Functional and structural differences in the hippocampus associated with memory deficits in adult survivors of acute lymphoblastic leukemia

Radiation and chemotherapy targeted to the central nervous system (CNS) can cause cognitive impairment, including impaired memory. These memory impairments may be referable to damage to hippocampal structures resulting from CNS treatment.

[1]  J. Fletcher,et al.  Neuropsychological sequelae of childhood cancer in long-term survivors. , 1985, Pediatrics.

[2]  L. Squire,et al.  The medial temporal lobe memory system , 1991, Science.

[3]  W. Reddick,et al.  Abnormal hippocampal development in children with medulloblastoma treated with risk-adapted irradiation. , 2004, AJNR. American journal of neuroradiology.

[4]  M. Monje,et al.  Irradiation induces neural precursor-cell dysfunction , 2002, Nature Medicine.

[5]  W. Bleyer,et al.  Prophylaxis and treatment of leukemia in the central nervous system and other sanctuaries. , 1985, Seminars in oncology.

[6]  M. Grever,et al.  Efficacy and morbidity of central nervous system "prophylaxis" in childhood acute lymphoblastic leukemia: eight years' experience with cranial irradiation and intrathecal methotrexate. , 1983, Blood.

[7]  K. Ligon,et al.  Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies , 2007, Annals of neurology.

[8]  P. Skrabanek Letter: Unexplained tetanic spasms. , 1974, Lancet.

[9]  Lisa H. Lu,et al.  Effects of Prenatal Methamphetamine Exposure on Verbal Memory Revealed with Functional Magnetic Resonance Imaging , 2009, Journal of developmental and behavioral pediatrics : JDBP.

[10]  B. Moore,et al.  Neurocognitive development of children after a cerebellar tumor in infancy: A longitudinal study. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[11]  M. Mishkin,et al.  Differential effects of early hippocampal pathology on episodic and semantic memory. , 1997, Science.

[12]  Amar Gajjar,et al.  Late neurocognitive sequelae in survivors of brain tumours in childhood. , 2004, The Lancet. Oncology.

[13]  M. Moleski,et al.  Neuropsychological, neuroanatomical, and neurophysiological consequences of CNS chemotherapy for acute lymphoblastic leukemia. , 2000, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

[14]  J. Desmond,et al.  Making memories: brain activity that predicts how well visual experience will be remembered. , 1998, Science.

[15]  R. Gelber,et al.  LATE EFFECTS OF CENTRAL NERVOUS SYSTEM TREATMENT OF ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDHOOD ARE SEX‐DEPENDENT , 1990, Developmental medicine and child neurology.

[16]  W. Scoville,et al.  LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS , 1957, Journal of neurology, neurosurgery, and psychiatry.

[17]  P. Yakovlev,et al.  The myelogenetic cycles of regional maturation of the brain , 1967 .

[18]  U. Bartels,et al.  Longitudinal evaluation of neurocognitive function after treatment for central nervous system germ cell tumors in childhood , 2011, Cancer.

[19]  Mark Noble,et al.  CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo , 2006, Journal of biology.

[20]  G. Mangun,et al.  Successful Verbal Encoding into Episodic Memory Engages the Posterior Hippocampus: A Parametrically Analyzed Functional Magnetic Resonance Imaging Study , 1998, The Journal of Neuroscience.

[21]  M. Rugg,et al.  Task-dependency of the neural correlates of episodic encoding as measured by fMRI. , 2001, Cerebral cortex.

[22]  F. Gage,et al.  Mechanisms and Functional Implications of Adult Neurogenesis , 2008, Cell.

[23]  J. Gabrieli,et al.  Memory encoding in Alzheimer's disease: an fMRI study of explicit and implicit memory. , 2005, Brain : a journal of neurology.

[24]  A. Dale,et al.  Building memories: remembering and forgetting of verbal experiences as predicted by brain activity. , 1998, Science.

[25]  R. Gelber,et al.  The relationship of sex and treatment modality to neuropsychologic outcome in childhood acute lymphoblastic leukemia. , 1992, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[26]  L. Squire,et al.  Simple and associative recognition memory in the hippocampal region. , 2001, Learning & memory.

[27]  J. Koolhaas,et al.  Long-lasting suppression of hippocampal cell proliferation and impaired cognitive performance by methotrexate in the rat , 2008, Behavioural Brain Research.

[28]  E. Neuwelt,et al.  Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy. , 1994, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[29]  J. Whitlock,et al.  A meta‐analysis of the neurocognitive sequelae of treatment for childhood acute lymphocytic leukemia , 2007, Pediatric blood & cancer.

[30]  K. Paller,et al.  Observing the transformation of experience into memory , 2002, Trends in Cognitive Sciences.

[31]  M. Albert,et al.  Medial temporal lobe function and structure in mild cognitive impairment , 2004, Annals of neurology.

[32]  A. Moghrabi,et al.  Results of Dana-Farber Cancer Institute Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1981–1995) , 2000, Leukemia.

[33]  Anthony D. Wagner,et al.  Posterior parietal cortex and episodic encoding: Insights from fMRI subsequent memory effects and dual-attention theory , 2009, Neurobiology of Learning and Memory.

[34]  R. Mulhern,et al.  Modeling radiation dosimetry to predict cognitive outcomes in pediatric patients with CNS embryonal tumors including medulloblastoma. , 2006, International journal of radiation oncology, biology, physics.

[35]  O. Abayomi Pathogenesis of Cognitive Decline Following Therapeutic Irradiation for Head and Neck Tumors , 2002, Acta oncologica.

[36]  C. Sainte-Rose,et al.  Long-term intellectual outcome in children with posterior fossa tumors according to radiation doses and volumes. , 1999, International journal of radiation oncology, biology, physics.

[37]  L. Rorke,et al.  Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: A Children's Cancer Group Study. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[38]  R. Packer,et al.  A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemotherapy: 2-year results. , 1989, Journal of neurosurgery.

[39]  D. Kondziolka,et al.  Adverse long-term effects of brain radiotherapy in adult low-grade glioma patients , 2001, Neurology.

[40]  M. Monje,et al.  Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy. , 2008, The oncologist.

[41]  W. Reddick,et al.  Predicting intellectual outcome among children treated with 35-40 Gy craniospinal irradiation for medulloblastoma. , 2003, Neuropsychology.

[42]  G. Tripp,et al.  Intellectual, neuropsychological, and academic functioning in long-term survivors of leukemia. , 2000, Journal of pediatric psychology.

[43]  Eric Bouffet,et al.  Change in neurocognitive functioning after treatment with cranial radiation in childhood. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[44]  M. Albert,et al.  Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD , 2005, Neurology.

[45]  A. Meadows,et al.  DECLINES IN IQ SCORES AND COGNITIVE DYSFUNCTIONS IN CHILDREN WITH ACUTE LYMPHOCYTIC LEUKAEMIA TREATED WITH CRANIAL IRRADIATION , 1981, The Lancet.

[46]  Hiroki Toda,et al.  Inflammatory Blockade Restores Adult Hippocampal Neurogenesis , 2003, Science.

[47]  M. Monje,et al.  Cranial radiation therapy and damage to hippocampal neurogenesis. , 2008, Developmental disabilities research reviews.

[48]  D. Delis,et al.  Early patterns of verbal memory impairment in children treated for medulloblastoma. , 2006, Neuropsychology.

[49]  Christopher J. Cannistraci,et al.  Working memory in survivors of childhood acute lymphocytic Leukemia: Functional neuroimaging analyses , 2010, Pediatric blood & cancer.

[50]  J. Kramer,et al.  Cognitive function in children with leukemia. Effect of radiation dose and time since irradiation , 1991, Cancer.