Analysis of different risk factors of hospitalized COVID-19 patients from North-Eastern Bangladesh

Background: In Bangladesh, fighting with the delta sub variety of SARS-CoV-2 was most difficult than its previous and following waves. The aim of this study is to shed light upon different risk factors of COVID-19 and their influences across age-groups inpatients in North-Eastern Districts. Methods: In this case control study, we included 75 positive and 24 negative patients admitted to Jalalabad Ragib Rabeya Medical College and Hospital, Sylhet, Bangladesh from 1st August to 30th September 2021. Different demographic, clinical and radiographic data were collected, analyzed, and compared between/among patients to assess diseases severity. Results: On average patients with COVID-19 were more likely to display remarkably 4, 1.3, and 1.5 times higher serum D-dimer, C-reactive protein, and ferritin level compared to non-COVID-19 people. Higher number of elderly inpatients from the age of 40; specially 60 years and older accounted for the abnormal rise of the aforesaid biochemical risk factors. This age range was also concerning for intensive care unit admission and multiple biomarker elevation. Nevertheless, the percentage of hospitalized COVID-19 patients with hypertension and diabetes is calculated 45% and 30.3%. Alarmingly, 96% of our patients showed COVID-19 assisted lung abnormalities diagnosed by computerized tomography scan and hither the order for degree of damage was bilateral consolidation>ground-glass opacity>pulmonary lesion>chronic obstructive pulmonary disease>cardiomegaly. Conclusions: Age is the principle demographic risk factor of COVID-19, and it has positive correlation with different hospital outcomes, biochemical risk factors, abnormal radiographic manifestations and comorbidities.