Leukocyte integrin activation and deactivation: novel mechanisms of balancing inflammation

[1]  K. Ley,et al.  Rap1a activation by CalDAG‐GEFI and p38 MAPK is involved in E‐selectin‐dependent slow leukocyte rolling , 2011, European journal of immunology.

[2]  S. Butz,et al.  GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice , 2011, Nature Medicine.

[3]  Cheng Zhu,et al.  Rolling cell adhesion. , 2010, Annual review of cell and developmental biology.

[4]  K. Ley,et al.  PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils , 2022 .

[5]  K. Coggeshall,et al.  E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling. , 2010, Blood.

[6]  K. Ley,et al.  Tyrosine Kinase Btk Regulates E-selectin–mediated Integrin Activation and Neutrophil Recruitment by Controlling Phospholipase C (plc) ␥2 and Pi3k␥ Pathways Results the Tec Family Kinase Btk Is Required for E-selectin–mediated Slow Rolling and G␣ I -independent Adhesion, but Not for Chemokine-induced , 2022 .

[7]  K. Ley,et al.  PSGL‐1‐dependent myeloid leukocyte activation , 2009, Journal of leukocyte biology.

[8]  R. Fässler,et al.  The Tail of Integrins, Talin, and Kindlins , 2009, Science.

[9]  Cinzia Giagulli,et al.  Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module , 2009, Nature Immunology.

[10]  K. Ley,et al.  PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling , 2008, The Journal of experimental medicine.

[11]  D. Schmidtke,et al.  Separable requirements for cytoplasmic domain of PSGL-1 in leukocyte rolling and signaling under flow. , 2008, Blood.

[12]  M. Cybulsky,et al.  Getting to the site of inflammation: the leukocyte adhesion cascade updated , 2007, Nature Reviews Immunology.

[13]  R. Alon,et al.  Integrin modulation and signaling in leukocyte adhesion and migration , 2007, Immunological reviews.

[14]  C. Abram,et al.  Convergence of immunoreceptor and integrin signaling , 2007, Immunological reviews.

[15]  D. Vestweber.  Adhesion and signaling molecules controlling the transmigration of leukocytes through endothelium , 2007, Immunological reviews.

[16]  Gideon Rechavi,et al.  A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets , 2007, The Journal of experimental medicine.

[17]  K. Ley,et al.  Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1. , 2007, Immunity.

[18]  C. Carman,et al.  Structural basis of integrin regulation and signaling. , 2007, Annual review of immunology.

[19]  Hong Zhang,et al.  The Src Family Kinases Hck and Fgr Regulate Neutrophil Responses to N-Formyl-Methionyl-Leucyl-Phenylalanine1 , 2007, The Journal of Immunology.

[20]  K. Ley,et al.  Platelet-neutrophil-interactions: linking hemostasis and inflammation. , 2007, Blood reviews.

[21]  M. Cybulsky,et al.  Phospholipase C, calcium, and calmodulin are critical for alpha4beta1 integrin affinity up-regulation and monocyte arrest triggered by chemoattractants. , 2006, Blood.

[22]  K. Ley,et al.  Leukocyte phosphoinositide‐3 kinase γ is required for chemokine‐induced, sustained adhesion under flow in vivo , 2006, Journal of leukocyte biology.

[23]  Bryan Heit,et al.  Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade , 2006, The Journal of experimental medicine.

[24]  Cinzia Giagulli,et al.  The Src Family Kinases Hck and Fgr Are Dispensable for Inside-Out, Chemoattractant-Induced Signaling Regulating β2 Integrin Affinity and Valency in Neutrophils, but Are Required for β2 Integrin-Mediated Outside-In Signaling Involved in Sustained Adhesion1 , 2006, The Journal of Immunology.

[25]  M. Cybulsky,et al.  Phospholipase C, calcium and calmodulin are critical for α4β1 integrin affinity up‐regulation and monocyte arrest triggered by chemoattractants , 2006 .

[26]  G. Koretzky,et al.  SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond , 2006, Nature Reviews Immunology.

[27]  T. Kinashi,et al.  Intracellular signalling controlling integrin activation in lymphocytes , 2005, Nature Reviews Immunology.

[28]  T. Mayadas,et al.  Neutrophil β2 integrins: moderators of life or death decisions , 2005 .

[29]  D. Cantrell,et al.  Integrin Regulation by RhoA in Thymocytes1 , 2005, The Journal of Immunology.

[30]  V. Tybulewicz,et al.  Vav-family proteins in T-cell signalling. , 2005, Current opinion in immunology.

[31]  Waldemar Kolanus,et al.  Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines , 2005, Nature Immunology.

[32]  T. Mayadas,et al.  Neutrophil beta2 integrins: moderators of life or death decisions. , 2005, Trends in immunology.

[33]  Burkhart Schraven,et al.  Transmembrane adaptor proteins: organizers of immunoreceptor signalling , 2004, Nature Reviews Immunology.

[34]  A. Graybiel,et al.  CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation , 2004, Nature Medicine.

[35]  S. Jameson,et al.  Cutting Edge: LFA-1 Integrin-Dependent T Cell Adhesion Is Regulated by Both Ag Specificity and Sensitivity1 , 2004, The Journal of Immunology.

[36]  Burkhart Schraven,et al.  Transmembrane adaptor proteins: organizers of immunoreceptor signalling , 2004, Nature Reviews Immunology.

[37]  T. Mayadas,et al.  Vav GEFs are required for β2 integrin-dependent functions of neutrophils , 2004, The Journal of cell biology.

[38]  Minsoo Kim,et al.  Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins , 2003, Science.

[39]  E. Stoffel,et al.  Natalizumab for active Crohn's disease. , 2003, The New England journal of medicine.

[40]  Tomas Mustelin,et al.  Positive and negative regulation of T-cell activation through kinases and phosphatases. , 2003, The Biochemical journal.

[41]  Junichi Takagi,et al.  Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation , 2003, Cell.

[42]  David H. Miller,et al.  A controlled trial of natalizumab for relapsing multiple sclerosis. , 2003, The New England journal of medicine.

[43]  Richard O Hynes,et al.  Integrins Bidirectional, Allosteric Signaling Machines , 2002, Cell.

[44]  Junichi Takagi,et al.  Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling , 2002, Cell.

[45]  R. Salgia,et al.  A Fragment of Paxillin Binds the α4Integrin Cytoplasmic Domain (Tail) and Selectively Inhibits α4-Mediated Cell Migration* , 2002, The Journal of Biological Chemistry.

[46]  R. Salgia,et al.  A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration. , 2002, The Journal of biological chemistry.

[47]  S. Opal,et al.  Anti-inflammatory cytokines. , 2000, Chest.

[48]  Z. Ding,et al.  Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. , 1999, Journal of immunology.

[49]  C. Rudd,et al.  FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[50]  W. D. Fairlie,et al.  MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[51]  T. Springer,et al.  The alpha subunit cytoplasmic domain regulates the assembly and adhesiveness of integrin lymphocyte function-associated antigen-1. , 1997, Journal of immunology.

[52]  Timothy A. Springer,et al.  Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain , 1997 .

[53]  T. Springer.  Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[54]  M. Diamond,et al.  A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen , 1993, The Journal of cell biology.