Automated Vision-Based High Intraocular Pressure Detection Using Frontal Eye Images

Glaucoma, the silent thief of vision, is mostly caused by the gradual increase of pressure in the eye which is known as intraocular pressure (IOP). An effective way to prevent the rise in eye pressure is by early detection. Prior computer vision-based work regarding IOP relies on fundus images of the optic nerves. This paper provides a novel vision-based framework to help in the initial IOP screening using only frontal eye images. The framework first introduces the utilization of a fully convolutional neural (FCN) network on frontal eye images for sclera and iris segmentation. Using these extracted areas, six features that include mean redness level of the sclera, red area percentage, Pupil/Iris diameter ratio, and three sclera contour features (distance, area, and angle) are computed. A database of images from the Princess Basma Hospital is used in this work, containing 400 facial images; 200 cases with normal IOP; and 200 cases with high IOP. Once the features are extracted, two classifiers (support vector machine and decision tree) are applied to obtain the status of the patients in terms of IOP (normal or high). The overall accuracy of the proposed framework is over 97.75% using the decision tree. The novelties and contributions of this work include introducing a fully convolutional network architecture for eye sclera segmentation, in addition to scientifically correlating the frontal eye view (image) with IOP by introducing new sclera contour features that have not been previously introduced in the literature from frontal eye images for IOP status determination.

[1]  J.L.R. Marrero,et al.  Intraocular pressure sensors: analysis of a passive device approach , 2003, Proceedings of the 20th IEEE Instrumentation Technology Conference (Cat. No.03CH37412).

[2]  R. Sorkhabi,et al.  Retinal Nerve Fiber Layer and Central Corneal Thickness in Patients with Exfoliation Syndrome , 2012 .

[3]  W. Eric L. Grimson,et al.  Object Segmentation of Database Images by Dual Multiscale Morphological Reconstructions and Retrieval Applications , 2012, IEEE Transactions on Image Processing.

[4]  Adam Herout,et al.  Review of Hough Transform for Line Detection , 2013 .

[5]  Trevor Darrell,et al.  Fully Convolutional Networks for Semantic Segmentation , 2017, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[6]  Miad Faezipour,et al.  Histogram analysis for automatic blood vessels detection: First step of IOP , 2015, 2015 IEEE International Conference on Electro/Information Technology (EIT).

[7]  Xiangyu Zhang,et al.  Large Kernel Matters — Improve Semantic Segmentation by Global Convolutional Network , 2017, 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[8]  Miad Faezipour,et al.  A smart intraocular pressure risk assessment framework using frontal eye image analysis , 2018, EURASIP J. Image Video Process..

[9]  Tien Yin Wong,et al.  Automatic detection of the optic cup using vessel kinking in digital retinal fundus images , 2012, 2012 9th IEEE International Symposium on Biomedical Imaging (ISBI).

[10]  Wei-Yin Loh,et al.  Classification and regression trees , 2011, WIREs Data Mining Knowl. Discov..

[11]  Andrew Thompson,et al.  The Cascading Haar Wavelet Algorithm for Computing the Walsh–Hadamard Transform , 2016, IEEE Signal Processing Letters.

[12]  Jacob Whitehill,et al.  Haar features for FACS AU recognition , 2006, 7th International Conference on Automatic Face and Gesture Recognition (FGR06).

[13]  Christopher Bowd,et al.  Learning From Data: Recognizing Glaucomatous Defect Patterns and Detecting Progression From Visual Field Measurements , 2014, IEEE Transactions on Biomedical Engineering.

[14]  Luc Van Gool,et al.  Efficient Non-Maximum Suppression , 2006, 18th International Conference on Pattern Recognition (ICPR'06).

[15]  Yu-Te Liao,et al.  Toward a Wirelessly Powered On-Lens Intraocular Pressure Monitoring System , 2016, IEEE Journal of Biomedical and Health Informatics.

[16]  M. Civan,et al.  The ins and outs of aqueous humour secretion. , 2004, Experimental eye research.

[17]  Syed Muhammad Anwar,et al.  A review analysis on early glaucoma detection using structural features , 2015, 2015 IEEE International Conference on Imaging Systems and Techniques (IST).

[18]  R. Lee,et al.  Aqueous Humor Dynamics: A Review , 2010, The open ophthalmology journal.

[19]  J. Wollensak,et al.  The resistance of the trabecular meshwork to aqueous humor outflow , 2005, Graefe's Archive for Clinical and Experimental Ophthalmology.

[20]  Radu Danescu,et al.  Real-Time Detection and Measurement of Eye Features from Color Images , 2016, Sensors.

[21]  Peter Meer,et al.  Edge Detection with Embedded Confidence , 2001, IEEE Trans. Pattern Anal. Mach. Intell..

[22]  Vladlen Koltun,et al.  Multi-Scale Context Aggregation by Dilated Convolutions , 2015, ICLR.

[23]  M. C. Leske,et al.  The epidemiology of open-angle glaucoma: a review. , 1983, American journal of epidemiology.

[24]  V. Kinsey Comparative chemistry of aqueous humor in posterior and anterior chambers of rabbit eye, its physiologic significance. , 1953, A.M.A. archives of ophthalmology.

[25]  John D. Fernandez,et al.  Facial feature detection using Haar classifiers , 2006 .

[26]  Shwetak N. Patel,et al.  A smartphone-based system for assessing intraocular pressure , 2016, 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[27]  Walker Hk,et al.  The Pupils -- Clinical Methods: The History, Physical, and Laboratory Examinations , 1990 .

[28]  Jianliang Xu,et al.  Accelerating Viola-Jones Facce Detection Algorithm on GPUs , 2012, 2012 IEEE 14th International Conference on High Performance Computing and Communication & 2012 IEEE 9th International Conference on Embedded Software and Systems.

[29]  Anushikha Singh,et al.  Glaucoma detection by segmenting the super pixels from fundus colour retinal images , 2014, 2014 International Conference on Medical Imaging, m-Health and Emerging Communication Systems (MedCom).

[30]  A. Posner Modified conversion tables for the Maklakov tonometer. , 1962, Eye, ear, nose & throat monthly.

[31]  Roberto Cipolla,et al.  SegNet: A Deep Convolutional Encoder-Decoder Architecture for Image Segmentation , 2015, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[32]  Syed Muhammad Anwar,et al.  Autonomous Glaucoma detection from fundus image using cup to disc ratio and hybrid features , 2015, 2015 IEEE International Symposium on Signal Processing and Information Technology (ISSPIT).

[33]  Jagdish Lal Raheja,et al.  Pellet Size Distribution Using Circular Hough Transform in Simulink , 2013 .

[34]  R. Moses,et al.  Schlemm's canal: the effect of intraocular pressure. , 1981, Investigative ophthalmology & visual science.

[35]  Yilin Cao,et al.  Comparison of ultrasound biomicroscopy and spectral-domain anterior segment optical coherence tomography in evaluation of anterior segment after laser peripheral iridotomy. , 2016, International journal of ophthalmology.

[36]  Miad Faezipour,et al.  High Intraocular Pressure Detection from Frontal Eye Images: A Machine Learning Based Approach , 2018, 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[37]  Iasonas Kokkinos,et al.  DeepLab: Semantic Image Segmentation with Deep Convolutional Nets, Atrous Convolution, and Fully Connected CRFs , 2016, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[38]  Tzyy-Ping Jung,et al.  Glaucoma Progression Detection Using Structural Retinal Nerve Fiber Layer Measurements and Functional Visual Field Points , 2014, IEEE Transactions on Biomedical Engineering.

[39]  Miad Faezipour,et al.  Determining the thickness of the liquid on the cornea for open and closed angle glaucoma using haar filter , 2015, 2015 Long Island Systems, Applications and Technology.

[40]  Farrokh Marvasti,et al.  Level crossing speech sampling and its sparsity promoting reconstruction using an iterative method with adaptive thresholding , 2017, IET Signal Process..

[41]  MISSING-VALUE MISSING-VALUE The Pupils , 2018, Special Needs in the Secondary School.

[42]  Frederic Fol Leymarie,et al.  Tracking Deformable Objects in the Plane Using an Active Contour Model , 1993, IEEE Trans. Pattern Anal. Mach. Intell..

[43]  Bernardo Tellini,et al.  Design of a system for continuous intraocular pressure monitoring , 2004, IEEE Transactions on Instrumentation and Measurement.