CYTOTOXIC INTERACTIONS OF VIRUS SPECIFIC EFFECTOR CELLS WITH VIRUS INFECTED TARGETS OF DIFFERENT CELL TYPE *

The action of Sendai virus specific cytolytic T lymphocytes (CTL) against Sendai virus infected macrophages was found to be H‐2 restricted while Sendai virus infected cell lines, including fibroblasts and tumour cells, were lysed across the H‐2 barrier to some extent. The properties of the Meth‐A tumour cell, which was resistant to lysis by allogenic killer cells was investigated. Sendai virus specific CTL failed to kill Sendai virus infected Meth‐A cells but after vaccinia virus infection these target cells were susceptible to lysis by vaccinia virus specific CTL.

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