Transient tinnitus suppression induced by repetitive transcranial magnetic stimulation and transcranial direct current stimulation

Modulation of activity in the left temporoparietal area (LTA) by 10 Hz repetitive transcranial magnetic stimulation (rTMS) results in a transient reduction of tinnitus. We aimed to replicate these results and test whether transcranial direct current stimulation (tDCS) of LTA could yield similar effect. Patients with tinnitus underwent six different types of stimulation in a random order: 10‐Hz rTMS of LTA, 10‐Hz rTMS of mesial parietal cortex, sham rTMS, anodal tDCS of LTA, cathodal tDCS of LTA and sham tDCS. A non‐parametric analysis of variance showed a significant main effect of type of stimulation (P = 0.002) and post hoc tests showed that 10‐Hz rTMS and anodal tDCS of LTA resulted in a significant reduction of tinnitus. These effects were short lasting. These results replicate the findings of the previous study and, in addition, show preliminary evidence that anodal tDCS of LTA induces a similar transient tinnitus reduction as high‐frequency rTMS.

[1]  HighWire Press Philosophical Transactions of the Royal Society of London , 1781, The London Medical Journal.

[2]  D. Purpura,et al.  INTRACELLULAR ACTIVITIES AND EVOKED POTENTIAL CHANGES DURING POLARIZATION OF MOTOR CORTEX. , 1965, Journal of neurophysiology.

[3]  M Schwaiger,et al.  Focal metabolic activation in the predominant left auditory cortex in patients suffering from tinnitus: a PET study with [18F]deoxyglucose. , 1996, ORL; journal for oto-rhino-laryngology and its related specialties.

[4]  R. Salvi,et al.  Evidence for limbic system links and neural plasticity , 1998 .

[5]  T. Elbert,et al.  Reorganization of auditory cortex in tinnitus. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Albert Gjedde,et al.  Positron emission tomography of cortical centers of tinnitus , 1999, Hearing Research.

[7]  A. Vighetto,et al.  A selective imaging of tinnitus. , 1999, Neuroreport.

[8]  Á. Pascual-Leone,et al.  Transcranial magnetic stimulation: studying the brain-behaviour relationship by induction of 'virtual lesions'. , 1999, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[9]  M. Nitsche,et al.  Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation , 2000, The Journal of physiology.

[10]  M. Nitsche,et al.  Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans , 2001, Neurology.

[11]  M. Nitsche,et al.  External modulation of visual perception in humans , 2001, Neuroreport.

[12]  Ronald Klein,et al.  Prevalence and 5-year incidence of tinnitus among older adults: the epidemiology of hearing loss study. , 2002, Journal of the American Academy of Audiology.

[13]  Christian Gerloff,et al.  Transient suppression of tinnitus by transcranial magnetic stimulation , 2003, Annals of neurology.

[14]  J. Rothwell,et al.  Level of action of cathodal DC polarisation induced inhibition of the human motor cortex , 2003, Clinical Neurophysiology.

[15]  B. Langguth,et al.  Neuronavigated repetitive transcranial magnetic stimulation in patients with tinnitus: a short case series , 2003, Biological Psychiatry.

[16]  B. Langguth,et al.  Neuronavigated rTMS in a patient with chronic tinnitus. Effects of 4 weeks treatment , 2003, Neuroreport.

[17]  J. Eggermont,et al.  The neuroscience of tinnitus , 2004, Trends in Neurosciences.

[18]  K. Hoffmann,et al.  Direct Current Stimulation over V5 Enhances Visuomotor Coordination by Improving Motion Perception in Humans , 2004, Journal of Cognitive Neuroscience.

[19]  B. Langguth,et al.  [Low frequency repetitive transcranial magnetic stimulation (rTMS) for the treatment of chronic tinnitus--are there long-term effects?]. , 2004, Psychiatrische Praxis.

[20]  Paul Mitchell,et al.  Factors predicting severity of tinnitus: a population-based assessment. , 2004, Journal of the American Academy of Audiology.

[21]  J. Rothwell,et al.  Preconditioning of Low-Frequency Repetitive Transcranial Magnetic Stimulation with Transcranial Direct Current Stimulation: Evidence for Homeostatic Plasticity in the Human Motor Cortex , 2004, The Journal of Neuroscience.

[22]  Gyula Kovács,et al.  Direct current stimulation over MT+/V5 modulates motion aftereffect in humans , 2004, Neuroreport.

[23]  Stefan Sunaert,et al.  Magnetic and electrical stimulation of the auditory cortex for intractable tinnitus. Case report. , 2004, Journal of neurosurgery.

[24]  B. Langguth,et al.  Behandlung von chronischem Tinnitus mit niedrigfrequenter repetitiver transkranieller Magnetstimulation (rTMS) - gibt es Langzeiteffekte? , 2004 .

[25]  Stefan Sunaert,et al.  Transcranial Magnetic Stimulation for Tinnitus: Influence of Tinnitus Duration on Stimulation Parameter Choice and Maximal Tinnitus Suppression , 2005, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[26]  Richard S. J. Frackowiak,et al.  How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain? , 2005, The European journal of neuroscience.

[27]  D. Liebetanz,et al.  Modulating parameters of excitability during and after transcranial direct current stimulation of the human motor cortex , 2005, Clinical Neurophysiology.