Genome stability: Transgenerational mutation by radiation

Parental exposure to ionizing radiation increases the frequency of germline mutations detectable in the next generation. Parental exposure can also increase the rate of mutation in somatic cells and confer a predisposition to cancer in offspring, suggesting that there could be an indirect effect of radiation on somatic genome stability that is transmissible through the germ line of the irradiated parents. We have found that this indirect effect extends to the germ line of unexposed first-generation offspring in mice, as revealed by an increased instability of repeat-DNA sequences in their descendants.

[1]  J. Day,et al.  Genomic instability induced by ionizing radiation. , 1996, Radiation research.

[2]  I. Vorobtsova,et al.  Promotion of skin tumors by 12-O-tetradecanoylphorbol-13-acetate in two generations of descendants of male mice exposed to X-ray irradiation. , 1993, Mutation research.

[3]  T. Nomura,et al.  X-ray-induced germ-line mutation leading to tumors. Its manifestation in mice given urethane post-natally. , 1983, Mutation research.

[4]  K. Lee.  The Cancer Research Campaign , 2000, Current Biology.

[5]  Joël Zlotogora,et al.  Germ line mosaicism , 1998, Human Genetics.

[6]  Y E Dubrova,et al.  Stage specificity, dose response, and doubling dose for mouse minisatellite germ-line mutation induced by acute radiation. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[7]  O. Raabe,et al.  In vitro fertilization rate of mouse oocytes with spermatozoa from the F1 offspring of males irradiated with 1.0 Gy 137Cs gamma-rays. , 1997, Mutation research.

[8]  A J Jeffreys,et al.  Characterization of a highly unstable mouse minisatellite locus: evidence for somatic mutation during early development. , 1989, Genomics.

[9]  R Holliday,et al.  The inheritance of epigenetic defects. , 1987, Science.

[10]  A. Riches,et al.  Genomic instability in haematopoietic cells of F1 generation mice of irradiated male parents. , 1997, Mutagenesis.

[11]  A J Jeffreys,et al.  A tetranucleotide repeat mouse minisatellite displaying substantial somatic instability during early preimplantation development. , 1993, Genomics.

[12]  J. Herman,et al.  Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. , 1998, Proceedings of the National Academy of Sciences of the United States of America.