Checking Consistency Between Expression Data and Large Scale Regulatory Networks: A Case Study

We proposed in previous articles a qualitative approach to check the compatibility between a model of interactions and gene expression data. The purpose of the present work is to validate this methodology on a real-size setting. We study the response of Escherichia coli regulatory network to nutritional stress, and compare it to publicly available DNA microarray experiments. We show how the incompatibilities we found reveal missing interactions in the network, as well as observations in contradiction with available literature.

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