Treatment of infections associated with surgical implants.

About half of all nosocomial infections are associated with indwelling devices. Infections associated with implanted surgical devices are particularly difficult to deal with because they can require prolonged antibiotic treatment and repeated surgical procedures. This review summarizes the diagnostic challenges and explains the approaches to managing infections that are associated with various devices, including prosthetic heart valves, vascular grafts, pacemakers and defibrillators, and joint prostheses.

[1]  G. Sirchia,et al.  Fresh and Cryopreserved Arterial Homografts in the Treatment of Prosthetic Graft Infections: Experience of the Italian Collaborative Vascular Homograft Group , 1998, Annals of vascular surgery.

[2]  A. Lumsden,et al.  Management of infected hemodialysis access grafts using cryopreserved human vein allografts. , 2002, American journal of surgery.

[3]  A. Hanssen,et al.  Staphylococcus aureus prosthetic joint infection treated with debridement and prosthesis retention. , 1997, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[4]  U. Steger,et al.  Surgical management of prosthetic vascular graft infection: comparative retrospective analysis of 30 consecutive cases. , 2002, VASA. Zeitschrift fur Gefasskrankheiten.

[5]  Claude Carbón,et al.  Prosthetic joint infection: when can prosthesis salvage be considered? , 1999, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[6]  J. Mulcahy.  Surgical management of penile prosthesis complications , 2000, International Journal of Impotence Research.

[7]  R. Swanton,et al.  Mortality from infective endocarditis: clinical predictors of outcome , 2002, Heart.

[8]  R. Darouiche.  Antimicrobial approaches for preventing infections associated with surgical implants. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[9]  J. Ruskin,et al.  Long-term infection rates associated with the pectoral versus abdominal approach to cardioverter- defibrillator implants. , 2001, The American journal of cardiology.

[10]  G. Moneta,et al.  Improved results with conventional management of infrarenal aortic infection. , 1999, Journal of vascular surgery.

[11]  G. Cooper,et al.  Effect of temperature on the Brugada ECG , 2003, Heart.

[12]  B. Browne,et al.  Cerebral ventricular shunts. , 1999, The Journal of emergency medicine.

[13]  P. Kreienberg,et al.  Alternative approach for management of infected aortic grafts. , 1997, Journal of vascular surgery.

[14]  J. A. Nelson,et al.  Prolonged suppressive antibiotic therapy for infected orthopedic prostheses. , 1998, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[15]  M C Oz,et al.  Long-term use of a left ventricular assist device for end-stage heart failure. , 2001, The New England journal of medicine.

[16]  J. Costerton,et al.  Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms , 2002, Clinical Microbiology Reviews.

[17]  D Lacroix,et al.  Systemic infection related to endocarditis on pacemaker leads: clinical presentation and management. , 1997, Circulation.

[18]  R. Grimer,et al.  Two-Stage Revision for Infected Endoprostheses Used in Tumor Surgery , 2002, Clinical orthopaedics and related research.

[19]  Richard A. Lange,et al.  Prosthetic heart valves. , 1996, The New England journal of medicine.

[20]  S. Wilson,et al.  Inflatable penile implant infection: predisposing factors and treatment suggestions. , 1995, The Journal of urology.

[21]  P L Hibberd,et al.  Staphylococcus aureus prosthetic valve endocarditis: optimal management and risk factors for death. , 1998, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[22]  M. Oz,et al.  Infections During Left Ventricular Assist Device Support Do Not Affect Posttransplant Outcomes , 2000, Circulation.

[23]  M. Dan,et al.  Successful Management of an Infected Implantable Cardioverter Defibrillator with Oral Antibiotics and without Removal of the Device , 1997, Pacing and clinical electrophysiology : PACE.

[24]  J. Coselli,et al.  Management of thoracic aortic graft infections. , 1999, The Annals of thoracic surgery.

[25]  Y. Ouchi,et al.  Changing spectrum of infective endocarditis: review of 194 episodes over 20 years. , 2003, Circulation journal : official journal of the Japanese Circulation Society.

[26]  R. Wittler,et al.  Treatment of cerebrospinal fluid shunt infections: a decision analysis , 2002, The Pediatric infectious disease journal.

[27]  A. Widmer.  New developments in diagnosis and treatment of infection in orthopedic implants. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[28]  W M O'Fallon,et al.  Complications leading to surgery after breast implantation. , 1997, The New England journal of medicine.

[29]  M C Oz,et al.  Implantable left ventricular assist devices. , 1998, The New England journal of medicine.

[30]  D. Sexton,et al.  The Impact of Surgical-Site Infections Following Orthopedic Surgery at a Community Hospital and a University Hospital Adverse Quality of Life, Excess Length of Stay, and Extra Cost , 2002, Infection Control & Hospital Epidemiology.

[31]  W. Whitehead,et al.  The Treatment of Cerebrospinal Fluid Shunt Infections , 2001, Pediatric Neurosurgery.

[32]  B. Morrey,et al.  Treatment of Infection with Débridement and Retention of the Components following Hip Arthroplasty* , 1998, The Journal of bone and joint surgery. American volume.

[33]  Randolph P. Martin,et al.  The Role of Transesophageal Echocardiography in the Diagnosis and Management of Patients with Aortic Perivalvular Abscesses , 2001, The American journal of the medical sciences.

[34]  R. Darouiche.  Device-associated infections: a macroproblem that starts with microadherence. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[35]  J. Drake,et al.  Repeat Cerebrospinal Fluid Shunt Infection in Children , 2001, Pediatric Neurosurgery.

[36]  L. Reilly.  Aortic Graft Infection: Evolution in Management , 2002, Cardiovascular surgery.

[37]  J. Kestle,et al.  Ventricular shunting for hydrocephalus in children: patients, procedures, surgeons and institutions in English Canada, 1989-2001. , 2002, European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie.

[38]  F. Isobe,et al.  Early and late outcomes after reoperation for prosthetic valve endocarditis. , 2001, The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi.

[39]  J. Christenson,et al.  Aorto-Enteric Fistula is a Serious Complication to Aortic Surgery. Modern Trends in Diagnosis and Therapy , 2003, Cardiovascular surgery.

[40]  H. Boxma,et al.  Randomised controlled trial of single-dose antibiotic prophylaxis in surgical treatment of closed fractures: the Dutch Trauma Trial , 1996, The Lancet.

[41]  P. McCarthy,et al.  Implantable LVAD infections: implications for permanent use of the device. , 1996, The Annals of thoracic surgery.

[42]  P. McCarthy,et al.  Infections in Implantable Cardioverter Defibrillator Patients , 1990, Pacing and clinical electrophysiology : PACE.

[43]  T. Ferguson,et al.  The additional hospital costs generated in the management of complications of pacemaker and defibrillator implantations. , 1996, The Journal of thoracic and cardiovascular surgery.

[44]  J. Costerton,et al.  Bacterial biofilms: a common cause of persistent infections. , 1999, Science.

[45]  E. Wong,et al.  Staphylococcus aureus and Other Bacteremias in Hemodialyis Patients: Antibiotic Therapy and Surgical Removal of Access Site , 2000, Infection.

[46]  P E Ochsner,et al.  Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Foreign-Body Infection (FBI) Study Group. , 1998, JAMA.

[47]  R. Hye,et al.  Management of infectious and cutaneous complications in vascular access. , 1997, Seminars in Vascular Surgery.

[48]  A. Hanssen,et al.  Outcome of penicillin-susceptible streptococcal prosthetic joint infection treated with debridement and retention of the prosthesis. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[49]  D. Raoult,et al.  Ambulatory Treatment of Multidrug-ResistantStaphylococcus-Infected Orthopedic Implants with High-Dose Oral Co-trimoxazole (Trimethoprim-Sulfamethoxazole) , 1998, Antimicrobial Agents and Chemotherapy.