whole-body images , 2005, IEEE Transactions on Medical Imaging.

[5]  R. Leahy,et al.  Digimouse: a 3D whole body mouse atlas from CT and cryosection data , 2007, Physics in medicine and biology.

[6]  Bradford A Moffat,et al.  A Methodology for Registration of a Histological Slide and In Vivo MRI Volume Based on Optimizing Mutual Information , 2006, Molecular imaging.

[7]  Robert M. Lewitt,et al.  Application of the row action maximum likelihood algorithm with spherical basis functions to clinical PET imaging , 2001 .

[8]  Abraham Z Snyder,et al.  Registration of [18F]FDG microPET and small-animal MRI. , 2005, Nuclear medicine and biology.

[9]  Simon K. Warfield,et al.  Efficient multi-modal dense field non-rigid registration: alignment of histological and section images , 2005, Medical Image Anal..

[10]  Patrick L Chow,et al.  A method of image registration for small animal, multi-modality imaging , 2006, Physics in medicine and biology.

[11]  Y Chen,et al.  A stereotactic method for the three-dimensional registration of multi-modality biologic images in animals: NMR, PET, histology, and autoradiography. , 2003, Medical physics.