Investigation of retinal blood flow in glaucoma patients by Doppler Fourier-domain optical coherence tomography

The measurement of ocular blood flow is important in studying the pathophysiology and treatment of several leading causes of blindness. A pilot study was performed to evaluate the total retinal blood flow in glaucoma patient using Fourier domain optical coherence tomography. For normal people, the measured total retinal flow was between 40.8 and 60.2 μl/minute. We found that eyes with glaucoma had decreased retinal blood flow and average flow veocity, while the venous cross sectional areas were essentially the same as normal. The decrease in blood flow was highly correlated with the severity of visual field loss.

[1]  Teresa C. Chen,et al.  In vivo dynamic human retinal blood flow imaging using ultra-high-speed spectral domain optical Doppler tomography , 2003 .

[2]  T. Hirose,et al.  Retinal blood flow and nerve fiber layer measurements in early-stage open-angle glaucoma. , 2008, American journal of ophthalmology.

[3]  J. Nelson,et al.  Characterization of fluid flow velocity by optical Doppler tomography. , 1995, Optics letters.

[4]  J. D. de Boer,et al.  Doppler standard deviation imaging for clinical monitoring of in vivo human skin blood flow. , 2000, Optics letters.

[5]  J. Izatt,et al.  Retinal blood flow measurement by circumpapillary Fourier domain Doppler optical coherence tomography. , 2008, Journal of biomedical optics.

[6]  J. Izatt,et al.  In vivo imaging of human retinal flow dynamics by color Doppler optical coherence tomography. , 2003, Archives of ophthalmology.

[7]  G T Feke,et al.  Blood flow in the normal human retina. , 1989, Investigative ophthalmology & visual science.

[8]  Maciej Wojtkowski,et al.  Real-time measurement of in vitro flow by Fourier-domain color Doppler optical coherence tomography. , 2004, Optics letters.

[9]  Richard B. Rosen,et al.  Retinal Blood Flow in the Normal Human Eye Using the Canon Laser Blood Flowmeter , 2002, Ophthalmic Research.

[10]  E. Stefánsson,et al.  The impact of ocular blood flow in glaucoma , 2002, Progress in Retinal and Eye Research.

[11]  J. Izatt,et al.  In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography. , 1997, Optics letters.

[12]  Xingde Li,et al.  Real-time in vivo blood-flow imaging by moving-scatterer-sensitive spectral-domain optical Doppler tomography. , 2006, Optics letters.

[13]  B L Petrig,et al.  Blood velocity and volumetric flow rate in human retinal vessels. , 1985, Investigative ophthalmology & visual science.

[14]  M. Nicolela,et al.  Color Doppler imaging in patients with asymmetric glaucoma and unilateral visual field loss. , 1996, American journal of ophthalmology.

[15]  Marcelo T. Nicolela,et al.  Scanning laser Doppler flowmeter study of retinal and optic disk blood flow in glaucomatous patients. , 1996, American journal of ophthalmology.

[16]  Joseph A Izatt,et al.  In vivo total retinal blood flow measurement by Fourier domain Doppler optical coherence tomography. , 2007, Journal of biomedical optics.

[17]  J. Izatt,et al.  Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography , 2009, British Journal of Ophthalmology.

[18]  T F Sherman,et al.  On connecting large vessels to small. The meaning of Murray's law , 1981, The Journal of general physiology.

[19]  A. Harris,et al.  Capillary density and retinal diameter measurements and their impact on altered retinal circulation in glaucoma: a digital fluorescein angiographic study , 2002, The British journal of ophthalmology.

[20]  Shuichi Makita,et al.  Quantitative retinal-blood flow measurement with three-dimensional vessel geometry determination using ultrahigh-resolution Doppler optical coherence angiography. , 2008, Optics letters.

[21]  Paul Mitchell,et al.  Retinal vessel diameter and open-angle glaucoma: the Blue Mountains Eye Study. , 2005, Ophthalmology.

[22]  J. Schuman,et al.  Optical coherence tomography. , 2000, Science.