Tumor therapeutics by design: targeting and activation of death receptors.
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[1] S. Shankar,et al. Effects of sequential treatments with chemotherapeutic drugs followed by TRAIL on prostate cancer in vitro and in vivo , 2005, The Prostate.
[2] Wei Wei,et al. Synergistic antitumor activity of TRAIL combined with chemotherapeutic agents in A549 cell lines in vitro and in vivo , 2005, Cancer Chemotherapy and Pharmacology.
[3] Karen Billeci,et al. Receptor-selective Mutants of Apoptosis-inducing Ligand 2/Tumor Necrosis Factor-related Apoptosis-inducing Ligand Reveal a Greater Contribution of Death Receptor (DR) 5 than DR4 to Apoptosis Signaling* , 2005, Journal of Biological Chemistry.
[4] M. Peter,et al. Induction of apoptosis and activation of NF‐κB by CD95 require different signalling thresholds , 2004, EMBO reports.
[5] N. Fusenig,et al. Friends or foes — bipolar effects of the tumour stroma in cancer , 2004, Nature Reviews Cancer.
[6] A. Corti,et al. Crucial Role for Interferon γ in the Synergism between Tumor Vasculature-Targeted Tumor Necrosis Factor α (NGR-TNF) and Doxorubicin , 2004, Cancer Research.
[7] S. Shankar,et al. Ionizing radiation enhances the therapeutic potential of TRAIL in prostate cancer in vitro and in vivo: Intracellular mechanisms , 2004, The Prostate.
[8] D. Kabelitz,et al. Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles. , 2004, Immunity.
[9] D. Lawrence,et al. Apo2 Ligand/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Cooperates with Chemotherapy to Inhibit Orthotopic Lung Tumor Growth and Improve Survival , 2004, Cancer Research.
[10] Hong Cheng,et al. Primary targeting of recombinant Fv-immunotoxin hscFv25-mTNFα against hepatocellular carcinoma , 2004 .
[11] P. Pour,et al. The Combination of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (TRAIL/Apo2L) and Genistein Is Effective in Inhibiting Pancreatic Cancer Growth , 2004, Pancreas.
[12] S. Shankar,et al. The sequential treatment with ionizing radiation followed by TRAIL/Apo-2L reduces tumor growth and induces apoptosis of breast tumor xenografts in nude mice. , 2004, International journal of oncology.
[13] P. Vandenabeele,et al. Toxic proteins released from mitochondria in cell death , 2004, Oncogene.
[14] P. Sova,et al. A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases. , 2004, Molecular therapy : the journal of the American Society of Gene Therapy.
[15] H. Walczak,et al. Target cell‐restricted and ‐enhanced apoptosis induction by a scFv:sTRAIL fusion protein with specificity for the pancarcinoma‐associated antigen EGP2 , 2004, International journal of cancer.
[16] Yasuo Yoshioka,et al. Optimal site-specific PEGylation of mutant TNF-α improves its antitumor potency , 2004 .
[17] A. Scott,et al. Targeted Bioactivity of Membrane-Anchored TNF by an Antibody-Derived TNF Fusion Protein1 , 2004, The Journal of Immunology.
[18] T. Sayers,et al. Induction of Tumor-specific T Cell Immunity by Anti-DR5 Antibody Therapy , 2004, The Journal of experimental medicine.
[19] M. Rosenblum,et al. Recombinant single‐chain antibody fusion construct targeting human melanoma cells and containing tumor necrosis factor , 2004, International journal of cancer.
[20] R. Longhi,et al. Coupling Tumor Necrosis Factor-α with αV Integrin Ligands Improves Its Antineoplastic Activity , 2004, Cancer Research.
[21] S. Lowe,et al. Control of apoptosis by p53 , 2003, Oncogene.
[22] Suzanne Cory,et al. The Bcl-2 family: roles in cell survival and oncogenesis , 2003, Oncogene.
[23] J. Roth,et al. Current status of gene therapy for lung cancer and head and neck cancer. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[24] E. Borden,et al. Suppression of NF-κB Survival Signaling by Nitrosylcobalamin Sensitizes Neoplasms to the Anti-tumor Effects of Apo2L/TRAIL* , 2003, Journal of Biological Chemistry.
[25] P. Caliceti,et al. Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates. , 2003, Advanced drug delivery reviews.
[26] S. Shankar,et al. Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo. , 2003, Cancer research.
[27] M. Xiong,et al. Combination of TRAIL gene therapy and chemotherapy enhances antitumor and antimetastasis effects in chemosensitive and chemoresistant breast cancers. , 2003, Molecular therapy : the journal of the American Society of Gene Therapy.
[28] H. Wajant,et al. Generation of a FasL-based Proapoptotic Fusion Protein Devoid of Systemic Toxicity due to Cell-surface Antigen-restricted Activation* , 2003, Journal of Biological Chemistry.
[29] S. Ray,et al. Apoptosis induction in prostate cancer cells and xenografts by combined treatment with Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand and CPT-11. , 2003, Cancer research.
[30] J. Tschopp,et al. Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes , 2003, Cell.
[31] A. Eggermont,et al. Current uses of isolated limb perfusion in the clinic and a model system for new strategies. , 2003, The Lancet. Oncology.
[32] Dario Neri,et al. Synergistic therapeutic effects of a tumor targeting antibody fragment, fused to interleukin 12 and to tumor necrosis factor alpha. , 2003, Cancer research.
[33] M. Tykocinski,et al. CTLA-4 · FasL Induces Alloantigen-Specific Hyporesponsiveness1 , 2003, The Journal of Immunology.
[34] A. Ashkenazi,et al. Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy. , 2003, Cytokine & growth factor reviews.
[35] Martin Schenk,et al. Adenoviral gene transfer of tumor necrosis factor-related apoptosis-inducing ligand overcomes an impaired response of hepatoma cells but causes severe apoptosis in primary human hepatocytes. , 2003, Cancer research.
[36] D. Vaux,et al. Mammalian mitochondrial IAP binding proteins. , 2003, Biochemical and biophysical research communications.
[37] Yasuo Yoshioka,et al. Site-specific PEGylation of a lysine-deficient TNF-α with full bioactivity , 2003, Nature Biotechnology.
[38] S. Larson,et al. A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[39] Jeffrey M. Vinocur,et al. LETAL, A Tumor-Associated NKG2D Immunoreceptor Ligand, Induces Activation and Expansion of Effector Immune Cells , 2003, Cancer biology & therapy.
[40] Pascal Schneider,et al. Two Adjacent Trimeric Fas Ligands Are Required for Fas Signaling and Formation of a Death-Inducing Signaling Complex , 2003, Molecular and Cellular Biology.
[41] Klaus Pfizenmaier,et al. Non-apoptotic Fas signaling. , 2003, Cytokine & growth factor reviews.
[42] C. Briand,et al. Insights into the regulatory mechanism for caspase-8 activation. , 2003, Molecular cell.
[43] D. Green,et al. A unified model for apical caspase activation. , 2003, Molecular cell.
[44] E. Bröcker,et al. Proteasome Inhibition Results in TRAIL Sensitization of Primary Keratinocytes by Removing the Resistance-Mediating Block of Effector Caspase Maturation , 2003, Molecular and Cellular Biology.
[45] S. Xiao,et al. A Novel Signaling Mechanism for Soluble CD95 Ligand , 2002, The Journal of Biological Chemistry.
[46] L. Khawli,et al. Generation of human interferon gamma and tumor Necrosis factor alpha chimeric TNT-3 fusion proteins. , 2002, Hybridoma and hybridomics.
[47] M. Xiong,et al. Long-term tumor-free survival from treatment with the GFP–TRAIL fusion gene expressed from the hTERT promoter in breast cancer cells , 2002, Oncogene.
[48] Kazuyoshi Takeda,et al. New aspects of natural-killer-cell surveillance and therapy of cancer , 2002, Nature Reviews Cancer.
[49] S. Ferrone,et al. Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity. , 2002, Cancer research.
[50] P. Robbins,et al. Effective treatment of established mouse collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express FasL. , 2002, Molecular therapy : the journal of the American Society of Gene Therapy.
[51] Y. Rustum,et al. Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice. , 2002, Cancer research.
[52] P. Scheurich,et al. TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy , 2002, Apoptosis.
[53] G. Screaton,et al. Fas ligand breaks tolerance to self-antigens and induces tumor immunity mediated by antibodies. , 2002, Cancer cell.
[54] T. Allen. Ligand-targeted therapeutics in anticancer therapy , 2002, Nature Reviews Cancer.
[55] S. Libutti,et al. Induction of permeability across endothelial cell monolayers by tumor necrosis factor (TNF) occurs via a tissue factor-dependent mechanism: relationship between the procoagulant and permeability effects of TNF. , 2002, Blood.
[56] Angelo Corti,et al. Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration. , 2002, The Journal of clinical investigation.
[57] Steven A Curley,et al. Targeted expression of green fluorescent protein/tumor necrosis factor-related apoptosis-inducing ligand fusion protein from human telomerase reverse transcriptase promoter elicits antitumor activity without toxic effects on primary human hepatocytes. , 2002, Cancer research.
[58] K. Pfizenmaier,et al. TNF-Selectokine: a novel prodrug generated for tumor targeting and site-specific activation of tumor necrosis factor , 2002, Oncogene.
[59] R. Begent,et al. In vivo tumor delivery of a recombinant single chain fv :: tumor necrosis factor-alpha fusion protein (vol 13, pg 7, 2002) , 2002 .
[60] Yigong Shi. Apoptosome: the cellular engine for the activation of caspase-9. , 2002, Structure.
[61] R. Coffey,et al. Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[62] S. de Jong,et al. Fas receptor‐mediated apoptosis: a clinical application? , 2002, The Journal of pathology.
[63] J. Norris,et al. Resistance of prostate cancer cells to soluble TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) can be overcome by doxorubicin or adenoviral delivery of full-length TRAIL , 2002, Cancer Gene Therapy.
[64] M. Smyth,et al. Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development , 2002, The Journal of experimental medicine.
[65] F. Fan,et al. A complex adenovirus vector that delivers FASL-GFP with combined prostate-specific and tetracycline-regulated expression. , 2001, Molecular therapy : the journal of the American Society of Gene Therapy.
[66] G. Barber,et al. Induction of a TRAIL mediated suicide program by interferon alpha in primary effusion lymphoma , 2001, Oncogene.
[67] A. Almasan,et al. Apo2L/TRAIL and Bcl-2-related proteins regulate type I interferon-induced apoptosis in multiple myeloma. , 2001, Blood.
[68] A. Eggermont,et al. Isolated Limb Perfusion: The European Experience , 2001 .
[69] K. Totpal,et al. Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: characterization of in vivo efficacy, pharmacokinetics, and safety. , 2001, The Journal of pharmacology and experimental therapeutics.
[70] T. Griffith,et al. Suppression of tumor growth following intralesional therapy with TRAIL recombinant adenovirus. , 2001, Molecular therapy : the journal of the American Society of Gene Therapy.
[71] P. Richardson,et al. TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications. , 2001, Blood.
[72] Z. Wang,et al. Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity , 2001, Nature Medicine.
[73] S. Nagata,et al. The membrane‐bound but not the soluble form of human Fas ligand is responsible for its inflammatory activity , 2001, European journal of immunology.
[74] P. Scheurich,et al. Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative , 2001, Oncogene.
[75] L. Altucci,et al. Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL , 2001, Nature Medicine.
[76] M. Zöller,et al. Interleukin 2-antibody and tumor necrosis factor-antibody fusion proteins induce different antitumor immune responses in vivo. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[77] I. Pollack,et al. Direct stimulation of apoptotic signaling by soluble Apo2l/tumor necrosis factor-related apoptosis-inducing ligand leads to selective killing of glioma cells. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[78] H. Koeppen,et al. Isotype-Dependent Inhibition of Tumor Growth In Vivo by Monoclonal Antibodies to Death Receptor 4 , 2001, The Journal of Immunology.
[79] S. S. Strom,et al. Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions , 2001, Nature Medicine.
[80] M. Tykocinski,et al. CTLA-4-Fas ligand functions as a trans signal converter protein in bridging antigen-presenting cells and T cells. , 2001, International immunology.
[81] E. Nabel,et al. Extracellular matrix interacts with soluble CD95L: Retention and enhancement of cytotoxicity , 2001, Nature Immunology.
[82] M. Zöller,et al. Efficacy of local versus systemic application of antibody-cytokine fusion proteins in tumor therapy. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[83] M. Smyth,et al. Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail) Contributes to Interferon γ–Dependent Natural Killer Cell Protection from Tumor Metastasis , 2001, The Journal of experimental medicine.
[84] H. Rammensee,et al. Target cell-restricted triggering of the CD95 (APO-1/Fas) death receptor with bispecific antibody fragments. , 2001, Cancer research.
[85] P. Krammer,et al. CD95 Ligand-Expressing Tumors Are Rejected in Anti-Tumor TCR Transgenic Perforin Knockout Mice , 2001, The Journal of Immunology.
[86] A. Eggermont,et al. TNF is here to stay--revisited. , 2001, Trends in immunology.
[87] R. Locksley,et al. The TNF and TNF Receptor Superfamilies Integrating Mammalian Biology , 2001, Cell.
[88] Peter Scheurich,et al. p53 upregulates cFLIP, inhibits transcription of NF-κB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells , 2001, Oncogene.
[89] R. Armitage,et al. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. , 2001, Immunity.
[90] Fulvio Magni,et al. Enhancement of tumor necrosis factor α antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13) , 2000, Nature Biotechnology.
[91] Y. Tsutsumi,et al. Human tumor necrosis factor-alpha mutant RGD-V29 (F4614) shows potent antitumor activity and reduced toxicity against human tumor xenografted nude mice. , 2000, Cancer letters.
[92] M. Rosenblum,et al. A novel recombinant fusion toxin targeting HER‐2/NEU–over‐expressing cells and containing human tumor necrosis factor , 2000, International journal of cancer.
[93] A. Almasan,et al. Apo2 ligand/TNF-related apoptosis-inducing ligand and death receptor 5 mediate the apoptotic signaling induced by ionizing radiation in leukemic cells. , 2000, Cancer research.
[94] J. Tschopp,et al. The Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptors TRAIL-R1 and TRAIL-R2 Have Distinct Cross-linking Requirements for Initiation of Apoptosis and Are Non-redundant in JNK Activation* , 2000, The Journal of Biological Chemistry.
[95] J. Norris,et al. Intracellular Fas ligand expression causes Fas-mediated apoptosis in human prostate cancer cells resistant to monoclonal antibody-induced apoptosis. , 2000, Molecular therapy : the journal of the American Society of Gene Therapy.
[96] K. Sugimachi,et al. Expression and Antitumor Effects of TRAIL in Human Cholangiocarcinoma , 2000, Hepatology.
[97] L. Owen-Schaub,et al. Fas and Fas ligand interactions in malignant disease. , 2000, International journal of oncology.
[98] E. Nabel,et al. Restricted expression of an adenoviral vector encoding Fas ligand (CD95L) enhances safety for cancer gene therapy. , 2000, Molecular therapy : the journal of the American Society of Gene Therapy.
[99] F. Zhang,et al. Adenoviral vector which delivers FasL–GFP fusion protein regulated by the tet-inducible expression system , 2000, Gene Therapy.
[100] S. Strom,et al. Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand , 2000, Nature Medicine.
[101] H. von Bernuth,et al. An interleukin-2-IgG-Fas ligand fusion protein suppresses delayed-type hypersensitivity in mice by triggering apoptosis in activated T cells as a novel strategy for immunosuppression. , 2000, Transplantation.
[102] S. Moe,et al. Opposing Effects of Transmembrane and Soluble FAS Ligand Expression on Inflammation and Tumor Cell Survival , 2000, The Journal of experimental medicine.
[103] K. Nishioka,et al. A novel murine anti-human Fas mAb which mitigates lymphadenopathy without hepatotoxicity. , 2000, International immunology.
[104] H. Macdonald,et al. Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells , 2000, European journal of immunology.
[105] A. Chinnaiyan,et al. Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[106] W. Cavenee,et al. Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo. , 2000, Cancer research.
[107] F. Batteux,et al. Expression of Fas ligand improves the effect of IL‐4 in collagen‐induced arthritis , 2000, European journal of immunology.
[108] A. Strasser,et al. Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L). , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[109] B. Gliniak,et al. Tumor necrosis factor-related apoptosis-inducing ligand's antitumor activity in vivo is enhanced by the chemotherapeutic agent CPT-11. , 1999, Cancer research.
[110] J. Dichgans,et al. Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity. , 1999, Biochemical and biophysical research communications.
[111] D. Lawrence,et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. , 1999, The Journal of clinical investigation.
[112] K. Frei,et al. Treatment of experimental glioma by administration of adenoviral vectors expressing Fas ligand. , 1999, Human gene therapy.
[113] A. Fontana,et al. Induction of antitumor immunity with Fas/APO-1 ligand (CD95L)-transfected neuroblastoma neuro-2a cells. , 1999, Journal of immunology.
[114] A. Sandler,et al. Overexpression of Fas Ligand Does Not Confer Immune Privilege to a Pancreatic β Tumor Cell Line (βTC-3) , 1999 .
[115] S. Baekkeskov,et al. A non-cleavable mutant of Fas ligand does not prevent neutrophilic destruction of islet transplants. , 1999, Transplantation.
[116] F. Dallegri,et al. Soluble Fas ligand is chemotactic for human neutrophilic polymorphonuclear leukocytes. , 1999, Journal of immunology.
[117] P. Lowenstein,et al. Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity. , 1999, The Journal of general virology.
[118] C. Rauch,et al. Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo , 1999, Nature Medicine.
[119] H. Nishimatsu,et al. Accelerated rejection of Fas ligand-expressing heart grafts. , 1999, Journal of immunology.
[120] D. Israeli,et al. p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs , 1998, The Journal of experimental medicine.
[121] L. Owen-Schaub,et al. Fas and Fas Ligand Interactions Suppress Melanoma Lung Metastasis , 1998, The Journal of experimental medicine.
[122] K. Iwabuchi,et al. Chemotactic activity of soluble Fas ligand against phagocytes. , 1998, Journal of immunology.
[123] M. Kronenberg,et al. Selective Ability of Mouse CD1 to Present Glycolipids: α-Galactosylceramide Specifically Stimulates Vα14+ NK T Lymphocytes , 1998, The Journal of Immunology.
[124] I. Weissman,et al. Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia. , 1998, Immunity.
[125] T. Giese,et al. Spontaneous Development of Plasmacytoid Tumors in Mice with Defective Fas–Fas Ligand Interactions , 1998, The Journal of experimental medicine.
[126] J. Tschopp,et al. Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity , 1998, The Journal of experimental medicine.
[127] L. Kaer,et al. Cutting Edge: Critical Role of NK1+ T Cells in IL-12-Induced Immune Responses In Vivo , 1998, The Journal of Immunology.
[128] T. Ochi,et al. Membrane Fas Ligand Kills Human Peripheral Blood T Lymphocytes, and Soluble Fas Ligand Blocks the Killing , 1997, The Journal of experimental medicine.
[129] E. Nabel,et al. Gene transfer of Fas ligand induces tumor regression in vivo. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[130] T. Inoue,et al. Amelioration of systemic autoimmune disease by the stimulation of apoptosis-promoting receptor Fas with anti-Fas mAb. , 1997, International immunology.
[131] L. Turka,et al. Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer. , 1997, The Journal of clinical investigation.
[132] D. Hanahan,et al. Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction , 1997, Nature Medicine.
[133] D. Vaux,et al. Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[134] J. Xiang,et al. Genetic engineering of a recombinant fusion possessing anti-tumor F(ab')2 and tumor necrosis factor. , 1997, Journal of biotechnology.
[135] P. Galle,et al. Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. , 1997, The Journal of clinical investigation.
[136] A. Ishii,et al. In vivo analysis of Fas antigen-mediated apoptosis: effects of agonistic anti-mouse Fas mAb on thymus, spleen and liver. , 1997, International immunology.
[137] K. Okumura,et al. Antitumor effect of locally produced CD95 ligand , 1997, Nature Medicine.
[138] A. Hayday,et al. A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice , 1996, The Journal of experimental medicine.
[139] U. Scherf,et al. Cytotoxic and antitumor activity of a recombinant tumor necrosis factor-B1(Fv) fusion protein on LeY antigen-expressing human cancer cells. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.
[140] G. Butler,et al. The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic Activation , 1996, The Journal of Biological Chemistry.
[141] C. Stoeckert,et al. Prevention of Islet Allograft Rejection with Engineered Myoblasts Expressing FasL in Mice , 1996, Science.
[142] David Wallach,et al. Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death , 1996, Cell.
[143] Matthias Mann,et al. FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex , 1996, Cell.
[144] K. Okumura,et al. CD95 ligand in graft rejection , 1996, Nature.
[145] George Kollias,et al. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor , 1995, Cell.
[146] M. Peter,et al. Cytotoxicity‐dependent APO‐1 (Fas/CD95)‐associated proteins form a death‐inducing signaling complex (DISC) with the receptor. , 1995, The EMBO journal.
[147] J. Murray,et al. An antimelanoma immunotoxin containing recombinant human tumor necrosis factor: tissue disposition, pharmacokinetic, and therapeutic studies in xenograft models , 1995, Cancer Immunology, Immunotherapy.
[148] P. Scheurich,et al. Both tumor necrosis factor receptors, TNFR60 and TNFR80, are involved in signaling endothelial tissue factor expression by juxtacrine tumor necrosis factor alpha. , 1995, Blood.
[149] J. Xiang,et al. A genetically engineered single-chain FV/TNF molecule possesses the anti-tumor immunoreactivity of FV as well as the cytotoxic activity of tumor necrosis factor. , 1995, Molecular immunology.
[150] A. Grzeschiczek,et al. Loss of Fas/Apo-1 receptor accelerates lymphomagenesis in E mu L-MYC transgenic mice but not in animals infected with MoMuLV. , 1995, Oncogene.
[151] Arul M. Chinnaiyan,et al. FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis , 1995, Cell.
[152] D. Goeddel,et al. The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation , 1995, Cell.
[153] J. Camonis,et al. A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain (*) , 1995, The Journal of Biological Chemistry.
[154] J. Healey,et al. Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[155] A. Scott,et al. Antibody targeting in metastatic colon cancer: a phase I study of monoclonal antibody F19 against a cell-surface protein of reactive tumor stromal fibroblasts. , 1994, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[156] M. Gately,et al. Interleukin-12: a cytokine with therapeutic potential in oncology and infectious diseases. , 1994, Therapeutic immunology.
[157] S. Nagata,et al. Lethal effect of the anti-Fas antibody in mice , 1993, Nature.
[158] S. Gillies,et al. Biological activity and in vivo clearance of antitumor antibody/cytokine fusion proteins. , 1993, Bioconjugate chemistry.
[159] G. Volckaert,et al. Construction and expression of antibody-tumor necrosis factor fusion proteins. , 1991, Molecular immunology.
[160] G. Volckaert,et al. Targeting of tumor necrosis factor to tumor cells: secretion by myeloma cells of a genetically engineered antibody-tumor necrosis factor hybrid molecule. , 1991, Biochimica et biophysica acta.
[161] B. Kroesen,et al. Targeted induction of apoptosis for cancer therapy , 2006 .
[162] P. Scheurich,et al. Tumor necrosis factor signaling , 2003, Cell Death and Differentiation.
[163] M. Peter,et al. The CD95(APO-1/Fas) DISC and beyond , 2003, Cell Death and Differentiation.
[164] Michael Weller,et al. Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo , 2002, Nature Medicine.
[165] C. Rüegg,et al. Suppression of tumor angiogenesis through the inhibition of integrin function and signaling in endothelial cells: which side to target? , 2002, Endothelium : journal of endothelial cell research.
[166] R. Begent,et al. In vivo tumor delivery of a recombinant single-chain Fv::Tumor necrosis factor: A fusion protein , 2002 .
[167] M. Smyth,et al. Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells , 2001, Nature Medicine.
[168] G. Pietersz,et al. In vitro and in vivo evaluation of human tumor necrosis factor-alpha (hTNFalpha) chemically conjugated to monoclonal antibody. , 1998, Journal of drug targeting.
[169] I. Krantz,et al. KILLER/DR5 is a DNA damage–inducible p53–regulated death receptor gene , 1997, Nature Genetics.
[170] J. Murray,et al. Antibody-mediated delivery of tumor necrosis factor (TNF-alpha): improvement of cytotoxicity and reduction of cellular resistance. , 1991, Cancer communications.
[171] H. Kosmehl,et al. This is an author version of the contribution published on: Questa è la versione dell’autore dell’opera: Selective targeted delivery of TNFα to tumor blood vessels , 2022 .