Evaluation of the BIOSTAT® CultiBag STR family in terms of scalability

Re-usable bioreactors have been the gold standard for many decades resulting in a large knowledge base on process control. However, recently a trend is observed in the industry where single-use bioreactors are being implemented in modern upstream processes. As many of these bioreactors show discrepancies from the traditional design a strong need has been expressed for new single-use bioreactors resembled on a classical design. Such design enables the user to improve the scale-up process based on experience and well-established guidelines. During this process, variables such as tip speed, mixing time, oxygen transfer and specific power input have to be considered. In order to meet this demand of improved scalability Sartorius Stedim Biotech recently developed a new stirred single-use bioreactor up to 1000 L, the BIOSTAT® CultiBag STR. This poster characterizes the BIOSTAT® CultiBag STR family in terms of all relevant scale-up parameters linked to this specific bioreactor design.