Power supply for electronic contact lenses: Abiotic glucose fuel cells vs. Mg/air batteries

Abstract Electronic contact lenses are a promising platform for medical sensors. With these devices a variety of vital signs and medical parameters can be monitored noninvasively and without the risk of foreign body response. However, one current limitation of this technology is the need for an external power supply, resulting in bulky, multi component devices. In this paper, we for the first time investigate and compare the application of abiotic glucose fuel cells and Mg/air batteries as alternative power supply technologies for electronic contact lenses. While abiotic glucose fuel cells harvest energy from metabolites present in tear fluid, Mg/air batteries provide electricity by the oxidation of a sacrificial anode. Considering the space available on standard contact lenses, our results indicate that approx. 40 μW and 2 μW can be generated by Mg/air batteries and glucose fuel cells for a period of at least 24 h, respectively. However, coating galvanic cells with the commonly used contact lens material pHEMA, results in drastically reduced performance, presumably due to hindered mass transport. Nevertheless, even under those circumstances a Mg/air battery can still provide about 7 μW for 24 h, which would already be sufficient for many electronic contact lens applications.

[1]  R. Zengerle,et al.  Electrodeposited thin-layer electrodes for the use in potentially implantable glucose fuel cells , 2009, TRANSDUCERS 2009 - 2009 International Solid-State Sensors, Actuators and Microsystems Conference.

[2]  S. Kerzenmacher Abiotic (Nonenzymatic) Implantable Biofuel Cells , 2014 .

[3]  Justin T. Baca,et al.  Tear glucose analysis for the noninvasive detection and monitoring of diabetes mellitus. , 2007, The ocular surface.

[4]  Huanfen Yao,et al.  A contact lens with embedded sensor for monitoring tear glucose level. , 2011, Biosensors & bioelectronics.

[5]  M. Doble,et al.  In vitro and in vivo studies of biodegradable fine grained AZ31 magnesium alloy produced by equal channel angular pressing. , 2016, Materials science & engineering. C, Materials for biological applications.

[6]  R. Zengerle,et al.  Poisoning of Highly Porous Platinum Electrodes by Amino Acids and Tissue Fluid Constituents , 2015 .

[7]  Jun Chen,et al.  Magnesium–air batteries: from principle to application , 2014 .

[8]  S. Madhumathi,et al.  Tear fluid small molecular antioxidants profiling shows lowered glutathione in keratoconus. , 2012, Experimental eye research.

[9]  Guozhen Chen,et al.  Capacitive contact lens sensor for continuous non-invasive intraocular pressure monitoring , 2013 .

[10]  S. Asher,et al.  Photonic crystal glucose-sensing material for noninvasive monitoring of glucose in tear fluid. , 2004, Clinical chemistry.

[11]  R. Sarpeshkar,et al.  A Glucose Fuel Cell for Implantable Brain–Machine Interfaces , 2012, PloS one.

[12]  R. Zengerle,et al.  Fabrication of highly porous platinum electrodes for micro-scale applications by pulsed electrodeposition and dealloying , 2013 .

[13]  R. Zengerle,et al.  A potentially implantable glucose fuel cell with Raney-platinum film electrodes for improved hydrolytic and oxidative stability , 2011 .

[14]  D K Sen,et al.  Tear glucose levels in normal people and in diabetic patients. , 1980, The British journal of ophthalmology.

[15]  Andrés Vásquez Quintero,et al.  An active artificial iris controlled by a 25-μW flexible thin-film driver , 2016, 2016 IEEE International Electron Devices Meeting (IEDM).

[16]  T. Provder,et al.  Using DC electrochemical techniques to assess the relative corrosiveness of water-based coatings and their ingredients , 2007 .

[17]  Xinxin Xiao,et al.  Nanoporous Gold-Based Biofuel Cells on Contact Lenses. , 2018, ACS applied materials & interfaces.

[18]  N. J. van Haeringen,et al.  Collection method dependant concentrations of some metabolites in human tear fluid, with special reference to glucose in hyperglycaemic conditions , 1977, Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie.

[19]  Babak A. Parviz,et al.  A contact lens with integrated micro solar cells , 2012 .

[20]  Shelley D Minteer,et al.  Contact lens biofuel cell tested in a synthetic tear solution. , 2015, Biosensors & bioelectronics.

[21]  R. Zengerle,et al.  Cyclic Electrodeposition of PtCu Alloy: Facile Fabrication of Highly Porous Platinum Electrodes , 2012, Advanced materials.

[22]  B. Parviz,et al.  Contact lens with integrated inorganic semiconductor devices , 2008, 2008 IEEE 21st International Conference on Micro Electro Mechanical Systems.

[23]  R. Villa,et al.  Prototype of a nanostructured sensing contact lens for noninvasive intraocular pressure monitoring. , 2011, Investigative ophthalmology & visual science.

[24]  E. Han,et al.  Corrosion resistance of Mg-Al-LDH coating on magnesium alloy AZ31 , 2014 .

[25]  L. Ren,et al.  Fabrication of a superhydrophobic graphene surface with excellent mechanical abrasion and corrosion resistance on an aluminum alloy substrate , 2014 .

[26]  W. March,et al.  Fluorescent measurement in the non-invasive contact lens glucose sensor. , 2006, Diabetes technology & therapeutics.

[27]  André Mermoud,et al.  Wireless contact lens sensor for intraocular pressure monitoring: assessment on enucleated pig eyes , 2009, Acta ophthalmologica.

[28]  G. Richter,et al.  Implantable bio-electrochemical power sources , 1974, Naturwissenschaften.

[29]  Kohji Mitsubayashi Novel biosensing devices for medical applications Soft contact-lens sensors for monitoring tear sugar , 2014, 2014 International Conference on Simulation of Semiconductor Processes and Devices (SISPAD).

[30]  P Cho,et al.  Water-soluble antioxidants in human tears: effect of the collection method. , 2001, Investigative ophthalmology & visual science.

[31]  Christel Ps Biocompatibility of surgical-grade dense polycrystalline alumina. , 1992 .

[32]  Yingwei Song,et al.  Biodegradable behaviors of AZ31 magnesium alloy in simulated body fluid , 2009 .

[33]  Dmitry Pankratov,et al.  Transparent and flexible, nanostructured and mediatorless glucose/oxygen enzymatic fuel cells , 2015 .

[34]  D. Sen,et al.  Immunoglobulin concentrations in human tears in ocular diseases. , 1979, The British journal of ophthalmology.

[35]  P. Petrov,et al.  Protective coating of zinc and zinc alloys for industrial applications , 2006 .

[36]  Y. Jung,et al.  3D Cross‐Point Plasmonic Nanoarchitectures Containing Dense and Regular Hot Spots for Surface‐Enhanced Raman Spectroscopy Analysis , 2016, Advanced materials.

[37]  Joseph R. Lakowicz,et al.  A Glucose Sensing Contact Lens: A Non-Invasive Technique for Continuous Physiological Glucose Monitoring , 2003, Journal of Fluorescence.

[38]  W. Müller,et al.  Magnesium and its Alloys as Degradable Biomaterials. Corrosion Studies Using Potentiodynamic and EIS Electrochemical Techniques , 2007 .

[39]  Yu-Te Liao,et al.  A single-pixel wireless contact lens display , 2011, Journal of Micromechanics and Microengineering.

[40]  R. Zengerle,et al.  Performance Loss of a Pt‐Based Implantable Glucose Fuel Cell in Simulated Tissue and Cerebrospinal Fluids , 2014 .

[41]  M. Escudero,et al.  Corrosion behaviour of AZ31 magnesium alloy with different grain sizes in simulated biological fluids. , 2010, Acta biomaterialia.

[42]  Feng Zhao,et al.  Metallic zinc exhibits optimal biocompatibility for bioabsorbable endovascular stents. , 2015, Materials science & engineering. C, Materials for biological applications.

[43]  A. Bright,et al.  The composition and interfacial properties of tears, tear substitutes and tear models , 1993 .

[44]  Roland Zengerle,et al.  Raney-platinum film electrodes for potentially implantable glucose fuel cells. Part 2: Glucose-tolerant oxygen reduction cathodes , 2010 .

[45]  Diego Mantovani,et al.  Biodegradable Metals for Cardiovascular Stent Application: Interests and New Opportunities , 2011, International journal of molecular sciences.

[46]  David Blaauw,et al.  A cubic-millimeter energy-autonomous wireless intraocular pressure monitor , 2011, 2011 IEEE International Solid-State Circuits Conference.

[47]  Justin T. Baca,et al.  Analysis of tear glucose concentration with electrospray ionization mass spectrometry , 2007, Journal of the American Society for Mass Spectrometry.

[48]  O. Petrii,et al.  Real surface area measurements in electrochemistry , 1991 .

[49]  Roland Zengerle,et al.  A complete testing environment for the automated parallel performance characterization of biofuel cells: design, validation, and application , 2009 .

[50]  Alexis M Pietak,et al.  Magnesium and its alloys as orthopedic biomaterials: a review. , 2006, Biomaterials.

[51]  P. Griffith,et al.  Holographic sensors in contact lenses for minimally-invasive glucose measurements , 2004, Proceedings of IEEE Sensors, 2004..

[52]  R. Zengerle,et al.  Porous Platinum Electrodes Fabricated by Cyclic Electrodeposition of PtCu Alloy: Application to Implantable Glucose Fuel Cells , 2012 .

[53]  Sergey Shleev,et al.  Biofuel cell as a power source for electronic contact lenses. , 2012, Biosensors & bioelectronics.

[54]  J. Blyth,et al.  Glucose‐sensitive holographic sensors , 2004, Journal of molecular recognition : JMR.

[55]  Jing Zhang,et al.  Electrochemical behavior of biocompatible AZ31 magnesium alloy in simulated body fluid , 2012, Journal of Materials Science.

[56]  Shelley D Minteer,et al.  Biofuel cells: enhanced enzymatic bioelectrocatalysis. , 2012, Annual review of analytical chemistry.

[57]  P Cho,et al.  Ascorbic acid concentration and total antioxidant activity of human tear fluid measured using the FRASC assay. , 2000, Investigative ophthalmology & visual science.

[58]  P. Christel Biocompatibility of surgical-grade dense polycrystalline alumina. , 1992, Clinical orthopaedics and related research.

[59]  A. Afanasiev,et al.  A soft hydrogel contact lens with an encapsulated sensor for tear glucose monitoring , 2012, 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems (MEMS).

[60]  David P. Hickey,et al.  Modeling Carbon Nanotube Connectivity and Surface Activity in a Contact Lens Biofuel Cell , 2016 .

[61]  S. Richer,et al.  Tear fluid content of electrochemically active components including water soluble antioxidants. , 1998, Current eye research.

[62]  M H Osman,et al.  Recent progress and continuing challenges in bio-fuel cells. Part I: enzymatic cells. , 2011, Biosensors & bioelectronics.

[63]  Mark G. Allen,et al.  Biodegradable magnesium/iron batteries with polycaprolactone encapsulation: A microfabricated power source for transient implantable devices , 2015, Microsystems & Nanoengineering.

[64]  Babak A. Parviz,et al.  A contact lens with an integrated lactate sensor , 2012 .

[65]  Roland Zengerle,et al.  Energy harvesting by implantable abiotically catalyzed glucose fuel cells , 2008 .

[66]  Roland Zengerle,et al.  Nanofiber-deposited porous platinum enables glucose fuel cell anodes with high current density in body fluids , 2017 .

[67]  A. Afanasiev,et al.  A dual microscale glucose sensor on a contact lens, tested in conditions mimicking the eye , 2011, 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems.

[68]  Shigeru Kinoshita,et al.  Amino Acid profiles in human tear fluids analyzed by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry. , 2011, American journal of ophthalmology.

[69]  Sergey Shleev,et al.  Miniature biofuel cell as a potential power source for glucose-sensing contact lenses. , 2013, Analytical chemistry.

[70]  Dermot Diamond,et al.  Glucose Sensing for Diabetes Monitoring: Recent Developments , 2017, Sensors.

[71]  Seok Hyun Yun,et al.  Contact Lens Sensors in Ocular Diagnostics , 2015, Advanced healthcare materials.

[72]  Yu-Te Liao,et al.  A 3-$\mu\hbox{W}$ CMOS Glucose Sensor for Wireless Contact-Lens Tear Glucose Monitoring , 2012, IEEE Journal of Solid-State Circuits.

[73]  Raj Solanki,et al.  Fabrication, characterization, and modeling of a biodegradable battery for transient electronics , 2016 .

[74]  R M Hill,et al.  Human tear glucose. , 1982, Investigative ophthalmology & visual science.