and Detection of Distinct Disease Subtypes Humoral Autoimmunity in Type 1 Diabetes: Prediction, Significance,

[1]  H. Doyle,et al.  Autoantigenesis: the evolution of protein modifications in autoimmune disease. , 2012, Current opinion in immunology.

[2]  M. Rewers,et al.  Distinguishing Persistent Insulin Autoantibodies With Differential Risk , 2011, Diabetes.

[3]  P. Marrack,et al.  Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse , 2011, Proceedings of the National Academy of Sciences.

[4]  J. Krischer,et al.  Rituximab Selectively Suppresses Specific Islet Antibodies , 2011, Diabetes.

[5]  M. Atkinson,et al.  Loss of Intra-Islet CD20 Expression May Complicate Efficacy of B-Cell–Directed Type 1 Diabetes Therapies , 2011, Diabetes.

[6]  A. Sherman,et al.  Investigating the Role of T-Cell Avidity and Killing Efficacy in Relation to Type 1 Diabetes Prediction , 2011, PloS one.

[7]  J. Skyler.  Immune intervention for type 1 diabetes mellitus. , 2011, International journal of clinical practice. Supplement.

[8]  J. Palmer,et al.  Identification of Autoantibody-Negative Autoimmune Type 2 Diabetic Patients , 2010, Diabetes Care.

[9]  A. Gomez,et al.  Antibody effector mechanisms in myasthenia gravis—Pathogenesis at the neuromuscular junction , 2010, Autoimmunity.

[10]  P. Bingley,et al.  Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for national institute of diabetes and digestive and kidney diseases consortia. , 2010, The Journal of clinical endocrinology and metabolism.

[11]  G. Omenn,et al.  Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetes. , 2010, Endocrinology.

[12]  G. Rutter,et al.  Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion , 2010, Diabetologia.

[13]  Mark S. Anderson,et al.  Autoimmune polyendocrine syndromes: clues to type 1 diabetes pathogenesis. , 2010, Immunity.

[14]  Jeffrey A. Bluestone,et al.  Genetics, pathogenesis and clinical interventions in type 1 diabetes , 2010, Nature.

[15]  Nichole Reisdorph,et al.  Chromogranin A is an autoantigen in type 1 diabetes , 2010, Nature Immunology.

[16]  H. Gil,et al.  Rituximab treatment of stiff-person syndrome in a patient with thymoma, diabetes mellitus and autoimmune thyroiditis , 2010, Journal of Clinical Neuroscience.

[17]  G. Eisenbarth,et al.  Triple chimeric islet autoantigen IA2-ZnT8WR to facilitate islet autoantibody determination. , 2010, Journal of immunological methods.

[18]  M. Wheeler,et al.  Zinc, a regulator of islet function and glucose homeostasis , 2009, Diabetes, obesity & metabolism.

[19]  L. Spain,et al.  Validity and Reproducibility of Measurement of Islet Autoreactivity by T-Cell Assays in Subjects With Early Type 1 Diabetes , 2009, Diabetes.

[20]  Mark S. Anderson,et al.  A novel myelin P0–specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy , 2009, The Journal of experimental medicine.

[21]  A. Skowera,et al.  Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture , 2009, Diabetes.

[22]  M. Cancro,et al.  In Vivo BLyS/BAFF Neutralization Ameliorates Islet-Directed Autoimmunity in Nonobese Diabetic Mice1 , 2008, The Journal of Immunology.

[23]  G. Eisenbarth,et al.  Identification of a Major Humoral Epitope in Slc30A8 (ZnT8) , 2008, Annals of the New York Academy of Sciences.

[24]  R. Haigh,et al.  Consequence of neo-antigenicity of the 'altered self'. , 2008, Rheumatology.

[25]  R. Tisch,et al.  B Lymphocyte Depletion by CD20 Monoclonal Antibody Prevents Diabetes in Nonobese Diabetic Mice despite Isotype-Specific Differences in FcγR Effector Functions1 , 2008, The Journal of Immunology.

[26]  Marian Rewers,et al.  The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes , 2007, Proceedings of the National Academy of Sciences.

[27]  R. A. Bailey,et al.  Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes , 2007, Nature Genetics.

[28]  G. Eisenbarth.  Update in type 1 diabetes. , 2007, The Journal of clinical endocrinology and metabolism.

[29]  L. Kuller,et al.  The Heterogeneity of Diabetes , 2007, Diabetes.

[30]  M. Peakman,et al.  Translational Mini‐Review Series on Type 1 Diabetes:
Systematic analysis of T cell epitopes in autoimmune diabetes , 2007, Clinical and experimental immunology.

[31]  F. Mastronardi,et al.  The Role of Citrullinated Proteins Suggests a Novel Mechanism in the Pathogenesis of Multiple Sclerosis , 2006, Neurochemical Research.

[32]  S. Müller,et al.  Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5 , 2006, Nature Cell Biology.

[33]  J. Bluestone,et al.  Regulatory T cells , 2006 .

[34]  M. Trucco,et al.  Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies , 2005, Pediatric diabetes.

[35]  Saroja Ramanujan,et al.  A comprehensive review of interventions in the NOD mouse and implications for translation. , 2005, Immunity.

[36]  G. Eisenbarth,et al.  Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice , 2005, Nature.

[37]  A. Favier,et al.  Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. , 2004, Diabetes.

[38]  G Strandberg,et al.  Anti-CCP antibody test predicts the disease course during 3 years in early rheumatoid arthritis (the Swedish TIRA project) , 2004, Annals of the rheumatic diseases.

[39]  Roberto Mallone,et al.  GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes. , 2004, Diabetes.

[40]  H. Kautiainen,et al.  Antibodies against cyclic citrullinated peptide (CCP) and levels of cartilage oligomeric matrix protein (COMP) in very early arthritis: relation to diagnosis and disease activity , 2004, Scandinavian journal of rheumatology.

[41]  L. Kuller,et al.  Islet cell autoimmunity in a triethnic adult population of the Third National Health and Nutrition Examination Survey. , 2004, Diabetes.

[42]  M. Knip,et al.  GAD65 antibody isotypes and epitope recognition during the prediabetic process in siblings of children with type I diabetes , 2004, Clinical and experimental immunology.

[43]  J. Ilonen,et al.  Insulin Autoantibody Isotypes during the Prediabetic Process in Young Children with Increased Genetic Risk of Type 1 Diabetes , 2004, Pediatric Research.

[44]  P. Bingley,et al.  Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics. , 2004, Diabetes.

[45]  I. Hirsch,et al.  What's in a name: latent autoimmune diabetes of adults, type 1.5, adult-onset, and type 1 diabetes. , 2003, Diabetes care.

[46]  E. Bonifacio,et al.  International Workshop on Lessons from Animal Models for Human Type 1 Diabetes , 2002, Annals of the New York Academy of Sciences.

[47]  S. Martin,et al.  Development of type 1 diabetes despite severe hereditary B-cell deficiency. , 2001, The New England journal of medicine.

[48]  A. Hämäläinen,et al.  The first signs of beta-cell autoimmunity appear in infancy in genetically susceptible children from the general population: the Finnish Type 1 Diabetes Prediction and Prevention Study. , 2001, The Journal of clinical endocrinology and metabolism.

[49]  G. Eisenbarth,et al.  Autoantibodies in human diabetes. , 2001, Current directions in autoimmunity.

[50]  E. Girbal-Neuhauser,et al.  The Major Synovial Targets of the Rheumatoid Arthritis-Specific Antifilaggrin Autoantibodies Are Deiminated Forms of the α- and β-Chains of Fibrin1 , 2001, The Journal of Immunology.

[51]  W. Cefalu,et al.  Efficacy of inhaled human insulin in type 1 diabetes mellitus: a randomised proof-of-concept study , 2001, The Lancet.

[52]  A. Tomlinson,et al.  Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4. , 1999, The Journal of clinical investigation.

[53]  M. Peakman,et al.  Autoimmunity in diabetic autonomic neuropathy: does the immune system get on your nerves? , 1998, Diabetic medicine : a journal of the British Diabetic Association.

[54]  A. Naji,et al.  B-Cells Are Required for the Initiation of Insulitis and Sialitis in Nonobese Diabetic Mice , 1997, Diabetes.

[55]  M. Atkinson,et al.  Quantitative thresholds of MHC class II I-E expressed on hemopoietically derived antigen-presenting cells in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection. , 1996, Journal of immunology.

[56]  J. Hutton,et al.  Molecular Cloning of Phogrin, a Protein-tyrosine Phosphatase Homologue Localized to Insulin Secretory Granule Membranes* , 1996, The Journal of Biological Chemistry.

[57]  H. Chase,et al.  Prediction of Type I Diabetes in First-Degree Relatives Using a Combination of Insulin, GAD, and ICA512bdc/IA-2 Autoantibodies , 1996, Diabetes.

[58]  A. Ziegler,et al.  Cellular Immune Response to Diverse Islet Cell Antigens in IDDM , 1996, Diabetes.

[59]  H. Kolb,et al.  HLA‐associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent‐onset insulin‐dependent diabetes mellitus , 1996, European journal of immunology.

[60]  M. Lan,et al.  Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. , 1994, DNA and cell biology.

[61]  M. Rowley,et al.  Latent Autoimmune Diabetes Mellitus in Adults (LADA): the Role of Antibodies to Glutamic Acid Decarboxylase in Diagnosis and Prediction of Insulin Dependency , 1994, Diabetic medicine : a journal of the British Diabetic Association.

[62]  M. Erlander,et al.  Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes , 1992, The Lancet.

[63]  D. Adler,et al.  Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[64]  S. Baekkeskov,et al.  Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase , 1990, Nature.

[65]  R. J. Keller,et al.  Cellular immunity to human insulin in individuals at high risk for the development of type I diabetes mellitus. , 1990, Journal of autoimmunity.

[66]  S. Fey,et al.  Revelation of Specificity of 64K Autoantibodies in IDDM Serums by High-Resolution 2-D Gel Electrophoresis: Unambiguous Identification of 64K Target Antigen , 1989, Diabetes.

[67]  A. Vinik,et al.  Anti-Sympathetic Ganglia Antibodies and Postural Blood Pressure in IDDM Subjects of Varying Duration and Patients at High Risk of Developing IDDM , 1989, Diabetes Care.

[68]  P. De Camilli,et al.  Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I diabetes mellitus. , 1988, The New England journal of medicine.

[69]  G. Eisenbarth.  Type I diabetes mellitus. A chronic autoimmune disease. , 1986 .

[70]  D. R. Gamble,et al.  In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. , 1985, The New England journal of medicine.

[71]  J. Palmer,et al.  Insulin antibodies in insulin-dependent diabetics before insulin treatment. , 1983, Science.

[72]  D. Doniach,et al.  Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. , 1974, Lancet.

[73]  R. LaPorte,et al.  Progression to insulin-requiring diabetes in seronegative prediabetic subjects: the role of two HLA-DQ high-risk haplotypes , 2002, Diabetologia.

[74]  A. Tobin,et al.  Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes. , 1993, The Journal of clinical investigation.

[75]  C. Boitard,et al.  Peripherin: an islet antigen that is cross-reactive with nonobese diabetic mouse class II gene products. , 1992, Proceedings of the National Academy of Sciences of the United States of America.