Rapid prototyping technology and its application in bone tissue engineering

Bone defects arising from a variety of reasons cannot be treated effectively without bone tissue reconstruction. Autografts and allografts have been used in clinical application for some time, but they have disadvantages. With the inherent drawback in the precision and reproducibility of conventional scaffold fabrication techniques, the results of bone surgery may not be ideal. This is despite the introduction of bone tissue engineering which provides a powerful approach for bone repair. Rapid prototyping technologies have emerged as an alternative and have been widely used in bone tissue engineering, enhancing bone tissue regeneration in terms of mechanical strength, pore geometry, and bioactive factors, and overcoming some of the disadvantages of conventional technologies. This review focuses on the basic principles and characteristics of various fabrication technologies, such as stereolithography, selective laser sintering, and fused deposition modeling, and reviews the application of rapid prototyping techniques to scaffolds for bone tissue engineering. In the near future, the use of scaffolds for bone tissue engineering prepared by rapid prototyping technology might be an effective therapeutic strategy for bone defects.中文概要题目快速成型技术及其在骨组织工程中的应用概要骨缺损的修复是临床工作中亟待解决的难题,寻 求完善的骨移植替代物一直是各国学者的研究 焦点所在。近年来快速成型技术在骨组织工程领 域内的应用逐渐扩大,个体化定制的优势为骨缺 损修复提供了新思路。本文对快速成型技术在骨 组织工程中的研究进展进行综述,概述了不同快 速成型技术的原理和特点,总结其在骨组织工程 中的应用现状和发展趋势。