Characterization of 5-HT receptors in the human saphenous vein, implications for patency of bypass grafts

Endogenous 5-hydroxytryptamine (5-HT) could be implicated in producing vasospasm and/or thrombosis in saphenous vein grafts and native epicardial coronary arteries after aortocoronary bypass grafting. The contractile effect of 5-HT, and other 5-HT receptor agonists were measured on the human saphenous vein in vitro