The use of equivalent electronic circuits in simulating physiological processes

This paper is a report on one of the modern approaches to teaching physiology to postgraduate medical students. The aim is to promote qualitative as well as quantitative analog thinking about physiological processes. To meet this aim the concept of equivalent electronic circuits was introduced in teaching. Two examples of simulation of physiological phenomena by equivalent electronic circuits are described: (1) a pump for building-up the concentration gradient of a solute and (2) drug distribution in body compartments after single or repeated administration and extracellular volume measurement. The use of the latter circuit in teaching was tested in two generations of postgraduate medical students. They showed an increasing interest for this type of teaching because simulation graphs were almost identical to those shown in textbooks and physicians manuals.

[1]  Robert Zorec,et al.  13 - Electrophysiological Study of Hormone Secretion by Single Adenohypophyseal Cells , 1991 .

[2]  Marjan Kordas,et al.  Cardiovascular physiology: simulation of steady state and transient phenomena by using the equivalent electronic circuit , 2002, Comput. Methods Programs Biomed..

[3]  David Bradley,et al.  The Physiology of Excitable Cells, 4th edn. By DAVID J. AIDLEY. (Pp. xii+477; illustrated; £70/$95 hardback, £24.95/$47.95 paperback; ISBN 0 521 57415 3 hardback, 0 521 57421 8 paperback.) Cambridge: Cambridge University Press. 1998. , 1999 .

[4]  H. Mitsuya,et al.  Clinical pharmacology of 3'-azido-2',3'-dideoxythymidine (zidovudine) and related dideoxynucleosides. , 1989, The New England journal of medicine.

[5]  D. Peterec,et al.  Current Pump-Assisted Voltage-Clamp Apparatus , 1991 .

[6]  M. Kordas,et al.  On the role of junctional cholinesterase in determining the time course of the end‐plate current. , 1977, The Journal of physiology.

[7]  B. Katz Nerve, Muscle and Synapse , 1966 .

[8]  M. Kordas,et al.  A study of the end‐plate potential in sodium‐deficient solution , 1968, The Journal of physiology.

[9]  D. Peterec,et al.  The voltage—clamp apparatus assisted by a ‘current pump’ , 1989, Journal of Neuroscience Methods.

[10]  M. Kordas,et al.  An attempt at a simulation of the end-plate current. , 1975, Journal of theoretical biology.

[11]  T. M. Devlin,et al.  Textbook of biochemistry: With clinical correlations , 1982 .

[12]  M. Kordaš,et al.  An attempt at an analysis of the factors determining the time course of the end‐plate current , 1972 .

[13]  L. R. Gieszl,et al.  Hint for squint: a computer reliant diagnostic aid for strabismus , 1983 .

[14]  Robert F. Schmidt Grundriß der Neurophysiologie , 1972 .