Mediators of Ischemic Renal Injury

Acute renal failure is a serious consequence of renal ischemia. The diagnosis carries an associated high mortality rate. When blood flow to the kidneys is inadequate to supply metabolic demands, a number of pathophysiological changes occur that ultimately result in cell death and tissue dysfunction, characterized by a marked reduction in glomerular filtration rate and associated accumulation of systemic toxins and disorders of fluid and electrolyte metabolism. In this chapter we review the factors that have been implicated as mediators of the renal tissue damage associated with ischemia and reperfusion.

[1]  R. Schrier,et al.  Beneficial effects of calcium channel blockers and calmodulin binding drugs on in vitro renal cell anoxia. , 1986, The Journal of pharmacology and experimental therapeutics.

[2]  S. Lemeshow,et al.  Role of membrane phospholipids in myocardial injury induced by ischemia and reperfusion. , 1986, The American journal of physiology.

[3]  Roger Y. Tsien,et al.  Changes of free calcium levels with stages of the cell division cycle , 1985, Nature.

[4]  A. Borle,et al.  The effects of anoxia on cytosolic free calcium, calcium fluxes, and cellular ATP levels in cultured kidney cells. , 1985, The Journal of biological chemistry.

[5]  J. Cheung,et al.  Effects of metabolic acidosis on viability of cells exposed to anoxia. , 1985, The American journal of physiology.

[6]  I. Fridovich,et al.  Increased superoxide radical production evokes inducible DNA repair in Escherichia coli. , 1985, The Journal of biological chemistry.

[7]  M. Hess,et al.  Neutrophil-derived, oxygen free radical-mediated cardiovascular dysfunction. , 1984, Journal of molecular and cellular cardiology.

[8]  T. Ferris,et al.  Oxygen free radicals in ischemic acute renal failure in the rat. , 1984, The Journal of clinical investigation.

[9]  J. Kreisberg,et al.  Lipid alterations induced by renal ischemia: pathogenic factor in membrane damage. , 1984, Kidney international.

[10]  R. Schrier,et al.  Mitochondrial calcium accumulation and respiration in ischemic acute renal failure in the rat. , 1984, Kidney international.

[11]  J. Cheung,et al.  Effects of verapamil in models of ischemic acute renal failure in the rat. , 1983, The American journal of physiology.

[12]  G. Eknoyan,et al.  Endothelial characteristics of glomerular capillaries in normal, mercuric chloride-induced, and gentamicin-induced acute renal failure in the rat. , 1983, The Journal of clinical investigation.

[13]  J. McCord,et al.  The pathophysiology of superoxide: roles in inflammation and ischemia. , 1982, Canadian journal of physiology and pharmacology.

[14]  N. Dhalla,et al.  Role of free radicals in catecholamine-induced cardiomyopathy. , 1982, Canadian journal of physiology and pharmacology.

[15]  J. Cheung,et al.  Effects of extracellular calcium removal and anoxia on isolated rat myocytes. , 1982, The American journal of physiology.

[16]  I. Chaudry,et al.  Accelerated recovery of single nephron function by the postischemic infusion of ATP-MgCl2. , 1982, Kidney international.

[17]  R. Jennings,et al.  Total Ischemia in Dog Hearts, in Vitro: 1. Comparison of High Energy Phosphate Production, Utilization, and Depletion, and of Adenine Nucleotide Catabolism in Total Ischemia in Vitro vs. Severe Ischemia in Vivo , 1981, Circulation research.

[18]  A. Evan,et al.  Hemodynamic and single nephron function during the maintenance phase of ischemic acute renal failure in the dog. , 1981, Kidney international.

[19]  S. Guggenheim,et al.  Effect of acetylcholine on the early phase of reversible norepinephrine-induced acute renal failure. , 1981, Kidney international.

[20]  L. Navar,et al.  Impaired renal blood flow autoregulation in ischemic acute renal failure. , 1980, Kidney international.

[21]  I. Chaudry,et al.  Enhanced recovery from acute renal failure by the postischemic infusin of adenine nucleotides and magnesium chloride in rats. , 1980, Kidney international.

[22]  J. Farber,et al.  Calcium dependence of toxic cell death: a final common pathway. , 1979, Science.

[23]  A. Campbell,et al.  Rapid increase in intracellular free Ca2+ induced by antibody plus complement , 1979, FEBS letters.

[24]  T. Stossel,et al.  Control of cytoplasmic actin gel–sol transformation by gelsolin, a calcium-dependent regulatory protein , 1979, Nature.

[25]  J. Farber,et al.  Accelerated phospholipid degradation and associated membrane dysfunction in irreversible, ischemic liver cell injury. , 1978, The Journal of biological chemistry.

[26]  M. Venkatachalam,et al.  Ischemic damage and repair in the rat proximal tubule: differences among the S1, S2, and S3 segments. , 1978, Kidney international.

[27]  J. Lowe,et al.  Relation between high energy phosphate and lethal injury in myocardial ischemia in the dog. , 1978, The American journal of pathology.

[28]  S. Chan,et al.  Uncoupling activity of endogenous free fatty acids in rat liver mitochondria. , 1978, Canadian journal of biochemistry.

[29]  E. Kemp,et al.  Inosine in preservation of rabbit kidneys for transplantation. , 1977, Transplantation proceedings.

[30]  J. Wickham,et al.  Protective effect of inosine on the canine kidney during ischaemia at 37 C. , 1977, Transplantation.

[31]  J. Wickham,et al.  ENHANCED PRESERVATION OF THE ISCHÆMIC KIDNEY WITH INOSINE , 1976, The Lancet.

[32]  B. Safer,et al.  Contribution of tissue acidosis to ischemic injury in the perfused rat heart. , 1976, Circulation.

[33]  K. Rajagopalan,et al.  Purification and properties of the NAD+-dependent (type D) and O2-dependent (type O) forms of rat liver xanthine dehydrogenase. , 1976, Archives of biochemistry and biophysics.

[34]  C. W. Gottschalk,et al.  Pathogenesis of Acute Renal Failure following Temporary Renal Ischemia in the Rat , 1975, Circulation research.

[35]  A. Lamola,et al.  REACTIVITY OF CHOLESTEROL AND SOME FATTY ACIDS TOWARD SINGLET OXYGEN , 1974, Photochemistry and photobiology.

[36]  B. Trump,et al.  Extracellular Acidosis Protects Ehrlich Ascites Tumor Cells and Rat Renal Cortex against Anoxic Injury , 1974, Science.

[37]  R. Coleman.  Membrane-bound enzymes and membrane ultrastructure. , 1973, Biochimica et biophysica acta.

[38]  R C Weisenberg,et al.  Microtubule Formation in vitro in Solutions Containing Low Calcium Concentrations , 1972, Science.

[39]  J. L. Mego,et al.  An adenosine triphosphate-dependent stabilization of proteolytic activity in heterolysosomes. Evidence for a proton pump. , 1972, The Biochemical journal.

[40]  R. Jennings,et al.  Alterations in renal cortex following ischemic injury. 3. Ultrastructure of proximal tubules after ischemia or autolysis. , 1972, Laboratory investigation; a journal of technical methods and pathology.

[41]  L. Hart,et al.  Effect of adenosine triphosphate and some anti-inflammatory agents on a purified lysosomal fraction having high acid phosphatase and labile -glucuronidase activity. , 1971, Biochemical pharmacology.

[42]  R. Egdahl,et al.  pH Dependent Changes in Cell Membrane Stability , 1971, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[43]  J. Brosnan,et al.  Effects of ischaemia on content of metabolites in rat liver and kidney in vivo. , 1970, The Biochemical journal.

[44]  R. Kessler.  Effects of Ischemia on the Concentration of Adenine Nucleotides in the Kidney of Anesthetized Dogs 1 , 1970, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[45]  A. Hodgkin,et al.  The influence of calcium on sodium efflux in squid axons , 1969, The Journal of physiology.

[46]  N. Hollenberg,et al.  ACUTE OLIGURIC RENAL FAILURE IN MAN: EVIDENCE FOR PREFERENTIAL RENAL CORTICAL ISCHEMIA , 1968, Medicine.

[47]  J. Oliver,et al.  The pathogenesis of acute renal failure associated with traumatic and toxic injury; renal ischemia, nephrotoxic damage and the ischemic episode. , 1951, The Journal of clinical investigation.

[48]  J. Cheung,et al.  Mitochondrial function and intracellular calcium in anoxic cardiac myocytes. , 1986, The American journal of physiology.

[49]  Y. Vladimirov,et al.  Lipid peroxidation in mitochondrial membrane. , 1980, Advances in lipid research.

[50]  R. Casali,et al.  Effect of inosine on warm renal ischemia in monkeys and dogs. , 1979, Surgical forum.

[51]  I. Hägerstrand,et al.  Adenosine: in preservation of rabbit kidneys. , 1978, Acta medica Polona.

[52]  A. Leaf,et al.  The role of cell swelling in ischemic renal damage and the protective effect of hypertonic solute. , 1972, The Journal of clinical investigation.