The effects and underlying mechanisms of medicine and food homologous flowers on the prevention and treatment of related diseases.

The theory of medicine and food homology has a long history in China. Numerous traditional Chinese medicinal could be used as both medicine and food. Many flower medicinal materials also belong to the homology of medicine and food, such as Chrysanthemum morifolium, Lonicera japonica, Crocus sativus, and Lonicera macranthoides. They mainly contain flavonoids, organic acids, terpenoids, and other active ingredients, which have a variety of medicinal values, including anti-inflammatory, anti-tumor, and antioxidant. There are many formulations and functional foods containing these plants in Chinese medicine, which have a variety of nutritional and health effects on the human body. In this review, 10 widely used flowers were selected to review their pharmacological activities, prevention and treatment of related diseases and underlying mechanisms, and discussed the current limitations and future development prospects, hoping to provide references for the research on the development and utilization of natural medical flowers. PRACTICAL APPLICATIONS: The "homology of medicine and food" flowers have a wide range of uses and are of great research value. In this paper, we introduce 10 "homology of medicine and food" flowers. Their active ingredients, pharmacological activities, and treatments for related diseases are reviewed, and the limitations and development prospects of the "homology of medicine and food" flowers are discussed. It is hoped that this will contribute to the development of the food and pharmacological fields.

[1]  Huanwang Jing,et al.  Simultaneous separation and determination of five chlorogenic acid isomers in Honeysuckle by capillary electrophoresis using self-synthesized ionic liquid [N-methylimidazole-β-cyclodextrin] [bromide] as separation selector. , 2022, Journal of Separation Science.

[2]  J. Sharifi‐Rad,et al.  The Pharmacological Activities of Crocus sativus L.: A Review Based on the Mechanisms and Therapeutic Opportunities of its Phytoconstituents , 2022, Oxidative medicine and cellular longevity.

[3]  OUP accepted manuscript , 2022, Journal of Chromatographic Science.

[4]  J. Simal-Gándara,et al.  The genus Crocus L.: A review of ethnobotanical uses, phytochemistry and pharmacology , 2021 .

[5]  L. Barreira,et al.  Nutritional and Functional Evaluation of Inula crithmoides and Mesembryanthemum nodiflorum Grown in Different Salinities for Human Consumption , 2021, Molecules.

[6]  L. Zhai,et al.  A Novel Biochemical Study of Anti-Dermal Fibroblast Replicative Senescence Potential of Panax Notoginseng Oligosaccharides , 2021, Frontiers in Pharmacology.

[7]  H. Ashktorab,et al.  Saffron and Its Major Ingredients’ Effect on Colon Cancer Cells with Mismatch Repair Deficiency and Microsatellite Instability , 2021, Molecules.

[8]  Le Chen,et al.  Comparison of Chemical Constituents and Pharmacological Effects of Different Varieties of Chrysanthemum Flos in China , 2021, Chemistry & biodiversity.

[9]  J. Gong,et al.  Exploring the Protective Effects and Mechanism of Crocetin From Saffron Against NAFLD by Network Pharmacology and Experimental Validation , 2021, Frontiers in Medicine.

[10]  I. Tzeng,et al.  Safflower Extract Inhibits ADP-Induced Human Platelet Aggregation , 2021, Plants.

[11]  J. Wan,et al.  Ginsenosides Rb2 and Rd2 isolated from Panax notoginseng flowers attenuate platelet function through P2Y12-mediated cAMP/PKA and PI3K/Akt/Erk1/2 signaling. , 2021, Food & function.

[12]  H. Tan,et al.  Rapid characterisation of xanthine oxidase inhibitors from the flowers of Chrysanthemum morifolium Ramat. Using metabolomics approach. , 2021, Phytochemical Analysis.

[13]  Li Li,et al.  Metabolomics study on the Periplocin-induced cardiotoxicity and the compatibility of Periplocin and Panax notoginseng saponins in reducing cardiotoxicity in rats by GC-MS. , 2021, Journal of separation science.

[14]  Xue-song Feng,et al.  Multi-marker scans coupled to high-resolution mass spectrometry strategy for global profiling combined with structure recognition of unknown trace chlorogenic acids in Lonicera Flos. , 2021, Talanta.

[15]  Zongxi Sun,et al.  Comparative Analysis of Compatibility Influence on Invigorating Blood Circulation for Combined Use of Panax Notoginseng Saponins and Aspirin Using Metabolomics Approach , 2021, Frontiers in Pharmacology.

[16]  M. Cruz,et al.  Anti-Inflammatory Activity of Calendula officinalis L. Flower Extract , 2021, Cosmetics.

[17]  K. Nasiri,et al.  Safflower seed oil improves steroidogenesis and spermatogenesis in rats with type II diabetes mellitus by modulating the genes expression involved in steroidogenesis, inflammation and oxidative stress. , 2021, Journal of ethnopharmacology.

[18]  S. Ying,et al.  Panax notoginseng protects the rat brain function from traumatic brain injury by inhibiting autophagy via mammalian targeting of rapamycin , 2021, Aging.

[19]  W. Hsu,et al.  Anti-inflammatory effects of Flos Lonicerae Japonicae Water Extract are regulated by the STAT/NF-κB pathway and HO-1 expression in Virus-infected RAW264.7 cells , 2021, International journal of medical sciences.

[20]  N. Castanon,et al.  Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission , 2021, Nutrients.

[21]  S. Yun,et al.  Safflower Seed Extract Attenuates the Development of Osteoarthritis by Blocking NF-κB Signaling , 2021, Pharmaceuticals.

[22]  Yaozu Xiang,et al.  Cardioprotection of Panax Notoginseng saponins against acute myocardial infarction and heart failure through inducing autophagy. , 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[23]  M. Frutos,et al.  Saffron bioactives crocin, crocetin and safranal: effect on oxidative stress and mechanisms of action , 2020, Critical reviews in food science and nutrition.

[24]  Yueheng Wu,et al.  Global Gene Expression Analysis Using RNA-seq Reveals the New Roles of Panax Notoginseng Saponins in Ischemic Cardiomyocytes. , 2020, Journal of ethnopharmacology.

[25]  N. Sadfi-Zouaoui,et al.  Antioxidant and Antimicrobial Potentials of Seed Oil from Carthamus tinctorius L. in the Management of Skin Injuries , 2020, Oxidative medicine and cellular longevity.

[26]  Yi Sun,et al.  Neuroprotective Effects of Safflower Flavonoid Extract in 6-Hydroxydopamine-Induced Model of Parkinson’s Disease May Be Related to its Anti-Inflammatory Action , 2020, Molecules.

[27]  A. Poła,et al.  TMPE Derived from Saffron Natural Monoterpene as Cytotoxic and Multidrug Resistance Reversing Agent in Colon Cancer Cells , 2020, International journal of molecular sciences.

[28]  Xinzhou Yang,et al.  Chrysanthemum ethanol extract induced loss of Kupffer cells via the mitochondria-dependent apoptotic pathway. , 2020, Food & function.

[29]  Mak-Soon Lee,et al.  Chrysanthemum morifolium Flower Extract Inhibits Adipogenesis of 3T3-L1 Cells via AMPK/SIRT1 Pathway Activation , 2020, Nutrients.

[30]  A. Bouyahya,et al.  Hypoglycemic Effect of Calendula arvensis Flowers is Mediated by Digestive Enzyme Inhibition , 2020 .

[31]  Zhiling Yu,et al.  A new bisepoxylignan dendranlignan A isolated from Chrysanthemum Flower inhibits the production of inflammatory mediators via the TLR4 pathway in LPS-induced H9c2 cardiomyocytes. , 2020, Archives of biochemistry and biophysics.

[32]  M. Daniyal,et al.  The flower head of Chrysanthemum morifolium Ramat. (Juhua): A paradigm of flowers serving as Chinese dietary herbal medicine. , 2020, Journal of ethnopharmacology.

[33]  E. Jeong,et al.  Safflower Seed Oil and Its Active Compound Acacetin Inhibit UVB-Induced Skin Photoaging , 2020, Journal of microbiology and biotechnology.

[34]  Y. Qiu,et al.  The Hypoglycemic and Renal Protection Properties of Crocin via Oxidative Stress-Regulated NF-κB Signaling in db/db Mice , 2020, Frontiers in Pharmacology.

[35]  I. Bozgeyik,et al.  Pharmacological properties and therapeutic potential of saffron (Crocus sativus L.) in osteosarcoma , 2019, The Journal of pharmacy and pharmacology.

[36]  S. Brand,et al.  Crocus Sativus L. (saffron) versus sertraline on symptoms of depression among older people with major depressive disorders–a double-blind, randomized intervention study , 2019, Psychiatry Research.

[37]  P. Drummond,et al.  Efficacy of a standardised saffron extract (affron®) as an add-on to antidepressant medication for the treatment of persistent depressive symptoms in adults: A randomised, double-blind, placebo-controlled study , 2019, Journal of psychopharmacology.

[38]  Zhenzhong Wang,et al.  Systems pharmacology uncovers serotonergic pathway mediated psychotherapeutic effects of Lonicerae Japonicae Flos , 2019, Journal of Functional Foods.

[39]  D. Visentin,et al.  A systematic review of Calendula officinalis extract for wound healing , 2019, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[40]  Yu-Tang Tung,et al.  Antifatigue Activity and Exercise Performance of Phenolic-Rich Extracts from Calendula officinalis, Ribes nigrum, and Vaccinium myrtillus , 2019, Nutrients.

[41]  M. Nounou,et al.  Nutraceuticals’ Novel Formulations: The Good, the Bad, the Unknown and Patents Involved , 2019, Recent patents on drug delivery & formulation.

[42]  Young Min Park,et al.  Antimelanogenic and Antimigration Properties of the Ethyl Acetate Fraction of Calendula officinalis Flowers on Melanoma Cells , 2019, Photochemistry and photobiology.

[43]  Xiaobin Pang,et al.  Chrysanthemum extract attenuates hepatotoxicity via inhibiting oxidative stress in vivo and in vitro , 2019, Food & nutrition research.

[44]  Jia Li,et al.  A new anti-inflammatory lignan from Lonicerae Japonicae flos , 2019, Natural product research.

[45]  Rui-ze Gong,et al.  A Comparative Study on the Effects of Different Parts of Panax ginseng on the Immune Activity of Cyclophosphamide-Induced Immunosuppressed Mice , 2019, Molecules.

[46]  Xianjun Meng,et al.  Polyphenol-rich blue honeysuckle extract alleviates silica-induced lung fibrosis by modulating Th immune response and NRF2/HO-1 MAPK signaling , 2019, Journal of Functional Foods.

[47]  I. Cho,et al.  Hepatoprotective effects of blue honeysuckle on CCl4‐induced acute liver damaged mice , 2018, Food science & nutrition.

[48]  A. Mishra,et al.  Cosmeceutical potential of geranium and calendula essential oil: Determination of antioxidant activity and in vitro sun protection factor , 2018, Journal of cosmetic dermatology.

[49]  KiaeiNarges,et al.  Investigation of the anti-inflammatory properties of Calendula nanoemulsion on skin cells , 2018 .

[50]  Huanwen Tang,et al.  Protective Effects of Aqueous Extracts of Flos lonicerae Japonicae against Hydroquinone-Induced Toxicity in Hepatic L02 Cells , 2018, Oxidative medicine and cellular longevity.

[51]  U. Kukongviriyapan,et al.  Suppression of Nrf2 confers chemosensitizing effect through enhanced oxidant-mediated mitochondrial dysfunction. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[52]  Yan Zhou,et al.  MiR-34a, as a suppressor, enhance the susceptibility of gastric cancer cell to luteolin by directly targeting HK1. , 2018, Gene.

[53]  P. Czabotar,et al.  The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation. , 2017, Seminars in cell & developmental biology.

[54]  L. Chuang,et al.  Antilipotoxicity Activity of Osmanthus fragrans and Chrysanthemum morifolium Flower Extracts in Hepatocytes and Renal Glomerular Mesangial Cells , 2017, Mediators of inflammation.

[55]  Wan-ling Wang,et al.  Sweroside eradicated leukemia cells and attenuated pathogenic processes in mice by inducing apoptosis. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[56]  N. Chung,et al.  Inhibitory Potential of Constituents from Osmanthus fragrans and Structural Analogues Against Advanced Glycation End Products, α-Amylase, α-Glucosidase, and Oxidative Stress , 2017, Scientific Reports.

[57]  Hsien-Da Huang,et al.  Honeysuckle aqueous extract and induced let-7a suppress dengue virus type 2 replication and pathogenesis. , 2017, Journal of ethnopharmacology.

[58]  Y. Miao,et al.  Effect of Total Flavonoids of Flos Sophorae on Glucose Levels, Serum Lipid and Antioxidation Ability in Diabetic Rats Model , 2016 .

[59]  Z. Zhao,et al.  Indazolo[3,2-b]quinazolinones Attack Hepatocellular Carcinoma Hep3B Cells by Inducing Mitochondrial-Dependent Apoptosis and Inhibition of Nrf2/ARE Signaling Pathway. , 2016, Current molecular medicine.

[60]  Wei-Jia Kong,et al.  Gastrodin Ameliorates Oxidative Stress and Proinflammatory Response in Nonalcoholic Fatty Liver Disease through the AMPK/Nrf2 Pathway , 2016, Phytotherapy research : PTR.

[61]  Jiajia Yang,et al.  Osmanthus fragrans Flower Extract and Acteoside Protect Against d-Galactose-Induced Aging in an ICR Mouse Model. , 2016, Journal of medicinal food.

[62]  G. Park,et al.  Downregulation of Cyclin D1 by Sophorae Flos through Proteasomal Degradation in Human Colorectal Cancer Cells , 2015 .

[63]  Shao Longquan,et al.  The ethanol extract of Osmanthus fragrans attenuates Porphyromonas gingivalis lipopolysaccharide-stimulated inflammatory effect through the nuclear factor erythroid 2-related factor-mediated antioxidant signalling pathway. , 2015, Archives of oral biology.

[64]  Jia-qing Cao,et al.  Osmanthus fragrans seeds, a source of secoiridoid glucosides and its antioxidizing and novel platelet-aggregation inhibiting function , 2015 .

[65]  Xi-dan Zhou,et al.  Towards a better understanding of medicinal uses of Carthamus tinctorius L. in traditional Chinese medicine: a phytochemical and pharmacological review. , 2014, Journal of ethnopharmacology.

[66]  Wang Chang-le Research Advance on Nutrients and Medicinal Value of Edible Flowers , 2014 .

[67]  G. Alonso,et al.  A contribution to nutritional studies on Crocus sativus flowers and their value as food , 2013 .

[68]  L. Guarente,et al.  High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. , 2012, Cell metabolism.

[69]  R. de Cabo,et al.  SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. , 2012, Cell metabolism.

[70]  Xiaofei Shang,et al.  Lonicera japonica Thunb.: Ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine , 2011, Journal of Ethnopharmacology.

[71]  Haeyong Lee,et al.  AICAR, an activator of AMPK, inhibits adipogenesis via the WNT/β-catenin pathway in 3T3-L1 adipocytes. , 2011, International journal of molecular medicine.

[72]  Weirong Yao,et al.  Composition and Antibacterial Activity of Essential Oils of Flos Sophorae Immaturus , 2011 .

[73]  J. Hyun,et al.  Dammarane-type saponins from the flower buds of Panax ginseng and their intracellular radical scavenging capacity. , 2010, Journal of agricultural and food chemistry.

[74]  Gaochao Zhou,et al.  AMPK: an emerging drug target for diabetes and the metabolic syndrome. , 2009, Cell metabolism.

[75]  P. Puigserver,et al.  AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity , 2009, Nature.

[76]  H. Matsuda,et al.  Medicinal flowers. XVI. New dammarane-type triterpene tetraglycosides and gastroprotective principles from flower buds of Panax ginseng. , 2007, Chemical & pharmaceutical bulletin.

[77]  Namjin Chung,et al.  Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ , 2004, Nature.

[78]  Tian-Shung Wu,et al.  Antityrosinase principles and constituents of the petals of Crocus sativus. , 2004, Journal of natural products.