论文信息 - Quantitative fluorescence microscopy yields distributions of concentration and photobleaching rate in 5ALA-induced Protoporphyrin IX in cell population

Quantitative fluorescence microscopy yields distributions of concentration and photobleaching rate in 5ALA-induced Protoporphyrin IX in cell population

The variation in photodynamic dose achieved with protoporphyrin Ix (PPIX) and laser radiation was assessed in a cancer cell culture. The distributions of initial PPIX concentration, photobleaching light dose, and photodynamic dose were measured on 124 individual cells (rat mammary cancer cell line, MTF7) using video fluorescence microscopy.

Steven L. Jacques | Kunio Awazu | S. Jacques | K. Awazu

[1] S. G. Bown,et al. Photodynamic therapy of the normal rat stomach: a comparative study between di-sulphonated aluminium phthalocyanine and 5-aminolaevulinic acid. , 1992, British Journal of Cancer.

[2] Z. Malik,et al. Destruction of erythroleukaemic cells by photoactivation of endogenous porphyrins. , 1987, British Journal of Cancer.

[3] D. Phillips,et al. Fluorescence distribution and photodynamic effect of ALA-induced PP IX in the DMH rat colonic tumour model. , 1992, British Journal of Cancer.

[4] J C Kennedy,et al. Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with localized protoporphyrin IX fluorescence. , 1990, The American journal of pathology.

[5] I Z Ades. Heme production in animal tissues: the regulation of biogenesis of delta-aminolevulinate synthase. , 1990, The International journal of biochemistry.

[6] I. Z. Ades,et al. Heme production in animal tissues: The regulation of biogenesis of δ-aminolevulinate synthase , 1990 .

[7] M S Patterson,et al. In vivo TESTS OF THE CONCEPT OF PHOTODYNAMIC THRESHOLD DOSE IN NORMAL RAT LIVER PHOTOSENSITIZED BY ALUMINUM CHLOROSULPHONATED PHTHALOCYANINE , 1990, Photochemistry and photobiology.