Modulation of GITR for cancer immunotherapy.

[1]  D. Tyler,et al.  Enhancement of anti‐tumor immunity through local modulation of CTLA‐4 and GITR by dendritic cells , 2011, European journal of immunology.

[2]  T. Watts,et al.  T‐cell intrinsic effects of GITR and 4‐1BB during viral infection and cancer immunotherapy , 2011, Immunological reviews.

[3]  N. Morris,et al.  Science gone translational: the OX40 agonist story , 2011, Immunological reviews.

[4]  E. Mazzon,et al.  GITR Gene Deletion and GITR-Fc Soluble Protein Administration Inhibit Multiple Organ Failure Induced by Zymosan , 2011, Shock.

[5]  R. Maizels,et al.  Th2 Responses to Helminth Parasites Can Be Therapeutically Enhanced by, but Are Not Dependent upon, GITR–GITR Ligand Costimulation In Vivo , 2011, The Journal of Immunology.

[6]  J. Allison,et al.  Combination CTLA-4 Blockade and 4-1BB Activation Enhances Tumor Rejection by Increasing T-Cell Infiltration, Proliferation, and Cytokine Production , 2011, PloS one.

[7]  E. Mazzon,et al.  The glucocorticoid‐induced TNF receptor family‐related protein (GITR) is critical to the development of acute pancreatitis in mice , 2011, British journal of pharmacology.

[8]  Ash A. Alizadeh,et al.  CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies. , 2011, Blood.

[9]  Peisheng Zhang,et al.  Stimulation of the Glucocorticoid-Induced TNF Receptor Family-Related Receptor on CD8 T Cells Induces Protective and High-Avidity T Cell Responses to Tumor-Specific Antigens , 2011, The Journal of Immunology.

[10]  P. Pandolfi,et al.  CD8 T Cell-Intrinsic GITR Is Required for T Cell Clonal Expansion and Mouse Survival following Severe Influenza Infection , 2010, The Journal of Immunology.

[11]  J. Qiu,et al.  Mature B Cells Are Critical to T-cell-mediated Tumor Immunity Induced by an Agonist Anti-GITR Monoclonal Antibody , 2010, Journal of immunotherapy.

[12]  P. Ascierto,et al.  Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. , 2010, Seminars in oncology.

[13]  H. Salih,et al.  Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation , 2010, Clinical & developmental immunology.

[14]  L. Vaickus,et al.  Development of TRX518, an aglycosyl humanized monoclonal antibody (Mab) agonist of huGITR. , 2010 .

[15]  C. Addey,et al.  Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy , 2010, Cancer Immunology, Immunotherapy.

[16]  J. Allison,et al.  Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals , 2010, Clinical Cancer Research.

[17]  J. Wolchok,et al.  Agonist Anti-GITR Monoclonal Antibody Induces Melanoma Tumor Immunity in Mice by Altering Regulatory T Cell Stability and Intra-Tumor Accumulation , 2010, PloS one.

[18]  H. Rammensee,et al.  CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells. , 2010, Blood.

[19]  M. Croft Control of immunity by the TNFR-related molecule OX40 (CD134). , 2010, Annual review of immunology.

[20]  C. Loddenkemper,et al.  Combining T-cell Vaccination and Application of Agonistic Anti-GITR mAb (DTA-1) Induces Complete Eradication of HPV Oncogene Expressing Tumors in Mice , 2010, Journal of immunotherapy.

[21]  L. Chatenoud,et al.  Key Role of the GITR/GITRLigand Pathway in the Development of Murine Autoimmune Diabetes: A Potential Therapeutic Target , 2009, PloS one.

[22]  H. Ikeda,et al.  Glucocorticoid‐induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigen‐specific CD8+ T cells with tumor regression , 2009, Cancer science.

[23]  D. Boczkowski,et al.  Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy , 2009, Cancer Gene Therapy.

[24]  J. Wolchok,et al.  OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis , 2009, The Journal of experimental medicine.

[25]  R. Houot,et al.  T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy. , 2009, Blood.

[26]  T. Watts,et al.  Endogenous 4-1BB Ligand Plays a Critical Role in Protection from Influenza-Induced Disease1 , 2009, The Journal of Immunology.

[27]  C. Riccardi,et al.  GITR: a modulator of immune response and inflammation. , 2009, Advances in experimental medicine and biology.

[28]  L. Old,et al.  Regulatory T cell-resistant CD8+ T cells induced by glucocorticoid-induced tumor necrosis factor receptor signaling. , 2008, Cancer research.

[29]  M. Colombo,et al.  OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection , 2008, The Journal of experimental medicine.

[30]  R. Nussenblatt,et al.  Glucocorticoid-induced Tumor Necrosis Factor Receptor Negatively Regulates Activation of Human Primary Natural Killer (NK) Cells by Blocking Proliferative Signals and Increasing NK Cell Apoptosis* , 2008, Journal of Biological Chemistry.

[31]  S. Almo,et al.  Evolution of GITRL immune function: Murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily , 2008, Proceedings of the National Academy of Sciences.

[32]  J. Lear,et al.  Structural basis for ligand-mediated mouse GITR activation , 2008, Proceedings of the National Academy of Sciences.

[33]  P. Zhou,et al.  Pivotal Roles of CD4+ Effector T cells in Mediating Agonistic Anti-GITR mAb-Induced-Immune Activation and Tumor Immunity in CT26 Tumors , 2007, The Journal of Immunology.

[34]  H. Rammensee,et al.  Cancer immunoediting by GITR (glucocorticoid‐induced TNF‐related protein) ligand in humans: NK cell/tumor cell interactions , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[35]  Agonistic antibodies to human glucocorticoid-induced tumor necrosis factor receptor as potential stimulators of T cell immunity for the treatment of cancer and viral infections , 2007 .

[36]  C. Riccardi,et al.  GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in mice , 2006, Gut.

[37]  E. Mazzon,et al.  Genetic and pharmacological inhibition of GITR‐GITRL interaction reduces chronic lung injury induced by bleomycin instillation , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[38]  S. Quezada,et al.  CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. , 2006, The Journal of clinical investigation.

[39]  E. Mazzon,et al.  Proinflammatory Role of Glucocorticoid-Induced TNF Receptor-Related Gene in Acute Lung Inflammation1 , 2006, The Journal of Immunology.

[40]  M. V. D. van den Brink,et al.  Glucocorticoid-Induced TNF Receptor Family Related Gene Activation Overcomes Tolerance/Ignorance to Melanoma Differentiation Antigens and Enhances Antitumor Immunity1 , 2006, The Journal of Immunology.

[41]  J. Wolchok,et al.  Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity. , 2006, Cancer research.

[42]  Yong‐jun Liu,et al.  glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL) Human plasmacytoid predendritic cells activate NK cells through , 2008 .

[43]  T. Nomura,et al.  Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells , 2005, The Journal of experimental medicine.

[44]  B. Rouse,et al.  In Vivo Kinetics of GITR and GITR Ligand Expression and Their Functional Significance in Regulating Viral Immunopathology , 2005, Journal of Virology.

[45]  E. Mazzon,et al.  Role of glucocorticoid‐induced TNF receptor family gene (GITR) in collagen‐induced arthritis , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[46]  R. Arch,et al.  Glucocorticoid-Induced TNF Receptor Functions as a Costimulatory Receptor That Promotes Survival in Early Phases of T Cell Activation1 , 2005, The Journal of Immunology.

[47]  T. Watts,et al.  TNF/TNFR family members in costimulation of T cell responses. , 2005, Annual review of immunology.

[48]  M. Colombo,et al.  Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR. , 2005, Blood.

[49]  E. Mazzon,et al.  Glucocorticoid‐induced TNF receptor family gene (GITR) knockout mice exhibit a resistance to splanchnic artery occlusion (SAO) shock , 2004, Journal of leukocyte biology.

[50]  Ethan M. Shevach,et al.  Engagement of Glucocorticoid-Induced TNFR Family-Related Receptor on Effector T Cells by its Ligand Mediates Resistance to Suppression by CD4+CD25+ T Cells , 2004, The Journal of Immunology.

[51]  A. Houghton,et al.  Concomitant Tumor Immunity to a Poorly Immunogenic Melanoma Is Prevented by Regulatory T Cells , 2004, The Journal of experimental medicine.

[52]  P. Pandolfi,et al.  GITR Activation Induces an Opposite Effect on Alloreactive CD4+ and CD8+ T Cells in Graft-Versus-Host Disease , 2004, The Journal of experimental medicine.

[53]  I. Ishikawa,et al.  Costimulation via Glucocorticoid-Induced TNF Receptor in Both Conventional and CD25+ Regulatory CD4+ T Cells1 , 2004, The Journal of Immunology.

[54]  S. Miller,et al.  Cutting Edge: Ligation of the Glucocorticoid-Induced TNF Receptor Enhances Autoreactive CD4+ T Cell Activation and Experimental Autoimmune Encephalomyelitis1 , 2004, The Journal of Immunology.

[55]  C. Riccardi,et al.  Frontline: GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations , 2004, European journal of immunology.

[56]  T. Watts,et al.  Expression and function of 4‐1BB during CD4 versus CD8 T cell responses in vivo , 2004, European journal of immunology.

[57]  E. Unanue,et al.  Regulation of autoimmune diabetes by non‐islet‐specific T cells — a role for the glucocorticoid‐induced TNF receptor , 2004, European journal of immunology.

[58]  H. Waldmann,et al.  Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[59]  Tetsuya Nakamura,et al.  Regulation of Murine Inflammatory Bowel Disease by CD25+ and CD25− CD4+ Glucocorticoid-Induced TNF Receptor Family-Related Gene+ Regulatory T Cells1 , 2003, The Journal of Immunology.

[60]  P. Pandolfi,et al.  Role of GITR in activation response of T lymphocytes. , 2002, Blood.

[61]  M. Byrne,et al.  CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. , 2002, Immunity.

[62]  J. Shimizu,et al.  Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance , 2002, Nature Immunology.

[63]  Guo-liang Yu,et al.  Identification of a Novel Activation-inducible Protein of the Tumor Necrosis Factor Receptor Superfamily and Its Ligand* , 1999, The Journal of Biological Chemistry.

[64]  A. Gurney,et al.  Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR , 1999, Current Biology.

[65]  C. Riccardi,et al.  A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[66]  K. Pollok,et al.  Inducible T cell antigen 4-1BB. Analysis of expression and function. , 1993, Journal of immunology.

[67]  R. North Down-regulation of the antitumor immune response. , 1985, Advances in cancer research.