Chronic lung disease in HIV-infected children established on antiretroviral 1 therapy 2

Respiratory disease is a major cause of morbidity and mortality in HIV-infected children. Despite 28 antiretroviral therapy (ART), children suffer chronic symptoms. We investigated symptom 29 prevalence, lung function, and exercise capacity among older children established on ART, and an 30 age-matched HIV-uninfected group. A cross-sectional study in Zimbabwe of: 1) HIV-infected children aged 6-16 years receiving ART 33 for over six months; 2) HIV-uninfected children attending primary health clinics from the same 34 area. an older age was associated with lung function abnormality (p=0.025). No participant tested positive for M. tuberculosis . Conclusions In children, despite ART, HIV is associated with significant respiratory symptoms and functional 52 impairment. Understanding pathogenesis is key, as new treatment strategies are urgently required.

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