Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling

[1]  I. Amit,et al.  Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq , 2016, Cell.

[2]  Thomas M. Norman,et al.  Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens , 2016, Cell.

[3]  Adam P. Rosebrock,et al.  A global genetic interaction network maps a wiring diagram of cellular function , 2016, Science.

[4]  H. Clevers,et al.  TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype , 2016, EMBO molecular medicine.

[5]  L. Hood,et al.  A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51 , 2015, Nature Communications.

[6]  Daniel H. Lackner,et al.  A generic strategy for CRISPR-Cas9-mediated gene tagging , 2015, Nature Communications.

[7]  G. Superti-Furga,et al.  Gene essentiality and synthetic lethality in haploid human cells , 2015, Science.

[8]  Marco Y. Hein,et al.  A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances , 2015, Cell.

[9]  Edward L. Huttlin,et al.  The BioPlex Network: A Systematic Exploration of the Human Interactome , 2015, Cell.

[10]  Chun Jimmie Ye,et al.  A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks , 2015, Cell.

[11]  L. Vitagliano,et al.  Cullin 3 Recognition Is Not a Universal Property among KCTD Proteins , 2015, PloS one.

[12]  Henrik Molina,et al.  Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation. , 2015, Molecular cell.

[13]  B. Ebert,et al.  Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance , 2014, Nature Medicine.

[14]  Paul Theodor Pyl,et al.  HTSeq—a Python framework to work with high-throughput sequencing data , 2014, bioRxiv.

[15]  Marco Y. Hein,et al.  Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ * , 2014, Molecular & Cellular Proteomics.

[16]  Uwe Schulte,et al.  Auxiliary GABAB Receptor Subunits Uncouple G Protein βγ Subunits from Effector Channels to Induce Desensitization , 2014, Neuron.

[17]  L. Parts Genome‐wide mapping of cellular traits using yeast , 2014, Yeast.

[18]  L. Kruglyak,et al.  Genetics of single-cell protein abundance variation in large yeast populations , 2013, Nature.

[19]  S. Carr,et al.  Large-scale identification of ubiquitination sites by mass spectrometry , 2013, Nature Protocols.

[20]  J. Carette,et al.  Deciphering the Glycosylome of Dystroglycanopathies Using Haploid Screens for Lassa Virus Entry , 2013, Science.

[21]  G. Tall,et al.  Regulation of the G-protein Regulatory-Gαi Signaling Complex by Nonreceptor Guanine Nucleotide Exchange Factors* , 2012, The Journal of Biological Chemistry.

[22]  Andrei L. Turinsky,et al.  A Census of Human Soluble Protein Complexes , 2012, Cell.

[23]  T. Sixma,et al.  Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases. , 2011, Journal of structural biology.

[24]  J. Dye,et al.  Ebola virus entry requires the cholesterol transporter Niemann-Pick C1 , 2011, Nature.

[25]  Samie R Jaffrey,et al.  Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling , 2010, Nature Biotechnology.

[26]  B. Fakler,et al.  Native GABAB receptors are heteromultimers with a family of auxiliary subunits , 2010, Nature.

[27]  Aaron R. Quinlan,et al.  BEDTools: a flexible suite of utilities for comparing genomic features , 2010, Bioinform..

[28]  Carla P. Guimarães,et al.  Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens , 2009, Science.

[29]  Lior Pachter,et al.  Sequence Analysis , 2020, Definitions.

[30]  Ralf Herwig,et al.  ConsensusPathDB—a database for integrating human functional interaction networks , 2008, Nucleic Acids Res..

[31]  Cole Trapnell,et al.  Ultrafast and memory-efficient alignment of short DNA sequences to the human genome , 2009, Genome Biology.

[32]  A. Alonso,et al.  KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases , 2008, The FEBS journal.

[33]  Anne E Carpenter,et al.  A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen , 2006, Cell.

[34]  Mike Tyers,et al.  BioGRID: a general repository for interaction datasets , 2005, Nucleic Acids Res..

[35]  Lincoln Stein,et al.  Reactome: a knowledgebase of biological pathways , 2004, Nucleic Acids Res..

[36]  H. Hamm,et al.  Phosducin‐like protein acts as a molecular chaperone for G protein βγ dimer assembly , 2005 .

[37]  L. Platanias Mechanisms of type-I- and type-II-interferon-mediated signalling , 2005, Nature Reviews Immunology.

[38]  D. Guertin,et al.  Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex , 2005, Science.

[39]  T. Blondal,et al.  Isolation and characterization of a thermostable RNA ligase 1 from a Thermus scotoductus bacteriophage TS2126 with good single-stranded DNA ligation properties , 2005, Nucleic acids research.

[40]  A. Lund,et al.  Polycomb complexes and silencing mechanisms. , 2004, Current opinion in cell biology.

[41]  Gary D Bader,et al.  Global Mapping of the Yeast Genetic Interaction Network , 2004, Science.

[42]  Yudong D. He,et al.  Functional Discovery via a Compendium of Expression Profiles , 2000, Cell.

[43]  D. Botstein,et al.  Cluster analysis and display of genome-wide expression patterns. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[44]  R. Wetzker,et al.  Gβγ Stimulates Phosphoinositide 3-Kinase-γ by Direct Interaction with Two Domains of the Catalytic p110 Subunit* , 1998, The Journal of Biological Chemistry.

[45]  P. Meikle,et al.  Diagnosis of lysosomal storage disorders: evaluation of lysosome-associated membrane protein LAMP-1 as a diagnostic marker. , 1997, Clinical chemistry.

[46]  P. Hawkins,et al.  A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits , 1994, Cell.