Long‐term results of a randomized trial comparing preoperative short‐course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer

Neoadjuvant chemoradiotherapy does not alter anal sphincter preservation or postoperative complications compared with short‐course radiotherapy alone in patients with clinical stage T3 or T4 resectable rectal cancer. The aim of this study was to compare survival, local control and late toxicity in the two treatment groups.

[1]  E. Chmielik,et al.  Distal intramural spread of rectal cancer after preoperative radiotherapy: the results of a multicenter randomized clinical study. , 2006, International journal of radiation oncology, biology, physics.

[2]  L. Påhlman,et al.  Adverse effects of preoperative radiation therapy for rectal cancer: long-term follow-up of the Swedish Rectal Cancer Trial. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[3]  T. Conroy,et al.  Preoperative Chemoradiotherapy (CT-RT) Improves Local Control in T3-4 Rectal Cancers: Results of the FFCD 9203 Randomized Trial , 2005 .

[4]  L. Påhlman,et al.  The multidisciplinary rectal cancer treatment: main convergences, controversial aspects and investigational areas which support the need for an European Consensus. , 2005, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[5]  Laurence Collette,et al.  Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results--EORTC 22921. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[6]  P. Vávra,et al.  Distal intramural spread of rectal cancer , 2005, European Surgery.

[7]  K. Bujko,et al.  Postoperative complications in patients irradiated pre‐operatively for rectal cancer: report of a randomised trial comparing short‐term radiotherapy vs chemoradiation , 2005, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[8]  L. Collette,et al.  Preoperative radiation (Preop RT) in rectal cancer: Effect and timing of additional chemotherapy (CT) 5-year results of the EORTC 22921 trial , 2005 .

[9]  Rainer Fietkau,et al.  Preoperative versus postoperative chemoradiotherapy for rectal cancer. , 2004, The New England journal of medicine.

[10]  J. Kładny,et al.  Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy. , 2004, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[11]  P. Adeleine,et al.  Improved sphincter preservation in low rectal cancer with high-dose preoperative radiotherapy: the lyon R96-02 randomized trial. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[12]  S. Tretli,et al.  Oncological Outcomes After Total Mesorectal Excision for Cure for Cancer of the Lower Rectum: Anterior vs. Abdominoperineal Resection , 2004, Diseases of the colon and rectum.

[13]  C. V. D. van de Velde,et al.  Acute side effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: report of a multicenter randomized trial. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[14]  Rieken,et al.  [Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer]. , 2001, Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al].

[15]  P. Adeleine,et al.  Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter-sparing surgery for rectal cancer: the Lyon R90-01 randomized trial. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[16]  L. Holmberg,et al.  Short-term preoperative radiotherapy results in down-staging of rectal cancer: a study of 1316 patients. , 1997, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[17]  B. Minsky.  Adjuvant therapy for rectal cancer--a good first step. , 1997, The New England journal of medicine.

[18]  L Påhlman,et al.  Improved survival with preoperative radiotherapy in resectable rectal cancer. , 1997, The New England journal of medicine.

[19]  L. Påhlman,et al.  Radiotherapy in addition to radical surgery in rectal cancer: evidence for a dose-response effect favoring preoperative treatment. , 1997, International journal of radiation oncology, biology, physics.

[20]  B. Cedermark,et al.  Randomized study on preoperative radiotherapy in rectal carcinoma , 1996, Annals of Surgical Oncology.

[21]  H. Johansson,et al.  The Stockholm I trial of preoperative short term radiotherapy in operable rectal carcinoma , 1995, Cancer.

[22]  T. Pajak,et al.  Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) , 1995, International journal of radiation oncology, biology, physics.

[23]  L. Påhlman,et al.  Initial report from a Swedish multicentre study examining the role of preoperative irradiation in the treatment of patients with resectable rectal carcinoma , 1993, The British journal of surgery.

[24]  L. Påhlman,et al.  Preoperative or postoperative irradiation in adenocarcinoma of the rectum: Final treatment results of a randomized trial and an evaluation of late secondary effects , 1993, Diseases of the colon and rectum.

[25]  L. Påhlman,et al.  Pre‐ versus postoperative radiotherapy in rectal carcinoma: an interim report from a randomized multicentre trial , 1985, The British journal of surgery.

[26]  H. Gallager,et al.  INTACT TUMOR CELLS IN IRRADIATED TISSUE. , 1964, Archives of pathology.

[27]  M. Choti,et al.  Rectal cancer. , 2012, Journal of the National Comprehensive Cancer Network : JNCCN.

[28]  M. Piérart,et al.  Preoperative chemoradiotherapy versus preoperative radiotherapy in rectal cancer patients: assessment of acute toxicity and treatment compliance. Report of the 22921 randomised trial conducted by the EORTC Radiotherapy Group. , 2004, European journal of cancer.

[29]  LENT SOMA tables. , 1995, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.