论文信息 - Mesenchymal chondrosarcoma of the maxilla: Report of a case

Mesenchymal chondrosarcoma of the maxilla: Report of a case

A rare case of mesenchymal chondrosarcoma of the right maxilla of a 46-year-old man was presented.The patient was treated by preoperative radiation with 3, 500 rad of linac which was uneffective, and then radical resection of the tumor and radical neck dissection were performed. Chemotherapy with high dose methotrexate and leucovorin was employed and was very effective for the recurrence of the intraoral wound one month after the surgical procedure. However, the administration of high dose methotrexate was stopped because of the complication of severe myelosuppression. Finally, he died due to bleeding from the recurrent tumor eight months after his first admission.Histopathologically, the biopsy specimen revealed numerous variably shaped cartilageous islands separated by sheets of poorly differentiated mesenchymal cell. The chondrocytes in most areas showed enlargement of the nuclei and an open chromatin network.

[1] R. Christensen. Mesenchymal chondrosarcoma of the jaws. , 1982, Oral surgery, oral medicine, and oral pathology.

[2] J. Pierce,et al. Mesenchymal chondrosarcoma of the mandible. , 1981, Oral surgery, oral medicine, and oral pathology.

[3] Rollo Jl,et al. Primary meningeal mesenchymal chondrosarcoma. , 1979 .

[4] K. Sato,et al. Chondrosarcoma of the jaws and facial skeleton: a review of the Japanese literature. , 1977, Journal of oral surgery.

[5] N. Jaffe,et al. High-dose methotrexate with citrovorum factor in osteogenic sarcoma--progress report II. , 1977, Cancer treatment reports.

[6] D. Dahlin,et al. Mesenchymal chondrosarcoma—observations on 30 new cases , 1971, Cancer.

[7] D. Dahlin,et al. Mesenchymal chondrosarcoma. Further observations on a new entity , 1962, Cancer.

[8] L. Lichtenstein,et al. Unusual benign and malignant chondroid tumors of bone. A survey of some mesenchymal cartilage tumors and malignant chondroblastic tumors, including a few multicentric ones, as well as many atypical benign chondroblastomas and chondromyxoid fibromas , 1959, Cancer.