Design, Simulation and Performance Research of New Biomaterial Mg30Zn30Sn30Sr5Bi5

This study focused on the design and the preparation method of a new biomaterial, Mg30Zn30Sn30Sr5Bi5 (at%) alloy, and its simulation and property analyses. Based on the comprehensive consideration of the preparation of high-entropy alloys, the selection of biomaterial elements, and the existing research results of common Mg-based materials, the atomic percentage of various elements, that is, Mg:Zn:Sn:Sr:Bi = 30:30:30:5:5, was determined. Using the theoretical methods of thermodynamic performance analysis and solidification performance analysis, the proposed composition was simulated and analyzed. The analysis results showed that the mechanical properties of the new material can meet the design requirements, and it can be prepared in physical form. XRD, SEM, PSD, compression tests, and other experimental tests were conducted on the material, and the alloy composition and distribution law showed various characteristics, which conformed to the “chaotic” characteristics of high-entropy alloys. The elastic modulus of the material was 17.98 GPa, which is within the 0–20 GPa elastic modulus range of human bone. This means that it can avoid the occurrence of stress shielding problems more effectively during the material implantation process.

[1]  D. Toghraie,et al.  Coating the magnesium implants with reinforced nanocomposite nanoparticles for use in orthopedic applications , 2021, Colloids and Surfaces A: Physicochemical and Engineering Aspects.

[2]  Shijie Zhu,et al.  Effects of Sr addition on microstructure, mechanical and corrosion properties of biodegradable Mg–Zn–Ca alloy , 2020 .

[3]  L. Sheng,et al.  Effects of annealing treatment on microstructure and tensile behavior of the Mg-Zn-Y-Nd alloy , 2020, Journal of Magnesium and Alloys.

[4]  G. Haiat,et al.  Stress shielding at the bone‐implant interface: Influence of surface roughness and of the bone‐implant contact ratio , 2020, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[5]  N. Mukhopadhyay,et al.  Phase Evolution and Thermal Stability of Low-Density MgAlSiCrFe High-Entropy Alloy Processed Through Mechanical Alloying , 2020, Transactions of the Indian Institute of Metals.

[6]  Ajit Kumar,et al.  Development of Mg based biomaterial with improved mechanical and degradation properties using powder metallurgy , 2020 .

[7]  Yufeng Zheng,et al.  In vitro and in vivo degradation behavior of Mg–2Sr–Ca and Mg–2Sr–Zn alloys , 2020, Bioactive materials.

[8]  N. Mukhopadhyay,et al.  Phase Evolution and Thermal Stability of Mechanically Alloyed AlCrFeCoNiZn High-Entropy Alloy , 2020, Transactions of the Indian Institute of Metals.

[9]  Y. Aoki,et al.  Superconducting properties of high-entropy-alloy tellurides M-Te (M: Ag, In, Cd, Sn, Sb, Pb, Bi) with a NaCl-type structure , 2020, Applied Physics Express.

[10]  Yufeng Zheng,et al.  Fundamental Theory of Biodegradable Metals—Definition, Criteria, and Design , 2019, Advanced Functional Materials.

[11]  W. Curtin,et al.  First-principles-based prediction of yield strength in the RhIrPdPtNiCu high-entropy alloy , 2019, npj Computational Materials.

[12]  F. Witte,et al.  Biodegradable Metals , 2018, Biomaterials Science.

[13]  M. Gupta,et al.  Microstructural Evolution in MgAlLiZnCaY and MgAlLiZnCaCu Multicomponent High Entropy Alloys , 2018, Materials Science Forum.

[14]  Jinshan Zhang,et al.  Corrosion Behaviors of Long‐Period Stacking Ordered Structure in Mg Alloys Used in Biomaterials: A Review , 2018 .

[15]  Changchun Zhou,et al.  Bio-Functional Design, Application and Trends in Metallic Biomaterials , 2017, International journal of molecular sciences.

[16]  Yufeng Zheng,et al.  Improved cytocompatibility of Mg-1Ca alloy modified by Zn ion implantation and deposition , 2017 .

[17]  Henning Windhagen,et al.  Examination of a biodegradable magnesium screw for the reconstruction of the anterior cruciate ligament: A pilot in vivo study in rabbits. , 2016, Materials science & engineering. C, Materials for biological applications.

[18]  W. Crichton,et al.  Equilibrium high entropy phases in X-NbTaTiZr (X = Al,V,Cr and Sn) multiprincipal component alloys , 2016 .

[19]  Reza Vatankhah Barenji,et al.  Introducing natural hydroxyapatite-diopside (NHA-Di) nano-bioceramic coating , 2015 .

[20]  Yao Zhou,et al.  Microstructure and Mechanical Properties of AZ81 Magnesium Alloy , 2015 .

[21]  P. Rivera-Díaz-del-Castillo,et al.  Modelling solid solution hardening in high entropy alloys , 2015 .

[22]  Yujuan Wu,et al.  Uniform corrosion behavior of GZ51K alloy with long period stacking ordered structure for biomedical application , 2014 .

[23]  V. Neubert,et al.  In vivo study of a biodegradable orthopedic screw (MgYREZr-alloy) in a rabbit model for up to 12 months , 2014, Journal of biomaterials applications.

[24]  Ke Yang,et al.  Biodegradable Materials for Bone Repairs: A Review , 2013 .

[25]  M. Alizadeh,et al.  Physicochemical Properties and Cellular Responses of Strontium-Doped Gypsum Biomaterials , 2012, Bioinorganic chemistry and applications.

[26]  Y. Zheng,et al.  Corrosion fatigue behaviors of two biomedical Mg alloys - AZ91D and WE43 - In simulated body fluid. , 2010, Acta biomaterialia.

[27]  P. Liaw,et al.  Refractory high-entropy alloys , 2010 .

[28]  Yufeng Zheng,et al.  Corrosion of, and cellular responses to Mg-Zn-Ca bulk metallic glasses. , 2010, Biomaterials.

[29]  P. Uggowitzer,et al.  MgZnCa glasses without clinically observable hydrogen evolution for biodegradable implants. , 2009, Nature materials.

[30]  H. Frost,et al.  A 2003 update of bone physiology and Wolff's Law for clinicians. , 2009, The Angle orthodontist.

[31]  Indran Amirthanayagam,et al.  Lead , 2006, Pediatric Environmental Health.

[32]  J. Nellesen,et al.  Cartilage repair on magnesium scaffolds used as a subchondral bone replacement , 2006 .

[33]  B. Cantor,et al.  Microstructural development in equiatomic multicomponent alloys , 2004 .

[34]  T. Shun,et al.  Nanostructured High‐Entropy Alloys with Multiple Principal Elements: Novel Alloy Design Concepts and Outcomes , 2004 .

[35]  J. R. Thompson,et al.  Tin , 1894, The American journal of dental science.

[36]  W. J. Kim,et al.  Development of biodegradable Mg-Ca alloy sheets with enhanced strength and corrosion properties through the refinement and uniform dispersion of the Mg₂Ca phase by high-ratio differential speed rolling. , 2015, Acta biomaterialia.

[37]  Yan Li,et al.  Effects of tensile and compressive deformation on corrosion behaviour of a Mg–Zn alloy , 2015 .

[38]  G. Thouas,et al.  Metallic implant biomaterials , 2015 .

[39]  Ke Yang,et al.  In vitro degradation and biocompatibility of a strontium-containing micro-arc oxidation coating on the biodegradable ZK60 magnesium alloy , 2014 .

[40]  Ebrahim Karamian,et al.  Original Research An in vitro evaluation of novel NHA/zircon plasma coating on 316L stainless steel dental implant , 2014 .

[41]  D. Wenjiang.  Research Progress of Mg-Based Alloys as Degradable Biomedical Materials , 2011 .

[42]  C. Wei.  Effect of Sr addition on the microstructure and the properties of AZ91 magnesium alloy , 2008 .

[43]  Sun Wei.  Current Research Progress of β-type Ti-Nb-Ta-Zr Alloys for Biomedical Applications , 2008 .