Regulation of NLRP3 by non-coding RNAs in different cancers: interplay between non-coding RNAs and NLRP3 in carcinogenesis and metastasis.

NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasomes are multitasking intracellular sensors having characteristically unique ability to detect myriad of microbial motifs and endogenous danger signals which promote structural assembly of NLRP3 inflammasome thus enabling it to perform instrumental roles. Detailed mechanistic insights revealed that molecularly assembled NLRP3 inflammasomes stimulated caspase-1-driven release of the pro-inflammatory cytokines. NLRP3 has been shown to play fundamental role in the regulation of cancer progression and metastasis. Recently emerging cutting-edge research-works have started to shed light on the involvement of non-coding RNAs in the regulation of NLRP3 in different cancers. MicroRNAs, lncRNAs and circular RNAs have been shown to modulate NLRP3 in different diseases. However, we still have incomplete information about regulation of NLRP3 by circular RNAs in various cancers. In this review, we will comprehensively analyze how different microRNAs and long non-coding RNAs modulate NLRP3 in human cancers. Emerging evidence has started to scratch the surface of the participation of miRNAs and lncRNAs in the regulation of NLRP3. Xenografted mice-based studies have also enabled us to develop a better comprehension of interplay between miRNAs, lncRNAs and NLRP3. Hopefully, detailed analysis of contextual regulation of NLRP3 by oncogenic and tumor suppressor miRNAs, lncRNAs and circRNAs will be helpful in getting a step closer to the personalized medicine.

[1]  Wenying Zhao,et al.  Cancer-derived exosomal TRIM59 regulates macrophage NLRP3 inflammasome activation to promote lung cancer progression , 2020, Journal of experimental & clinical cancer research : CR.

[2]  Hong Zhang,et al.  miR-22 Suppresses Tumor Invasion and Metastasis in Colorectal Cancer by Targeting NLRP3 , 2020, Cancer management and research.

[3]  Q. Wang,et al.  miR-22 suppresses cell viability and EMT of ovarian cancer cells via NLRP3 and inhibits PI3K/AKT signaling pathway , 2020, Clinical and Translational Oncology.

[4]  D. Piao,et al.  LncRNA ADAMTS9-AS2 inhibits gastric cancer (GC) development and sensitizes chemoresistant GC cells to cisplatin by regulating miR-223-3p/NLRP3 axis , 2020, Aging.

[5]  G. Kroemer,et al.  Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity , 2020, Nature Cell Biology.

[6]  Luo Zhao,et al.  Silencing of lncRNA XIST inhibits non-small cell lung cancer growth and promotes chemosensitivity to cisplatin , 2020, Aging.

[7]  D. Bar-Sagi,et al.  Tumor Cell-Derived IL-1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer. , 2020, Cancer research.

[8]  Zhenxing Xu,et al.  LncRNA RGMB-AS1 promotes laryngeal squamous cell carcinoma cells progression via sponging miR-22/NLRP3 axis. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[9]  N. Erez,et al.  NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis , 2019, Nature Communications.

[10]  L. Yao,et al.  Downregulation of LncRNA-XIST inhibited development of non-small cell lung cancer by activating miR-335/SOD2/ROS signal pathway mediated pyroptotic cell death , 2019, Aging.

[11]  Chun-you Wang,et al.  LncRNA differentiation antagonizing non-protein coding RNA promotes proliferation and invasion through regulating miR-135a/NLRP37 axis in pancreatic cancer , 2019, Investigational New Drugs.

[12]  J. Pais de Barros,et al.  Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNK-mediated mature IL-1β secretion in 5-fluorouracil-treated MDSC: implication in cancer treatment , 2019, Cell Death & Disease.

[13]  C. Day,et al.  MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition , 2019, Nature Chemical Biology.

[14]  Horacio Pérez-Sánchez,et al.  MCC950 closes the active conformation of NLRP3 to an inactive state , 2019, Nature Chemical Biology.

[15]  T. Kanneganti,et al.  Diverging inflammasome signals in tumorigenesis and potential targeting , 2019, Nature Reviews Cancer.

[16]  Q. Cao,et al.  LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma , 2019, Cell Death & Disease.

[17]  Q. Ma,et al.  NLRP3 inflammasomes in macrophages drive colorectal cancer metastasis to the liver. , 2019, Cancer letters.

[18]  Liping Zhang,et al.  NLRP3 inflammasome inactivation driven by miR-223-3p reduces tumor growth and increases anticancer immunity in breast cancer , 2019, Molecular medicine reports.

[19]  Xiaodong Feng,et al.  MicroRNA‐22 suppresses cell proliferation, migration and invasion in oral squamous cell carcinoma by targeting NLRP3 , 2018, Journal of cellular physiology.

[20]  A. Yan,et al.  MiR-223-3p overexpression inhibits cell proliferation and migration by regulating inflammation-associated cytokines in glioblastomas. , 2018, Pathology, research and practice.

[21]  X. Liang,et al.  MiR-22 sustains NLRP3 expression and attenuates H. pylori-induced gastric carcinogenesis , 2018, Oncogene.

[22]  Y. Miao,et al.  Long non-coding RNA XLOC_000647 suppresses progression of pancreatic cancer and decreases epithelial-mesenchymal transition-induced cell invasion by down-regulating NLRP3 , 2018, Molecular Cancer.

[23]  Bo-yu Xue,et al.  miRNA-223-3p regulates NLRP3 to promote apoptosis and inhibit proliferation of hep3B cells , 2017, Experimental and therapeutic medicine.

[24]  R. Savai,et al.  S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β , 2017, The Journal of experimental medicine.

[25]  Lei Wu,et al.  NLRP3 inflammasome activation promotes inflammation-induced carcinogenesis in head and neck squamous cell carcinoma , 2017, Journal of experimental & clinical cancer research : CR.

[26]  Xiaodong Feng,et al.  The role of NLRP3 inflammasome in 5-fluorouracil resistance of oral squamous cell carcinoma , 2017, Journal of experimental & clinical cancer research : CR.

[27]  N. Beauchemin,et al.  The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity. , 2015, Immunity.

[28]  Wilfrid Boireau,et al.  Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth , 2012, Nature Medicine.

[29]  L. Zitvogel,et al.  Inflammasomes in carcinogenesis and anticancer immune responses , 2012, Nature Immunology.